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Volumn 23, Issue 3, 2015, Pages 499-514

Anthranilic acid derivatives as nuclear receptor modulators - Development of novel PPAR selective and dual PPAR/FXR ligands

(7) Merk, Daniel a Lamers, Christina a Weber, Julia a Flesch, Daniel a Gabler, Matthias a Proschak, Ewgenij a Schubert Zsilavecz, Manfred a

a GOETHE UNIVERSITY (Germany)

Author keywords

Farnesoid X receptor (FXR); Metabolic disorders Lipid metabolism; Nuclear receptors; Peroxisome proliferator activated receptors (PPAR)

Indexed keywords

2 [3 [2 (2 NAPHTHAMIDO)BENZAMIDO]PHENYL]ACETIC ACID; 2 [3 [2 (3,4 DIMETHOXYBENZAMIDO)BENZAMIDO]PHENYL]ACETIC ACID; 2 [3 [2 (4 CYANOBENZAMIDO)BENZAMIDO]PHENYL]ACETIC ACID; 2 [3 [2 (4 METHOXYBENZAMIDO)BENZAMIDO]PHENYL]ACETIC ACID; 2 [3 [2 ([1,1' BIPHENYL] 4 CARBOXAMIDO)BENZAMIDO]PHENYL]ACETIC ACID; 2 [3 [2 [4 (METHYLTHIO)BENZAMIDO]BENZAMIDO]PHENYL]ACETIC ACID; 2 [3 [2 [4 (TRIFLUOROMETHYL)BENZAMIDO]BENZAMIDO]PHENYL]ACETIC ACID; 2 [3 [2 [4 [(TRIFLUOROMETHYL)THIO]BENZAMIDO]BENZAMIDO]PHENYL]ACETIC ACID; 3 [3 [2 [4 (TRIFLUOROMETHYL)BENZAMIDO]BENZAMIDO]PHENYL]PROPANOIC ACID; 3 [4 CHLORO 2 [4 (TRIFLUOROMETHYL)BENZAMIDO]BENZAMIDO]BENZOIC ACID; 3 [5 CHLORO 2 [4 (TRIFLUOROMETHYL)BENZAMIDO]BENZAMIDO]BENZOIC ACID; 3 [6 CHLORO 2 [4 (TRIFLUOROMETHYL)BENZAMIDO]BENZAMIDO]BENZOIC ACID; ANTHRANILIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; UNCLASSIFIED DRUG; ANTHRANILIC ACID; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ARTICLE; CHLORINATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIGAND BINDING; LIPID HOMEOSTASIS; LIPOPHILICITY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; AGONISTS; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; LIPID METABOLISM;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; LIGANDS; LIPID METABOLISM; ORTHO-AMINOBENZOATES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84921405759 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.12.013 Document Type: Article

Times cited : (26)

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