Metabolic features of the tumor microenvironment of gastric cancer and the link to the systemic macroenvironment

Metabolomics

Volumn 8, Issue 1, 2012, Pages 164-173

  Aa, Jiye ^a   Yu, Lianzhen ^b   Sun, Min ^c   Liu, Linsheng ^a   Li, Mengjie ^a   Cao, Bei ^a   Shi, Jan ^a   Xu, Jin ^b   Cheng, Liping ^d   Zhou, Jun ^a   Zheng, Tian ^a   Wang, Xinwen ^a   Zhao, Chunyan ^a   Gu, Rongrong ^a   Zhang, Fengyi ^a   Shi, Ruihua ^b   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c Suzhou Medical College of Soochow University   (China)

^d China   (China)

Author keywords

Gastric cancer; Metabolic phenotype; Metabolomics; Tricarboxylic acid cycle; Tumor microenvironment

Indexed keywords

AMINO ACID; FATTY ACID; GLUCOSE; LACTIC ACID; TUMOR MARKER;

AMINO ACID METABOLISM; ARTICLE; BLOOD LEVEL; CANCER SURGERY; CHRONIC SUPERFICIAL GASTRITIS; CITRIC ACID CYCLE; CONTROLLED STUDY; DIGESTIVE SYSTEM INFLAMMATION; GLYCOLYSIS; HUMAN; HUMAN TISSUE; MASS FRAGMENTOGRAPHY; METABOLITE; METABOLOMICS; POSTOPERATIVE PERIOD; STOMACH CANCER; TISSUE LEVEL; TUMOR MICROENVIRONMENT;

EID: 84855884306     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-011-0297-0     Document Type: Article

References (18)

1. Aa, J., Trygg, J., Gullberg, J., et al. (2005). Extraction and GC/MS analysis of the human blood plasma metabolome. Analytical Chemistry, 77, 8086-8094.
2. Ahn, J., Park, I. S., Lee, K. S., et al. (2001). Fatty acid patterns in gastric mucosa of stomach cancer patients. Yonsei Medical Journal, 42, 220-226.
3. Averous, J., & Proud, C. G. (2006). When translation meets transformation: The mTOR story. Oncogene, 25, 6423-6435.
4. Clemens, M. J. (2004). Targets and mechanisms for the regulation of translation in malignant transformation. Oncogene, 23, 3180-3188.
5. Denkert, C., Budczies, J., Weichert, W., et al. (2008). Metabolite profiling of human colon carcinoma-deregulation of TCA cycle and amino acid turnover. Mol Cancer, 7, 72.
6. Gatenby, R. A., & Gillies, R. J. (2004). Why do cancers have high aerobic glycolysis? Nature Reviews Cancer, 4, 891-899.
7. Gu, S., Aa, J., Wang, G., et al. (2010). Metabonomic profiling of liver metabolites by gas chromatography-mass spectrometry and its application to characterizing hyperlipidemia. Biomedical Chromatography, 24, 243-252.
8. Hirayama, A., Kami, K., Sugimoto, M., et al. (2009). Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Research, 69, 4918-4925.
9. Jonsson, P., Johansson, A. I., Gullberg, J., et al. (2005). High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses. Analytical Chemistry, 77, 5635-5642.
10. Kuhajda, F. P. (2000). Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology. Nutrition, 16, 202-208.
11. Milgraum, L. Z., Witters, L. A., Pasternack, G. R., et al. (1997). Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clinical Cancer Research, 3, 2115-2120.
12. Parkin, D. M., Bray, F., Ferlay, J., et al. (2005). Global cancer statistics, 2002. CA Cancer J Clinicians, 55, 74-108.
13. Rahman, L., Voeller, D., Rahman, M., et al. (2004). Thymidylate synthase as an oncogene: A novel role for an essential DNA synthesis enzyme. Cancer Cell, 5, 341-351.
14. Trygg, J., Holmes, E., & Lundstedt, T. (2007). Chemometrics in metabonomics. Journal of Proteome Research, 6, 469-479.
15. Voeller, D., Rahman, L., & Zajac-Kaye, M. (2004). Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells. Cell Cycle, 3, 1005-1007.
16. Warburg, O. (1956). On the origin of cancer cells. Science, 123, 309-314.
17. Weber, G., Singhal, R. L., Stamm, N. B., et al. (1966). Synchronous behavior pattern of key glycolytic enzymes: Glucokinase, phosphofructokinase, and pyruvate kinase. Advances in Enzyme Regulation, 4, 59-81.
18. Zha, W., Aa, J., Wang, G., et al. (2009). Metabonomic characterization of early atherosclerosis in hamsters with induced cholesterol. Biomarkers, 14, 372-380.