A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine

Molecular BioSystems

Volumn 11, Issue 2, 2015, Pages 463-474

  Gu, Shenghua ^a,b,c   Cao, Bei ^a,d   Sun, Runbin ^a   Tang, Yueqing ^b   Paletta, Janice L ^c   Wu, Xiao Lei ^b   Liu, Linsheng ^a   Zha, Weibin ^a   Zhao, Chunyan ^a   Li, Yan ^b   Radlon, Jason M ^e   Hylemon, Phillip B ^e   Zhou, Huiping ^e   Aa, Jiye ^a   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CRICETINAE;

ANTILIPEMIC AGENT; BERBERINE; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; LIPID; MESSENGER RNA;

ANIMAL; BLOOD; BODY WEIGHT; DRUG EFFECTS; GALLBLADDER; GAS CHROMATOGRAPHY; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; HUMAN; HYPERLIPIDEMIAS; LIPID DIET; LIVER; MALE; MASS SPECTROMETRY; MESOCRICETUS; METABOLISM; METABOLOMICS; MICROFLORA; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; BERBERINE; BODY WEIGHT; CHOLESTANETRIOL 26-MONOOXYGENASE; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLIC ACID; CHROMATOGRAPHY, GAS; DIET, HIGH-FAT; GALLBLADDER; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HUMANS; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; LIPIDS; LIVER; MALE; MASS SPECTROMETRY; MESOCRICETUS; METABOLOMICS; MICROBIOTA; RNA, MESSENGER;

EID: 84921465991     PISSN: 1742206X     EISSN: 17422051     Source Type: Journal    
DOI: 10.1039/c4mb00500g     Document Type: Article

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