Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 8, 2014, Pages 2447-2460

  Merk, Daniel ^a   Gabler, Matthias ^a   Gomez, Roberto Carrasco ^a,b   Flesch, Daniel ^a   Hanke, Thomas ^a   Kaiser, Astrid ^a   Lamers, Christina ^a   Werz, Oliver ^c   Schneider, Gisbert ^b   Schubert Zsilavecz, Manfred ^a  

^a GOETHE UNIVERSITY   (Germany)

^b ETH ZURICH   (Switzerland)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Bile acids; Farnesoid X receptor; Glucose homeostasis; Metabolic disorder; Nuclear receptor

Indexed keywords

2 [4 [2 (2 NAPHTHAMIDO)BENZAMIDO]PHENYL]ACETIC ACID; 3 [2 (2 NAPHTHAMIDO)BENZAMIDO]BENZOIC ACID; 4 (2 CINNAMAMIDOBENZAMIDO)BUTANOIC ACID; 4 [2 (1 NAPHTHAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (2 NAPHTHAMIDO) N METHYLBENZAMIDO]BUTANOIC ACID; 4 [2 (2 NAPHTHAMIDO)BENZAMIDO]BENZOIC ACID; 4 [2 (2 NAPHTHAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (2,2 DIPHENYLACETAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (3 PHENYLPROPANAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (3,3 DIPHENYLPROPANAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (3,5 DINITROBENZAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (4 ETHYLBENZAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (4 METHOXYBENZAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (ISONICOTINAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (N METHYL 2 NAPHTHAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (NAPHTHALENE 2 SULFONAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 (THIOPHENE 2 CARBOXAMIDO)BENZAMIDO]BUTANOIC ACID; 4 [2 [(1,1' BIPHENYL) 2 CARBOXAMIDO]BENZAMIDO]BUTANOIC ACID; 4 [2 [(1,1' BIPHENYL) 3 CARBOXAMIDO]BENZAMIDO]BUTANOIC ACID; 4 [2 [(1,1' BIPHENYL) 4 CARBOXAMIDO]BENZAMIDO]BUTANOIC ACID; 4 [2 [2 (NAPHTHALEN 2 YL)ACETAMIDO]BENZAMIDO]BUTANOIC ACID; 4 [2 [4 (TERT BUTYL)BENZAMIDO]BENZAMIDO]BUTANOIC ACID; 4 [[2 (2 NAPHTHAMIDO)BENZAMIDO]METHYL]BENZOIC ACID; 5 [2 (2 NAPHTHAMIDO)BENZAMIDO]PENTANOIC ACID; 6 [2 (2 NAPHTHAMIDO)BENZAMIDO]HEXANOIC ACID; ANTHRANILIC ACID DERIVATIVE; BUTYRIC ACID DERIVATIVE; FARNESOID X RECEPTOR; METHYL 4 [2 (2 NAPHTHAMIDO)BENZAMIDO]BUTANOATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTHRANILIC ACID; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; LIGAND; PROTEIN BINDING;

ARTICLE; CELL STRAIN HEPG2; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; AGONISTS; BINDING SITE; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

BINDING SITES; LIGANDS; MOLECULAR DOCKING SIMULATION; ORTHO-AMINOBENZOATES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897988277     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.02.053     Document Type: Article

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