Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Batista, Fernanda A H ^a   Trivella, Daniela B B ^a,d   Bernardes, Amanda ^a   Gratieri, Joyce ^a   Oliveira, Paulo S L ^b   Figueira, Ana Carolina M ^b   Webb, Paul ^c   Polikarpov, Igor ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

[4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; BEZAFIBRATE; INDEGLITAZAR; LEUCINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; VALINE; LIGAND; RECOMBINANT PROTEIN; THIAZOLE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; PROTEIN FUNCTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; BINDING SITE; CELL STRAIN HEPG2; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; GENETICS; METABOLISM; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HEP G2 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PPAR ALPHA; PPAR DELTA; PPAR GAMMA; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; THIAZOLES;

EID: 84861005876     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033643     Document Type: Article

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