Smad2 and p38 signaling pathways act in concert to determine xy primordial germ cell fate in mice

Development (Cambridge)

Volumn 142, Issue 3, 2015, Pages 575-586

  Wu, Quan ^a,b   Fukuda, Kurumi ^a,b   Weinstein, Michael ^c   Graff, Jonathan M ^d   Saga, Yumiko ^a,b  

^a GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Meiosis; Nanos2; P38 signaling; Sex determination; SMAD2 signaling; Smad2 3 conditional knockout mice

Indexed keywords

ACTIVIN; FIBROBLAST GROWTH FACTOR 9; MITOGEN ACTIVATED PROTEIN KINASE P38; NODAL SIGNALING PROTEIN; RETINOIC ACID; SMAD2 PROTEIN; INHIBIN; INHIBIN BETA A SUBUNIT; NODAL PROTEIN, MOUSE; PRIMER DNA; PROTEIN NODAL; SMAD2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FATE; CONTROLLED STUDY; GENE; GENE DELETION; GENE EXPRESSION; GONAD DEVELOPMENT; MALE; MEIOSIS; MOUSE; NODAL GENE; NONHUMAN; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENTIATION; SIGNAL TRANSDUCTION; SMAD2 GENE; SMAD3 GENE; SOMATIC CELL; SRY GENE; ANALYSIS OF VARIANCE; ANIMAL; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; IMAGE PROCESSING; IN SITU HYBRIDIZATION; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOZOON; WESTERN BLOTTING;

MUS;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; DNA PRIMERS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION; INHIBIN-BETA SUBUNITS; MALE; MICE; MICE, INBRED ICR; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; NODAL PROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SPERMATOZOA; TRETINOIN;

EID: 84921502817     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.119446     Document Type: Article

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