메뉴 건너뛰기




Volumn 2, Issue , 2013, Pages

Progress towards a hepatitis C virus vaccine

Author keywords

HCV; hepatitis; infection; prophylactic; therapeutic; vaccine

Indexed keywords

HEPATITIS C VACCINE; NEUTRALIZING ANTIBODY;

EID: 84921484801     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1038/emi.2013.77     Document Type: Review
Times cited : (43)

References (76)
  • 1
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244: 359-362.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 2
    • 79751513059 scopus 로고    scopus 로고
    • Hepatitis in 2010: The dawn of a new era in HCV therapy
    • Ciesek S, Manns MP. Hepatitis in 2010: the dawn of a new era in HCV therapy. Nat Rev Gastroenterol Hepatol 2011; 8: 69-71.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 69-71
    • Ciesek, S.1    Manns, M.P.2
  • 3
    • 84867404172 scopus 로고    scopus 로고
    • Direct-acting and host-targeting HCV inhibitors: Current and future directions
    • Chatel-Chaix L, Germain MA, Gotte M, Lamarre D. Direct-acting and host-targeting HCV inhibitors: current and future directions. Curr Opin Virol 2012; 2: 588-598.
    • (2012) Curr Opin Virol , vol.2 , pp. 588-598
    • Chatel-Chaix, L.1    Germain, M.A.2    Gotte, M.3    Lamarre, D.4
  • 4
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009; 41: 1105-1109.
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 5
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 6
    • 82755182674 scopus 로고    scopus 로고
    • Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
    • Susser S, Vermehren J, Forestier N et al. Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir. J Clin Virol 2011; 52: 321-327.
    • (2011) J Clin Virol , vol.52 , pp. 321-327
    • Susser, S.1    Vermehren, J.2    Forestier, N.3
  • 7
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • Sarrazin C, Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 2010; 138: 447-462.
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 9
    • 25844523297 scopus 로고    scopus 로고
    • Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
    • Simmonds P, Bukh J, Combet C et al. Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 2005; 42: 962-973.
    • (2005) Hepatology , vol.42 , pp. 962-973
    • Simmonds, P.1    Bukh, J.2    Combet, C.3
  • 10
    • 45749124737 scopus 로고    scopus 로고
    • Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems
    • Gottwein JM, Bukh J. Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems. Adv Virus Res 2008; 71: 51-133.
    • (2008) Adv Virus Res , vol.71 , pp. 51-133
    • Gottwein, J.M.1    Bukh, J.2
  • 11
    • 33747797031 scopus 로고    scopus 로고
    • Treating viral hepatitis C: Efficacy, side effects, and complications
    • Manns MP, Wedemeyer H, Cornberg M. Treating viral hepatitis C: efficacy, side effects, and complications. Gut 2006; 55: 1350-1359.
    • (2006) Gut , vol.55 , pp. 1350-1359
    • Manns, M.P.1    Wedemeyer, H.2    Cornberg, M.3
  • 12
    • 4444365401 scopus 로고    scopus 로고
    • The natural history of hepatitis C
    • Afdhal NH. The natural history of hepatitis C. Semin Liver Dis 2004; 24 (Suppl 2): 3-8.
    • (2004) Semin Liver Dis , vol.24 , pp. 3-8
    • Afdhal, N.H.1
  • 13
    • 78049393044 scopus 로고    scopus 로고
    • Adaptive immunity to the hepatitis C virus
    • Walker CM. Adaptive immunity to the hepatitis C virus. Adv Virus Res 2010; 78: 43-86.
    • (2010) Adv Virus Res , vol.78 , pp. 43-86
    • Walker, C.M.1
  • 14
    • 0142178211 scopus 로고    scopus 로고
    • HCV persistence and immune evasion in the absence of memory T cell help
    • Grakoui A, Shoukry NH, Woollard DJ et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 2003; 302: 659-662.
    • (2003) Science , vol.302 , pp. 659-662
    • Grakoui, A.1    Shoukry, N.H.2    Woollard, D.J.3
  • 15
    • 0038543543 scopus 로고    scopus 로고
    • Memory CD81 T cells are required for protection from persistent hepatitis C virus infection
    • Shoukry NH, Grakoui A, Houghton M et al. Memory CD81 T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 2003; 197: 1645-1655.
    • (2003) J Exp Med , vol.197 , pp. 1645-1655
    • Shoukry, N.H.1    Grakoui, A.2    Houghton, M.3
  • 16
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001; 194: 1395-1406.
    • (2001) J Exp Med , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 17
    • 0037180506 scopus 로고    scopus 로고
    • Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
    • Thimme R, Bukh J, Spangenberg HC et al. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci USA 2002; 99: 15661-15668.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15661-15668
    • Thimme, R.1    Bukh, J.2    Spangenberg, H.C.3
  • 18
    • 4444354594 scopus 로고    scopus 로고
    • High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection
    • Lauer GM, Barnes E, Lucas M et al. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004; 127: 924-936.
    • (2004) Gastroenterology , vol.127 , pp. 924-936
    • Lauer, G.M.1    Barnes, E.2    Lucas, M.3
  • 19
    • 3042841149 scopus 로고    scopus 로고
    • Neutralizing antibody response during acute and chronic hepatitis C virus infection
    • Logvinoff C, Major ME, Oldach D et al. Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proc Natl Acad Sci USA 2004; 101: 10149-10154.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10149-10154
    • Logvinoff, C.1    Major, M.E.2    Oldach, D.3
  • 20
    • 0034646996 scopus 로고    scopus 로고
    • The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
    • Farci P, Shimoda A, Coiana A et al. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 2000; 288: 339-344.
    • (2000) Science , vol.288 , pp. 339-344
    • Farci, P.1    Shimoda, A.2    Coiana, A.3
  • 21
    • 12644289313 scopus 로고    scopus 로고
    • Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein
    • Farci P, Shimoda A, Wong D et al. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci USA 1996; 93: 15394-15399.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15394-15399
    • Farci, P.1    Shimoda, A.2    Wong, D.3
  • 22
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • von Hahn T, Yoon JC, Alter H et al. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 2007; 132: 667-678.
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • Von Hahn, T.1    Yoon, J.C.2    Alter, H.3
  • 23
    • 66149119738 scopus 로고    scopus 로고
    • Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus
    • Dowd KA, Netski DM, Wang XH, Cox AL, Ray SC. Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus. Gastroenterology 2009; 136: 2377-2386.
    • (2009) Gastroenterology , vol.136 , pp. 2377-2386
    • Dowd, K.A.1    Netski, D.M.2    Wang, X.H.3    Cox, A.L.4    Ray, S.C.5
  • 24
    • 0027403907 scopus 로고
    • Equilibrium centrifugation studies of hepatitis C virus: Evidence for circulating immune complexes
    • HijikataM, Shimizu YK, Kato H et al. Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexes. J Virol 1993; 67: 1953-1958.
    • (1993) J Virol , vol.67 , pp. 1953-1958
    • Hijikatam Shimizu, Y.K.1    Kato, H.2
  • 25
    • 0037416146 scopus 로고    scopus 로고
    • Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
    • Bartosch B, Dubuisson J, Cosset FL. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J Exp Med 2003; 197: 633-642.
    • (2003) J Exp Med , vol.197 , pp. 633-642
    • Bartosch, B.1    Dubuisson, J.2    Cosset, F.L.3
  • 26
    • 0038471344 scopus 로고    scopus 로고
    • Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    • Hsu M, Zhang J, Flint M et al. Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci USA 2003; 100: 7271-7276.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7271-7276
    • Hsu, M.1    Zhang, J.2    Flint, M.3
  • 27
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T, Pietschmann T, Kato T et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005; 11: 791-796.
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3
  • 28
    • 23044437222 scopus 로고    scopus 로고
    • Complete replication of hepatitis C virus in cell culture
    • Lindenbach BD, Evans MJ, Syder AJ et al. Complete replication of hepatitis C virus in cell culture. Science 2005; 309: 623-626.
    • (2005) Science , vol.309 , pp. 623-626
    • Lindenbach, B.D.1    Evans, M.J.2    Syder, A.J.3
  • 29
    • 72249087933 scopus 로고    scopus 로고
    • Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection
    • Osburn WO, Fisher BE, DowdKA et al. Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection. Gastroenterology 2010; 138: 315-324.
    • (2010) Gastroenterology , vol.138 , pp. 315-324
    • Osburn, W.O.1    Fisher, B.E.2    Dowd, K.A.3
  • 30
    • 34347230939 scopus 로고    scopus 로고
    • Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    • Pestka JM, Zeisel MB, Blaser E et al. Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci USA 2007; 104: 6025-6030.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6025-6030
    • Pestka, J.M.1    Zeisel, M.B.2    Blaser, E.3
  • 31
    • 77956168246 scopus 로고    scopus 로고
    • Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins
    • DahariH, Feinstone SM, Major ME. Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins. Gastroenterology 2010; 139: 965-974.
    • (2010) Gastroenterology , vol.139 , pp. 965-974
    • Daharih Feinstone, S.M.1    Major, M.E.2
  • 32
    • 84863774072 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
    • Burton DR, Poignard P, Stanfield RL, Wilson IA. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science 2012; 337: 183-186.
    • (2012) Science , vol.337 , pp. 183-186
    • Burton, D.R.1    Poignard, P.2    Stanfield, R.L.3    Wilson, I.A.4
  • 33
    • 84859393693 scopus 로고    scopus 로고
    • Immune-correlates analysis of an HIV-1 vaccine efficacy trial
    • Haynes BF, Gilbert PB, McElrath MJ et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med 2012; 366: 1275-1286.
    • (2012) N Engl J Med , vol.366 , pp. 1275-1286
    • Haynes, B.F.1    Gilbert, P.B.2    McElrath, M.J.3
  • 34
    • 73349094086 scopus 로고    scopus 로고
    • Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    • Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 2009; 361: 2209-2220.
    • (2009) N Engl J Med , vol.361 , pp. 2209-2220
    • Rerks-Ngarm, S.1    Pitisuttithum, P.2    Nitayaphan, S.3
  • 35
    • 84863183220 scopus 로고    scopus 로고
    • Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion
    • Raghuraman S, Park H, Osburn WO, Winkelstein E, Edlin BR, Rehermann B. Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion. J Infect Dis 2012; 205: 763-771.
    • (2012) J Infect Dis , vol.205 , pp. 763-771
    • Raghuraman, S.1    Park, H.2    Osburn, W.O.3    Winkelstein, E.4    Edlin, B.R.5    Rehermann, B.6
  • 36
    • 0033840190 scopus 로고    scopus 로고
    • Antibodies against hepatitis C virus-like particles and viral clearance in acute and chronic hepatitis C
    • Baumert TF, Wellnitz S, Aono S et al. Antibodies against hepatitis C virus-like particles and viral clearance in acute and chronic hepatitis C. Hepatology 2000; 32: 610-617.
    • (2000) Hepatology , vol.32 , pp. 610-617
    • Baumert, T.F.1    Wellnitz, S.2    Aono, S.3
  • 37
    • 78650536657 scopus 로고    scopus 로고
    • Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses
    • Houghton M. Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses. Immunol Rev 2011; 239: 99-108.
    • (2011) Immunol Rev , vol.239 , pp. 99-108
    • Houghton, M.1
  • 38
    • 77955661037 scopus 로고    scopus 로고
    • Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults
    • Frey SE, Houghton M, Coates S et al. Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. Vaccine 2010; 28: 6367-6373.
    • (2010) Vaccine , vol.28 , pp. 6367-6373
    • Frey, S.E.1    Houghton, M.2    Coates, S.3
  • 39
    • 0026767691 scopus 로고
    • Lack of protective immunity against reinfection with hepatitis C virus
    • Farci P, Alter HJ, Govindarajan S et al. Lack of protective immunity against reinfection with hepatitis C virus. Science 1992; 258: 135-140.
    • (1992) Science , vol.258 , pp. 135-140
    • Farci, P.1    Alter, H.J.2    Govindarajan, S.3
  • 40
    • 27744438976 scopus 로고    scopus 로고
    • Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model
    • Prince AM, Brotman B, Lee DH et al. Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model. J Infect Dis 2005; 192: 1701-1709.
    • (2005) J Infect Dis , vol.192 , pp. 1701-1709
    • Prince, A.M.1    Brotman, B.2    Lee, D.H.3
  • 41
    • 0030587469 scopus 로고    scopus 로고
    • A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures
    • Shimizu YK, Igarashi H, Kiyohara T et al. A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures. Virology 1996; 223: 409-412.
    • (1996) Virology , vol.223 , pp. 409-412
    • Shimizu, Y.K.1    Igarashi, H.2    Kiyohara, T.3
  • 42
    • 37849010852 scopus 로고    scopus 로고
    • Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus
    • Meunier JC, Russell RS, Goossens V et al. Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus. J Virol 2008; 82: 966-973.
    • (2008) J Virol , vol.82 , pp. 966-973
    • Meunier, J.C.1    Russell, R.S.2    Goossens, V.3
  • 43
    • 80052186961 scopus 로고    scopus 로고
    • Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies
    • Verstrepen BE, Depla E, Rollier CS et al. Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies. J Infect Dis 2011; 204: 837-844.
    • (2011) J Infect Dis , vol.204 , pp. 837-844
    • Verstrepen, B.E.1    Depla, E.2    Rollier, C.S.3
  • 44
    • 80055043200 scopus 로고    scopus 로고
    • Structural basis for broad neutralization of hepatitis C virus quasispecies
    • Lapierre P, Troesch M, Alvarez F, Soudeyns H. Structural basis for broad neutralization of hepatitis C virus quasispecies. PLoS ONE 6: 2011; e26981.
    • (2011) PLoS ONE , vol.6 , pp. e26981
    • Lapierre, P.1    Troesch, M.2    Alvarez, F.3    Soudeyns, H.4
  • 45
    • 80052894158 scopus 로고    scopus 로고
    • Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus
    • Meunier JC, Gottwein JM, HoughtonMet al. Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus. J Infect Dis 2011; 204: 1186-1190.
    • (2011) J Infect Dis , vol.204 , pp. 1186-1190
    • Meunier, J.C.1    Gottwein, J.M.2    Houghton, M.3
  • 46
    • 80051721226 scopus 로고    scopus 로고
    • Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains
    • Stamataki Z, Coates S, Abrignani S, Houghton M, McKeating JA. Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains. J Infect Dis 2011; 204: 811-813.
    • (2011) J Infect Dis , vol.204 , pp. 811-813
    • Stamataki, Z.1    Coates, S.2    Abrignani, S.3    Houghton, M.4    McKeating, J.A.5
  • 47
    • 84875122982 scopus 로고    scopus 로고
    • A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans
    • Law JL, Chen C, Wong J et al. A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans. PLoS ONE 2013; 8: e59776.
    • (2013) PLoS ONE , vol.8 , pp. e59776
    • Law, J.L.1    Chen, C.2    Wong, J.3
  • 48
    • 78650048403 scopus 로고    scopus 로고
    • Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission
    • Brimacombe CL, Grove J, Meredith LW et al. Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. J Virol 2011; 85: 596-605.
    • (2011) J Virol , vol.85 , pp. 596-605
    • Brimacombe, C.L.1    Grove, J.2    Meredith, L.W.3
  • 49
    • 84883213683 scopus 로고    scopus 로고
    • An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission
    • Tarr AW, Lafaye P, Meredith L et al. An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission. Hepatology 2013; 58: 932-939.
    • (2013) Hepatology , vol.58 , pp. 932-939
    • Tarr, A.W.1    Lafaye, P.2    Meredith, L.3
  • 50
    • 84877957589 scopus 로고    scopus 로고
    • A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits hepatitis C virus cell-cell transmission
    • Fofana I, Xiao F, Thumann C et al. A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits hepatitis C virus cell-cell transmission. PLoS ONE 2013; 8: e64221.
    • (2013) PLoS ONE , vol.8 , pp. e64221
    • Fofana, I.1    Xiao, F.2    Thumann, C.3
  • 51
    • 84887120904 scopus 로고    scopus 로고
    • Public Health Agency of Canada Ottawa: PHAS, 2006. Available at (accessed 1 July, 2013)
    • Public Health Agency of Canada. Canadian Immunization Guide. Ottawa: PHAS, 2006. Available at http://www.phac-aspc.gc.ca (accessed 1 July 2013).
    • Canadian Immunization Guide
  • 52
    • 84880575939 scopus 로고    scopus 로고
    • Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice
    • e1-4
    • Akazawa D, Moriyama M, Yokokawa H et al. Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice. Gastroenterology 2013; 145: 447-455.e1-4.
    • (2013) Gastroenterology , vol.145 , pp. 447-455
    • Akazawa, D.1    Moriyama, M.2    Yokokawa, H.3
  • 53
    • 80655142481 scopus 로고    scopus 로고
    • HepG2 cells expressing microRNA miR-122 support the entire hepatitis C virus life cycle
    • Narbus CM, Israelow B, Sourisseau M et al. HepG2 cells expressing microRNA miR-122 support the entire hepatitis C virus life cycle. J Virol 2011; 85: 12087-12092.
    • (2011) J Virol , vol.85 , pp. 12087-12092
    • Narbus, C.M.1    Israelow, B.2    Sourisseau, M.3
  • 54
    • 84869025358 scopus 로고    scopus 로고
    • Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells
    • da Costa D, Turek M, Felmlee DJ et al. Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells. J Virol 2012; 86: 11919-11925.
    • (2012) J Virol , vol.86 , pp. 11919-11925
    • Da Costa, D.1    Turek, M.2    Felmlee, D.J.3
  • 55
    • 84888285942 scopus 로고    scopus 로고
    • Human serum leads to differentiation of human hepatoma cells, restoration of VLDL secretion and a 1000-fold increase in HCV JFH-1 titers
    • Steenbergen RH, Joyce MA, Thomas BS et al. Human serum leads to differentiation of human hepatoma cells, restoration of VLDL secretion and a 1000-fold increase in HCV JFH-1 titers. Hepatology 2013; doi:10.1002/hep.26566.
    • (2013) Hepatology
    • Steenbergen, R.H.1    Joyce, M.A.2    Thomas, B.S.3
  • 56
    • 79961221361 scopus 로고    scopus 로고
    • A prime-boost strategy using virus-like particles pseudotyped for HCV proteins triggers broadly neutralizing antibodies in macaques
    • Garrone P, Fluckiger AC, Mangeot PE et al. A prime-boost strategy using virus-like particles pseudotyped for HCV proteins triggers broadly neutralizing antibodies in macaques. Sci Transl Med 2011; 3: 94-71.
    • (2011) Sci Transl Med , vol.3 , pp. 94-171
    • Garrone, P.1    Fluckiger, A.C.2    Mangeot, P.E.3
  • 57
    • 0032832514 scopus 로고    scopus 로고
    • Recurrence of hepatitis C virus after loss of virus-specific CD41 T-cell response in acute hepatitis C
    • Gerlach JT, Diepolder HM, Jung MC et al. Recurrence of hepatitis C virus after loss of virus-specific CD41 T-cell response in acute hepatitis C. Gastroenterology 1999; 117: 933-941.
    • (1999) Gastroenterology , vol.117 , pp. 933-941
    • Gerlach, J.T.1    Diepolder, H.M.2    Jung, M.C.3
  • 58
    • 0033119925 scopus 로고    scopus 로고
    • Analysis of a successful immune response against hepatitis C virus
    • Cooper S, Erickson AL, Adams EJ et al. Analysis of a successful immune response against hepatitis C virus. Immunity 1999; 10: 439-449.
    • (1999) Immunity , vol.10 , pp. 439-449
    • Cooper, S.1    Erickson, A.L.2    Adams, E.J.3
  • 59
    • 9844267962 scopus 로고    scopus 로고
    • Clinical outcome of hypogammaglobulinaemic patients following outbreak of acute hepatitis C: 2 year follow up
    • Christie JM, Healey CJ, Watson J et al. Clinical outcome of hypogammaglobulinaemic patients following outbreak of acute hepatitis C: 2 year follow up. Clin Exp Immunol 1997; 110: 4-8.
    • (1997) Clin Exp Immunol , vol.110 , pp. 4-8
    • Christie, J.M.1    Healey, C.J.2    Watson, J.3
  • 60
    • 2442663864 scopus 로고    scopus 로고
    • Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort
    • Post JJ, Pan Y, Freeman AJ et al. Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort. J Infect Dis 2004; 189: 1846-1855.
    • (2004) J Infect Dis , vol.189 , pp. 1846-1855
    • Post, J.J.1    Pan, Y.2    Freeman, A.J.3
  • 61
    • 84855388574 scopus 로고    scopus 로고
    • Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man
    • Barnes E, Folgori A, Capone S et al. Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man. Sci Transl Med 2012; 4: 115-1.
    • (2012) Sci Transl Med , vol.4 , pp. 115-121
    • Barnes, E.1    Folgori, A.2    Capone, S.3
  • 62
    • 32244435842 scopus 로고    scopus 로고
    • A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
    • Folgori A, Capone S, Ruggeri L et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat Med 2006; 12: 190-197.
    • (2006) Nat Med , vol.12 , pp. 190-197
    • Folgori, A.1    Capone, S.2    Ruggeri, L.3
  • 64
    • 0035284757 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine
    • Polakos NK, Drane D, Cox J et al. Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine. J Immunol 2001; 166: 3589-3598.
    • (2001) J Immunol , vol.166 , pp. 3589-3598
    • Polakos, N.K.1    Drane, D.2    Cox, J.3
  • 65
    • 67549123833 scopus 로고    scopus 로고
    • Priming of CD41 and CD81 T cell responses using a HCV core ISCOMATRIX vaccine: A phase i study in healthy volunteers
    • Drane D, Maraskovsky E, Gibson R et al. Priming of CD41 and CD81 T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers. Hum Vaccin 2009; 5: 151-157.
    • (2009) Hum Vaccin , vol.5 , pp. 151-157
    • Drane, D.1    Maraskovsky, E.2    Gibson, R.3
  • 66
    • 80051490030 scopus 로고    scopus 로고
    • A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C
    • Habersetzer F, Honnet G, Bain C et al. A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C. Gastroenterology 2011; 141: 890-899.
    • (2011) Gastroenterology , vol.141 , pp. 890-899
    • Habersetzer, F.1    Honnet, G.2    Bain, C.3
  • 67
    • 84890123431 scopus 로고    scopus 로고
    • Significant improvement of complete EVR in HCVac phase II clinical trial when adding TG4040 therapeutic vaccine to PegIFNa2a and ribavirin
    • Wedemeyer H, Janczewska-Kazek E, WlodzimierzMet al. Significant improvement of complete EVR in HCVac phase II clinical trial when adding TG4040 therapeutic vaccine to PegIFNa2a and ribavirin. J Hepatol 2012; 56(Suppl 2): S552.
    • (2012) J Hepatol , vol.56 , pp. S552
    • Wedemeyer, H.1    Janczewska-Kazek, E.2    Wlodzimierz, M.3
  • 70
    • 84957598368 scopus 로고    scopus 로고
    • Liver cancer on the rise
    • Canadian Cancer Society Available at (accessed 1 July, 2013)
    • Canadian Cancer Society. Liver cancer on the rise. Toronto: CCS, 2013. Available at http://www.cancer.ca (accessed 1 July 2013).
    • (2013) Toronto: CCS
  • 72
    • 84867288022 scopus 로고    scopus 로고
    • Recommendations for the identification of chronic hepatitis c virus infection among persons born during 1945-1965
    • RR
    • Smith BD, Morgan RL, Beckett GA et al. Recommendations for the Identification of Chronic Hepatitis C Virus Infection Among Persons Born During 1945-1965. MMWR Recomm Rep 2012; 61 (RR-4): 1-32.
    • (2012) MMWR Recomm Rep , vol.61 , Issue.4 , pp. 1-32
    • Smith, B.D.1    Morgan, R.L.2    Beckett, G.A.3
  • 74
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009; 461: 798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3
  • 75
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009; 41: 1100-1104.
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 76
    • 3843075120 scopus 로고    scopus 로고
    • HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    • Khakoo SI, Thio CL, Martin MP et al. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 2004; 305: 872-874.
    • (2004) Science , vol.305 , pp. 872-874
    • Khakoo, S.I.1    Thio, C.L.2    Martin, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.