Synthesis of a high-purity chemical library reveals a potent inducer of oxidative stress

ChemBioChem

Volumn 11, Issue 9, 2010, Pages 1224-1227

  Cui, Jiayue ^a   Matsumoto, Kenji ^a   Wang, Cindy Y ^b   Peter, Marcus E ^b   Kozmin, Sergey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Apoptosis; Caspases; Chemical libraries; Cytotoxicity; Reactive oxygen species

Indexed keywords

DNA FRAGMENT; GLYCYCLAMIDE; REACTIVE OXYGEN METABOLITE; TRIAZATRICYCLAMIDE; UNCLASSIFIED DRUG; CASPASE 3; CASPASE 7; MOLECULAR LIBRARY; SULFONYLUREA DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; SYNTHESIS; CHEMISTRY; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

CASPASE 3; CASPASE 7; CELL LINE, TUMOR; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONYLUREA COMPOUNDS;

EID: 77953432730     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000193     Document Type: Article

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