메뉴 건너뛰기




Volumn 14, Issue 2, 2014, Pages 195-204

Electroporation-enhanced delivery of nucleic acid vaccines

Author keywords

DNA vaccine; electroporation; electrotransfer; RNA vaccine

Indexed keywords

CANCER VACCINE; DNA VACCINE; RNA VACCINE;

EID: 84921405665     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.2015.990890     Document Type: Review
Times cited : (61)

References (106)
  • 1
    • 79957781340 scopus 로고    scopus 로고
    • Electroporation delivery of DNA vaccines: Prospects for success
    • Sardesai NY, Weiner DB. Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 2011;23(3): 421-9
    • (2011) Curr Opin Immunol , vol.23 , Issue.3 , pp. 421-429
    • Sardesai, N.Y.1    Weiner, D.B.2
  • 2
    • 84906893398 scopus 로고    scopus 로고
    • Editorial: The coming of age of DNA vaccines
    • Petrovsky N. Editorial: the coming of age of DNA vaccines. Curr Gene Ther 2014; 14(3):147-8
    • (2014) Curr Gene Ther , vol.14 , Issue.3 , pp. 147-148
    • Petrovsky, N.1
  • 3
    • 0028819916 scopus 로고
    • Gene gun-based nucleic acid immunization: Elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA
    • Pertmer TM, Eisenbraun MD, McCabe D, et al. Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 1995;13(15):1427-30
    • (1995) Vaccine , vol.13 , Issue.15 , pp. 1427-1430
    • Pertmer, T.M.1    Eisenbraun, M.D.2    McCabe, D.3
  • 4
    • 33748856603 scopus 로고    scopus 로고
    • Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases
    • Fuller DH, Loudon P, Schmaljohn C. Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases. Methods (San Diego, Calif.) 2006;40(1):86-97
    • (2006) Methods (San Diego, Calif , vol.40 , Issue.1 , pp. 86-97
    • Fuller, D.H.1    Loudon, P.2    Schmaljohn, C.3
  • 5
    • 0020339802 scopus 로고
    • Gene transfer into mouse lyoma cells by electroporation in high electric fields
    • Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1982;1(7):841-5
    • (1982) EMBO J , vol.1 , Issue.7 , pp. 841-845
    • Neumann, E.1    Schaefer-Ridder, M.2    Wang, Y.3    Hofschneider, P.H.4
  • 6
    • 0021435480 scopus 로고
    • Stochastic model for electric field-induced membrane pores
    • Sugar IP, Neumann E. Stochastic model for electric field-induced membrane pores. Electroporat Biophysical Chem 1984;19(3): 211-25
    • (1984) Electroporat Biophysical Chem , vol.19 , Issue.3 , pp. 211-225
    • Sugar, I.P.1    Neumann, E.2
  • 8
    • 18144446323 scopus 로고    scopus 로고
    • Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
    • Baltimore, M.d.
    • Widera G, Austin M, Rabussay D, et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol (Baltimore, Md.: 1950) 2000; 164(9):4635-40
    • (2000) J Immunol , vol.164 , Issue.9 , pp. 4635-4640
    • Widera, G.1    Austin, M.2    Rabussay, D.3
  • 9
    • 33947432878 scopus 로고    scopus 로고
    • Plasmid-based gene therapy of diabetes mellitus
    • Prud'homme GJ, Draghia-Akli R, Wang Q. Plasmid-based gene therapy of diabetes mellitus. Gene Ther 2007;14(7):553-64
    • (2007) Gene Ther , vol.14 , Issue.7 , pp. 553-564
    • Prud'homme, G.J.1    Draghia-Akli, R.2    Wang, Q.3
  • 10
    • 2942564030 scopus 로고    scopus 로고
    • Enhancement of DNA vaccine potency in rhesus macaques by electroporation
    • Otten G, Schaefer M, Doe B, et al. Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine 2004;22(19):2489-93
    • (2004) Vaccine , vol.22 , Issue.19 , pp. 2489-2493
    • Otten, G.1    Schaefer, M.2    Doe, B.3
  • 11
    • 33646852606 scopus 로고    scopus 로고
    • Potent immunogenicity of an HIV-1 gagpol fusion DNA vaccine delivered by in vivo electroporation
    • Otten GR, Schaefer M, Doe B, et al. Potent immunogenicity of an HIV-1 gagpol fusion DNA vaccine delivered by in vivo electroporation. Vaccine 2006; 24(21):4503-9
    • (2006) Vaccine , vol.24 , Issue.21 , pp. 4503-4509
    • Otten, G.R.1    Schaefer, M.2    Doe, B.3
  • 12
    • 0032926935 scopus 로고    scopus 로고
    • Electropermeabilization of skeletal muscle enhances gene transfer in vivo
    • Mathiesen I. Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther 1999;6(4):508-14
    • (1999) Gene Ther , vol.6 , Issue.4 , pp. 508-514
    • Mathiesen, I.1
  • 13
    • 84865644203 scopus 로고    scopus 로고
    • Transport of siRNA through lipid membranes driven by nanosecond electric pulses: An experimental and computational study
    • Breton M, Delemotte L, Silve A, et al. Transport of siRNA through lipid membranes driven by nanosecond electric pulses: an experimental and computational study. J Am Chem Soc 2012;134(34):13938-41
    • (2012) J Am Chem Soc , vol.134 , Issue.34 , pp. 13938-13941
    • Breton, M.1    Delemotte, L.2    Silve, A.3
  • 14
    • 84921412924 scopus 로고    scopus 로고
    • Basic features of a cell electroporation model: Illustrative behavior for two very different pulses
    • Son RS, Smith KC, Gowrishankar TR, et al. Basic features of a cell electroporation model: illustrative behavior for two very different pulses. J Membr Biol 2014; 247(12):1209-28
    • (2014) J Membr Biol , vol.247 , Issue.12 , pp. 1209-1228
    • Son, R.S.1    Smith, K.C.2    Gowrishankar, T.R.3
  • 15
    • 84901300578 scopus 로고    scopus 로고
    • The state of irreversible electroporation in interventional oncology
    • Silk M, Tahour D, Srimathveeravalli G, et al. The state of irreversible electroporation in interventional oncology. Semin Intervent Radiol 2014;31(2):111-17
    • (2014) Semin Intervent Radiol , vol.31 , Issue.2 , pp. 111-117
    • Silk, M.1    Tahour, D.2    Srimathveeravalli, G.3
  • 16
    • 84863860429 scopus 로고    scopus 로고
    • Electrochemotherapy for large cutaneous recurrence of breast cancer: A phase II clinical trial
    • Matthiessen LW, Johannesen HH, Hendel HW, et al. Electrochemotherapy for large cutaneous recurrence of breast cancer: a phase II clinical trial. Acta Oncol 2012; 51(6):713-21
    • (2012) Acta Oncol , vol.51 , Issue.6 , pp. 713-721
    • Matthiessen, L.W.1    Johannesen, H.H.2    Hendel, H.W.3
  • 17
    • 0025231388 scopus 로고
    • Direct gene transfer into mouse muscle in vivo
    • Pt 1
    • Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science (New York, N.Y.) 1990; 247(4949 Pt 1):1465-8
    • (1990) Science New York N.Y. , vol.247 , Issue.4949 , pp. 1465-1468
    • Wolff, J.A.1    Malone, R.W.2    Williams, P.3
  • 19
    • 0029905441 scopus 로고    scopus 로고
    • Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
    • Isaka Y, Brees DK, Ikegaya K, et al. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nature Med 1996;2(4):418-23
    • (1996) Nature Med , vol.2 , Issue.4 , pp. 418-423
    • Isaka, Y.1    Brees, D.K.2    Ikegaya, K.3
  • 20
    • 0031910791 scopus 로고    scopus 로고
    • In vivo electrically mediated protein and gene transfer in murine melanoma
    • Rols MP, Delteil C, Golzio M, et al. In vivo electrically mediated protein and gene transfer in murine melanoma. Nature Biotechnol 1998;16(2):168-71
    • (1998) Nature Biotechnol , vol.16 , Issue.2 , pp. 168-171
    • Rols, M.P.1    Delteil, C.2    Golzio, M.3
  • 21
    • 9044230116 scopus 로고    scopus 로고
    • High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation
    • Nishi T, Yoshizato K, Yamashiro S, et al. High-efficiency in vivo gene transfer using intraarterial plasmid DNA injection following in vivo electroporation. Cancer Res 1996;56(5):1050-5
    • (1996) Cancer Res , vol.56 , Issue.5 , pp. 1050-1055
    • Nishi, T.1    Yoshizato, K.2    Yamashiro, S.3
  • 22
    • 0030575192 scopus 로고    scopus 로고
    • In vivo gene electroinjection and expression in rat liver
    • Heller R, Jaroszeski M, Atkin A, et al. In vivo gene electroinjection and expression in rat liver. FEBS Lett 1996; 389(3):225-8
    • (1996) FEBS Lett , vol.389 , Issue.3 , pp. 225-228
    • Heller, R.1    Jaroszeski, M.2    Atkin, A.3
  • 23
    • 0031753867 scopus 로고    scopus 로고
    • Gene transfer into muscle by electroporation in vivo
    • Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nature Biotechnol 1998;16(9):867-70
    • (1998) Nature Biotechnol , vol.16 , Issue.9 , pp. 867-870
    • Aihara, H.1    Miyazaki, J.2
  • 24
    • 76949084636 scopus 로고    scopus 로고
    • Production of pharmaceutical-grade plasmids at high concentration and high supercoiled percentage
    • Cai Y, Rodriguez S, Rameswaran R, et al. Production of pharmaceutical-grade plasmids at high concentration and high supercoiled percentage. Vaccine 2010;28(8): 2046-52
    • (2010) Vaccine , vol.28 , Issue.8 , pp. 2046-2052
    • Cai, Y.1    Rodriguez, S.2    Rameswaran, R.3
  • 26
    • 79960750673 scopus 로고    scopus 로고
    • Clinical applications of DNA vaccines: Current progress
    • Ferraro B, Morrow MP, Hutnick NA, et al. Clinical applications of DNA vaccines: current progress. Clin Infect Dis 2011; 53(3):296-302
    • (2011) Clin Infect Dis , vol.53 , Issue.3 , pp. 296-302
    • Ferraro, B.1    Morrow, M.P.2    Hutnick, N.A.3
  • 27
    • 84868195386 scopus 로고    scopus 로고
    • Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model
    • Shen X, Söderholm J, Lin F, et al. Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model. Vaccine 2012;30(48):6946-54
    • (2012) Vaccine , vol.30 , Issue.48 , pp. 6946-6954
    • Shen, X.1    Söderholm, J.2    Lin, F.3
  • 28
    • 84903908289 scopus 로고    scopus 로고
    • Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines
    • Walters AA, Kinnear E, Shattock RJ, et al. Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines. Gene Ther 2014;21(7):645-52
    • (2014) Gene Ther , vol.21 , Issue.7 , pp. 645-652
    • Walters, A.A.1    Kinnear, E.2    Shattock, R.J.3
  • 31
    • 84921403853 scopus 로고    scopus 로고
    • Available from
    • FDA. Available from: www.fda.gov
    • FDA
  • 32
    • 0035051928 scopus 로고    scopus 로고
    • West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays
    • Davis BS, Chang GJ, Cropp B, et al. West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 2001;75(9):4040-7
    • (2001) J Virol , vol.75 , Issue.9 , pp. 4040-4047
    • Davis, B.S.1    Chang, G.J.2    Cropp, B.3
  • 33
    • 0030158621 scopus 로고    scopus 로고
    • Genetic immunization of rainbow trout (Oncorhynchus mykiss) against infectious hematopoietic necrosis virus
    • Anderson ED, Mourich DV, Fahrenkrug SC, et al. Genetic immunization of rainbow trout (Oncorhynchus mykiss) against infectious hematopoietic necrosis virus. Mol Marine Biol Biotechnol 1996;5(2):114-22
    • (1996) Mol Marine Biol Biotechnol , vol.5 , Issue.2 , pp. 114-122
    • Anderson, E.D.1    Mourich, D.V.2    Fahrenkrug, S.C.3
  • 34
    • 0037389779 scopus 로고    scopus 로고
    • Long-Term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: A phase i trial
    • Bergman PJ, McKnight J, Novosad A, et al. Long-Term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial. Clin Cancer Res 2003;9(4):1284-90
    • (2003) Clin Cancer Res , vol.9 , Issue.4 , pp. 1284-1290
    • Bergman, P.J.1    McKnight, J.2    Novosad, A.3
  • 35
    • 84873613014 scopus 로고    scopus 로고
    • Available from
    • Gene designer. Available from: www.dna20. com/resources/genedesigner
    • Gene Designer
  • 36
    • 38549175830 scopus 로고    scopus 로고
    • DNA vaccines: Precision tools for activating effective immunity against cancer
    • Rice J, Ottensmeier CH, Stevenson FK. DNA vaccines: precision tools for activating effective immunity against cancer. Nature Rev Cancer 2008;8(2):108-20
    • (2008) Nature Rev Cancer , vol.8 , Issue.2 , pp. 108-120
    • Rice, J.1    Ottensmeier, C.H.2    Stevenson, F.K.3
  • 38
    • 34250721613 scopus 로고    scopus 로고
    • Pre-clinical evaluation of a CEA DNA prime/protein boost vaccination strategy against colorectal cancer
    • Hallermalm K, Johansson S, Bråve A, et al. Pre-clinical evaluation of a CEA DNA prime/protein boost vaccination strategy against colorectal cancer. Scand J Immunol 2007;66(1):43-51
    • (2007) Scand J Immunol , vol.66 , Issue.1 , pp. 43-51
    • Hallermalm, K.1    Johansson, S.2    Bråve, A.3
  • 39
    • 84886945450 scopus 로고    scopus 로고
    • HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model: Gene gun is superior to jet injector in inducing CTL responses and protective immunity
    • Nguyen-Hoai T, Kobelt D, Hohn O, et al. HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model: gene gun is superior to jet injector in inducing CTL responses and protective immunity. Oncoimmunol 2012;1(9):1537-45
    • (2012) Oncoimmunol , vol.1 , Issue.9 , pp. 1537-1545
    • Nguyen-Hoai, T.1    Kobelt, D.2    Hohn, O.3
  • 40
    • 68349152636 scopus 로고    scopus 로고
    • Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery
    • Best SR, Peng S, Juang C-MM, et al. Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery. Vaccine 2009;27(40):5450-9
    • (2009) Vaccine , vol.27 , Issue.40 , pp. 5450-5459
    • Best, S.R.1    Peng, S.2    Juang, C.-M.M.3
  • 41
    • 84911495682 scopus 로고    scopus 로고
    • Microneedle patches for vaccine delivery
    • Suh H, Shin J, Kim Y-CC. Microneedle patches for vaccine delivery. Clin Exp Vaccine Res 2014;3(1):42-9
    • (2014) Clin Exp Vaccine Res , vol.3 , Issue.1 , pp. 42-49
    • Suh, H.1    Shin, J.2    Kim, Y.-C.C.3
  • 43
    • 84869206956 scopus 로고    scopus 로고
    • Mechanisms of action underlying the immunotherapeutic activity of Allovectin in advanced melanoma
    • Doukas J, Rolland A. Mechanisms of action underlying the immunotherapeutic activity of Allovectin in advanced melanoma. Cancer Gene Ther 2012;19(12):811-17
    • (2012) Cancer Gene Ther , vol.19 , Issue.12 , pp. 811-817
    • Doukas, J.1    Rolland, A.2
  • 44
    • 84934443935 scopus 로고    scopus 로고
    • Clinical development of intramuscular electroporation: Providing a boost for DNA vaccines
    • Clifton, N.J.
    • Khan AS, Broderick KE, Sardesai NY. Clinical development of intramuscular electroporation: providing a boost for DNA vaccines. Methods Mol Biol (Clifton, N.J.) 2014;1121:279-89
    • (2014) Methods Mol Biol , vol.1121 , pp. 279-289
    • Khan, A.S.1    Broderick, K.E.2    Sardesai, N.Y.3
  • 45
    • 84856969117 scopus 로고    scopus 로고
    • Safety and tolerability of the Easy VaxTM clinical epidermal electroporation system in healthy adults
    • El-Kamary SS, Billington M, Deitz S, et al. Safety and tolerability of the Easy VaxTM clinical epidermal electroporation system in healthy adults. Mol Ther 2012;20(1):214-20
    • (2012) Mol Ther , vol.20 , Issue.1 , pp. 214-220
    • El-Kamary, S.S.1    Billington, M.2    Deitz, S.3
  • 46
    • 0034536936 scopus 로고    scopus 로고
    • In vivo electroporation of plasmids encoding GM-CSF or interleukin-2 into existing B16 melanomas combined with electrochemotherapy induces long-Term antitumour immunity
    • Heller L, Pottinger C, Jaroszeski MJ, et al. In vivo electroporation of plasmids encoding GM-CSF or interleukin-2 into existing B16 melanomas combined with electrochemotherapy induces long-Term antitumour immunity. Melanoma Res 2000; 10(6):577-83
    • (2000) Melanoma Res , vol.10 , Issue.6 , pp. 577-583
    • Heller, L.1    Pottinger, C.2    Jaroszeski, M.J.3
  • 47
    • 84904488906 scopus 로고    scopus 로고
    • Evaluation of thermal injury to liver, pancreas and kidney during irreversible electroporation in an in vivo experimental model
    • Dunki-Jacobs EM, Philips P, Martin Ii RC. Evaluation of thermal injury to liver, pancreas and kidney during irreversible electroporation in an in vivo experimental model. Br J Surg 2014;101(9):1113-21
    • (2014) Br J Surg , vol.101 , Issue.9 , pp. 1113-1121
    • Dunki-Jacobs, E.M.1    Philips, P.2    Martin Ii, R.C.3
  • 48
    • 84906905584 scopus 로고    scopus 로고
    • Progress of in vivo electroporation in the rodent brain
    • Ding X-FF, Ma D-LL, Zhang Q, et al. Progress of in vivo electroporation in the rodent brain. Curr Gene Ther 2014;14(3):211-17
    • (2014) Curr Gene Ther , vol.14 , Issue.3 , pp. 211-217
    • Ding, X.-F.F.1    Ma, D.-L.L.2    Zhang, Q.3
  • 49
    • 61749095949 scopus 로고    scopus 로고
    • Bleomycin treatment of brain tumors: An evaluation
    • Linnert M, Gehl J. Bleomycin treatment of brain tumors: an evaluation. Anti Cancer Drugs 2009;20(3):157-64
    • (2009) Anti Cancer Drugs , vol.20 , Issue.3 , pp. 157-164
    • Linnert, M.1    Gehl, J.2
  • 50
    • 84885135914 scopus 로고    scopus 로고
    • Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses
    • Kichaev G, Mendoza JM, Amante D, et al. Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses. Human Vaccines Immunother 2013;9(10):2041-8
    • (2013) Human Vaccines Immunother , vol.9 , Issue.10 , pp. 2041-2048
    • Kichaev, G.1    Mendoza, J.M.2    Amante, D.3
  • 51
    • 84885161878 scopus 로고    scopus 로고
    • Tolerability of intramuscular and intradermal delivery by CELLECTRA(-) adaptive constant current electroporation device in healthy volunteers
    • Diehl MC, Lee JC, Daniels SE, et al. Tolerability of intramuscular and intradermal delivery by CELLECTRA(-) adaptive constant current electroporation device in healthy volunteers. Human Vaccines Immunother 2013;9(10):2246-52
    • (2013) Human Vaccines Immunother , vol.9 , Issue.10 , pp. 2246-2252
    • Diehl, M.C.1    Lee, J.C.2    Daniels, S.E.3
  • 52
    • 75849124774 scopus 로고    scopus 로고
    • Available from
    • Clinical trials. Available from: www. clinicaltrials.gov
    • Clinical Trials
  • 53
    • 84902593489 scopus 로고    scopus 로고
    • Trial Watch: DNA vaccines for cancer therapy
    • Pol J, Bloy N, Obrist F, et al. Trial Watch: DNA vaccines for cancer therapy. Oncoimmunol 2014;3(1):e28185
    • (2014) Oncoimmunol , vol.3 , Issue.1 , pp. e28185
    • Pol, J.1    Bloy, N.2    Obrist, F.3
  • 58
    • 84881555063 scopus 로고    scopus 로고
    • DNA vaccine coding for the rhesus prostate specific antigen delivered by intradermal electroporation in patients with relapsed prostate cancer
    • Eriksson F, Tötterman T, Maltais A-KK, et al. DNA vaccine coding for the rhesus prostate specific antigen delivered by intradermal electroporation in patients with relapsed prostate cancer. Vaccine 2013; 31(37):3843-8
    • (2013) Vaccine , vol.31 , Issue.37 , pp. 3843-3848
    • Eriksson, F.1    Tötterman, T.2    Maltais, A.-K.K.3
  • 59
    • 84871011037 scopus 로고    scopus 로고
    • DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time
    • Chudley L, McCann K, Mander A, et al. DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time. Cancer Immunol Immunother 2012;61(11):2161-70
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.11 , pp. 2161-2170
    • Chudley, L.1    McCann, K.2    Mander, A.3
  • 60
    • 84874978904 scopus 로고    scopus 로고
    • Phase 1 studies of the safety and immunogenicity of electroporated HER2/ CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors
    • Diaz CM, Chiappori A, Aurisicchio L, et al. Phase 1 studies of the safety and immunogenicity of electroporated HER2/ CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors. J Transl Med 2013;11:62
    • (2013) J Transl Med , vol.11 , pp. 62
    • Diaz, C.M.1    Chiappori, A.2    Aurisicchio, L.3
  • 61
    • 84867437406 scopus 로고    scopus 로고
    • Immunotherapy Against HPV16/generates Potent TH1 and Cytotoxic Cellular Immune Responses
    • Bagarazzi ML, Yan J, Morrow MP, et al. Immunotherapy against HPV16/generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med 2012;4(155):155ra138
    • (2012) Sci Transl Med , vol.4 , Issue.155 , pp. 155ra138
    • Bagarazzi, M.L.1    Yan, J.2    Morrow, M.P.3
  • 62
    • 84898869622 scopus 로고    scopus 로고
    • Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: Safety and efficacy results of a phase i first-in-man study
    • Spanggaard I, Snoj M, Cavalcanti A, et al. Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: safety and efficacy results of a phase I first-in-man study. Hum Gene Ther Clin Dev 2013;24(3):99-107
    • (2013) Hum Gene Ther Clin Dev , vol.24 , Issue.3 , pp. 99-107
    • Spanggaard, I.1    Snoj, M.2    Cavalcanti, A.3
  • 64
    • 84877950434 scopus 로고    scopus 로고
    • In vivo DNA electrotransfer for immunotherapy of cancer and neurodegenerative diseases
    • Fioretti D, Iurescia S, Fazio VM, Rinaldi M. In vivo DNA electrotransfer for immunotherapy of cancer and neurodegenerative diseases. Curr Drug Metabol 2013;14(3):279-90
    • (2013) Curr Drug Metabol , vol.14 , Issue.3 , pp. 279-290
    • Fioretti, D.1    Iurescia, S.2    Fazio, V.M.3    Rinaldi, M.4
  • 65
    • 80052498736 scopus 로고    scopus 로고
    • Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine
    • Yan J, Corbitt N, Pankhong P, et al. Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine. Vaccine 2011; 29(41):7173-81
    • (2011) Vaccine , vol.29 , Issue.41 , pp. 7173-7181
    • Yan, J.1    Corbitt, N.2    Pankhong, P.3
  • 66
    • 78649658963 scopus 로고    scopus 로고
    • Biodistribution persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation
    • Bråve A, Gudmundsdotter L, Sandström E, et al. Biodistribution, persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation. Vaccine 2010; 28(51):8203-9
    • (2010) Vaccine , vol.28 , Issue.51 , pp. 8203-8209
    • Bråve, A.1    Gudmundsdotter, L.2    Sandström, E.3
  • 67
    • 84888046822 scopus 로고    scopus 로고
    • Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates
    • Chakrabarti BK, Feng Y, Sharma SK, et al. Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates. J Virol 2013; 87(24):13239-51
    • (2013) J Virol , vol.87 , Issue.24 , pp. 13239-13251
    • Chakrabarti, B.K.1    Feng, Y.2    Sharma, S.K.3
  • 68
    • 80052288358 scopus 로고    scopus 로고
    • Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques
    • Kulkarni V, Jalah R, Ganneru B, et al. Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques. Vaccine 2011;29(39):6742-54
    • (2011) Vaccine , vol.29 , Issue.39 , pp. 6742-6754
    • Kulkarni, V.1    Jalah, R.2    Ganneru, B.3
  • 69
    • 84898716198 scopus 로고    scopus 로고
    • DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques
    • Jalah R, Kulkarni V, Patel V, et al. DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques. PLoS One 2014;9(3):e91550
    • (2014) PLoS One , vol.9 , Issue.3 , pp. e91550
    • Jalah, R.1    Kulkarni, V.2    Patel, V.3
  • 70
    • 84884365634 scopus 로고    scopus 로고
    • Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA
    • Ferraro B, Talbott KT, Balakrishnan A, et al. Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA. Infect Immunity 2013; 81(10):3709-20
    • (2013) Infect Immunity , vol.81 , Issue.10 , pp. 3709-3720
    • Ferraro, B.1    Talbott, K.T.2    Balakrishnan, A.3
  • 71
    • 84908424138 scopus 로고    scopus 로고
    • Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine
    • Latimer B, Toporovski R, Yan J, et al. Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine. Human Vaccines Immunother 2014;10:8
    • (2014) Human Vaccines Immunother , vol.10 , pp. 8
    • Latimer, B.1    Toporovski, R.2    Yan, J.3
  • 72
    • 51549108762 scopus 로고    scopus 로고
    • Immunotherapy for HCV infection: Next steps
    • Lang K, Weiner DB. Immunotherapy for HCV infection: next steps. Expert Rev Vaccines 2008;7(7):915-23
    • (2008) Expert Rev Vaccines , vol.7 , Issue.7 , pp. 915-923
    • Lang, K.1    Weiner, D.B.2
  • 73
    • 32444449395 scopus 로고    scopus 로고
    • A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that overcomes preexisting anti-Ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques
    • Capone S, Meola A, Ercole BB, et al. A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that overcomes preexisting anti-Ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques. J Virol 2006;80(4):1688-99
    • (2006) J Virol , vol.80 , Issue.4 , pp. 1688-1699
    • Capone, S.1    Meola, A.2    Ercole, B.B.3
  • 74
    • 31844441458 scopus 로고    scopus 로고
    • Anti-HBV immune responses in rhesus macaques elicited by electroporation mediated DNA vaccination
    • Zhao Y-GG, Peng B, Deng H, et al. Anti-HBV immune responses in rhesus macaques elicited by electroporation mediated DNA vaccination. Vaccine 2006; 24(7):897-903
    • (2006) Vaccine , vol.24 , Issue.7 , pp. 897-903
    • Zhao, Y.-G.G.1    Peng, B.2    Deng, H.3
  • 75
    • 44649143183 scopus 로고    scopus 로고
    • Electroporation-mediated HBV DNA vaccination in primate models
    • Zhao Y-GG, Xu Y. Electroporation-mediated HBV DNA vaccination in primate models. Methods Mol Biol (Clifton, N.J.) 2008;423: 487-95
    • (2008) Methods Mol Biol (Clifton, N.J. , vol.423 , pp. 487-495
    • Zhao, Y.-G.G.1    Xu, Y.2
  • 76
    • 84907095606 scopus 로고    scopus 로고
    • An optimized synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of clostridium difficile induces protective antibody responses in vivo
    • Baliban SM, Michael A, Shammassian B, et al. An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of clostridium difficile induces protective antibody responses in vivo. Infect Immunity 2014;82(10):4080-91
    • (2014) Infect Immunity , vol.82 , Issue.10 , pp. 4080-4091
    • Baliban, S.M.1    Michael, A.2    Shammassian, B.3
  • 77
    • 66149110932 scopus 로고    scopus 로고
    • Electroporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus
    • Laddy DJ, Yan J, Khan AS, et al. Electroporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus. J Virol 2009;83(9):4624-30
    • (2009) J Virol , vol.83 , Issue.9 , pp. 4624-4630
    • Laddy, D.J.1    Yan, J.2    Khan, A.S.3
  • 78
    • 84868146325 scopus 로고    scopus 로고
    • A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge
    • Grant-Klein RJ, Deusen NM, Badger CV, et al. A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge. Human Vaccines Immunother 2012;8(11):1703-6
    • (2012) Human Vaccines Immunother , vol.8 , Issue.11 , pp. 1703-1706
    • Grant-Klein, R.J.1    Deusen, N.M.2    Badger, C.V.3
  • 80
    • 79956061128 scopus 로고    scopus 로고
    • In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers
    • Vasan S, Hurley A, Schlesinger SJ, et al. In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers. PLoS One 2011;6(5):e19252
    • (2011) PLoS One , vol.6 , Issue.5 , pp. e19252
    • Vasan, S.1    Hurley, A.2    Schlesinger, S.J.3
  • 82
    • 84855361060 scopus 로고    scopus 로고
    • Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy HIV-1 uninfected adults
    • Kalams SA, Parker S, Jin X, et al. Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adults. PLoS One 2012; 7(1):e29231
    • (2012) PLoS One , vol.7 , Issue.1 , pp. e29231
    • Kalams, S.A.1    Parker, S.2    Jin, X.3
  • 83
    • 84879571436 scopus 로고    scopus 로고
    • Therapeutic and prophylactic DNA vaccines for HIV-1
    • Ramirez LA, Arango T, Boyer J. Therapeutic and prophylactic DNA vaccines for HIV-1. Expert Opin Biol Ther 2013; 13(4):563-73
    • (2013) Expert Opin Biol Ther , vol.13 , Issue.4 , pp. 563-573
    • Ramirez, L.A.1    Arango, T.2    Boyer, J.3
  • 84
    • 84857189927 scopus 로고    scopus 로고
    • A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome
    • Boudreau EF, Josleyn M, Ullman D, et al. A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome. Vaccine 2012;30(11):1951-8
    • (2012) Vaccine , vol.30 , Issue.11 , pp. 1951-1958
    • Boudreau, E.F.1    Josleyn, M.2    Ullman, D.3
  • 85
    • 84897494777 scopus 로고    scopus 로고
    • A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation
    • Hooper JW, Moon JE, Paolino KM, et al. A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation. Clin Microbiol Infect 2014; 20(Suppl 5):110-17
    • (2014) Clin Microbiol Infect , vol.20 , pp. 110-117
    • Hooper, J.W.1    Moon, J.E.2    Paolino, K.M.3
  • 86
    • 84902276307 scopus 로고    scopus 로고
    • DNA vaccines for HFRS: Laboratory and clinical studies
    • Schmaljohn CS, Spik KW, Hooper JW. DNA vaccines for HFRS: laboratory and clinical studies. Virus Res 2014;187:91-6
    • (2014) Virus Res , vol.187 , pp. 91-96
    • Schmaljohn, C.S.1    Spik, K.W.2    Hooper, J.W.3
  • 87
    • 84883741031 scopus 로고    scopus 로고
    • Therapeutic DNA vaccination using in vivo electroporation followed by standard of care therapy in patients with genotype 1 chronic hepatitis C
    • Weiland O, Ahle-n G, Diepolder H, et al. Therapeutic DNA vaccination using in vivo electroporation followed by standard of care therapy in patients with genotype 1 chronic hepatitis C. Mol Ther J Am Soc Gene Ther 2013;21(9):1796-805
    • (2013) Mol Ther J Am Soc Gene Ther , vol.21 , Issue.9 , pp. 1796-1805
    • Weiland, O.1    Ahle-N, G.2    Diepolder, H.3
  • 88
    • 44949195901 scopus 로고    scopus 로고
    • Results of the first phase I/II clinical vaccination trial with direct injection of mRNA
    • Hagerstown, Md. 1997
    • Weide B, Carralot J-PP, Reese A, et al. Results of the first phase I/II clinical vaccination trial with direct injection of mRNA. J Immunother (Hagerstown, Md. 1997) 2008;31(2):180-8
    • (2008) J Immunother , vol.31 , Issue.2 , pp. 180-188
    • Weide, B.1    Carralot, J.-P.P.2    Reese, A.3
  • 89
    • 67651152679 scopus 로고    scopus 로고
    • Direct injection of protamine-protected mRNA: Results of a phase 1/2 vaccination trial in metastatic melanoma patients
    • Hagerstown, M.d. 1997
    • Weide B, Pascolo S, Scheel B, et al. Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. J Immunother (Hagerstown, Md. 1997) 2009;32(5):498-507
    • (2009) J Immunother , vol.32 , Issue.5 , pp. 498-507
    • Weide, B.1    Pascolo, S.2    Scheel, B.3
  • 90
    • 79955630363 scopus 로고    scopus 로고
    • Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients
    • Rittig SM, Haentschel M, Weimer KJ, et al. Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients. Mol Ther J Am Soc Gene Ther 2011;19(5):990-9
    • (2011) Mol Ther J Am Soc Gene Ther , vol.19 , Issue.5 , pp. 990-999
    • Rittig, S.M.1    Haentschel, M.2    Weimer, K.J.3
  • 91
    • 84865994357 scopus 로고    scopus 로고
    • Nonviral delivery of self-Amplifying RNA vaccines
    • Geall AJ, Verma A, Otten GR, et al. Nonviral delivery of self-Amplifying RNA vaccines. Proc Natl Acad Sci USA 2012;109(36):14604-9
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.36 , pp. 14604-14609
    • Geall, A.J.1    Verma, A.2    Otten, G.R.3
  • 92
    • 84882259948 scopus 로고    scopus 로고
    • RNA: The new revolution in nucleic acid vaccines
    • Geall AJ, Mandl CW, Ulmer JB. RNA: the new revolution in nucleic acid vaccines. Semin Immunol 2013;25(2):152-9
    • (2013) Semin Immunol , vol.25 , Issue.2 , pp. 152-159
    • Geall, A.J.1    Mandl, C.W.2    Ulmer, J.B.3
  • 93
    • 84927176976 scopus 로고    scopus 로고
    • A cationic nanoemulsion for the delivery of next-generation rna vaccines
    • Epub ahead of print
    • Brito LA, Chan M, Shaw CA, et al. A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines. Mol Ther J Am Soc Gene Ther 2014. [Epub ahead of print]
    • (2014) Mol Ther J Am Soc Gene Ther.
    • Brito, L.A.1    Chan, M.2    Shaw, C.A.3
  • 94
    • 84898604804 scopus 로고    scopus 로고
    • Development of nucleic acid vaccines: Use of self-Amplifying RNA in lipid nanoparticles
    • Rodríguez-Gasco-n A, Pozo-Rodríguez A, Solinís MA ' . Development of nucleic acid vaccines: use of self-Amplifying RNA in lipid nanoparticles. Int J Nanomed 2014;9: 1833-43
    • (2014) Int J Nanomed , vol.9 , pp. 1833-1843
    • Rodríguez-Gasco-N, A.1    Pozo-Rodríguez, A.2    Solinís, M.A.3
  • 95
    • 84901249588 scopus 로고    scopus 로고
    • Nucleic acid vaccines: Prospects for non-viral delivery of mRNA vaccines
    • Deering RP, Kommareddy S, Ulmer JB, et al. Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines. Expert Opin Drug Deliv 2014;11(6):885-99
    • (2014) Expert Opin Drug Deliv , vol.11 , Issue.6 , pp. 885-899
    • Deering, R.P.1    Kommareddy, S.2    Ulmer, J.B.3
  • 97
    • 84868365382 scopus 로고    scopus 로고
    • Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation
    • Broderick KE, Chan A, Lin F, et al. Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation. Mol Ther Nucleic Acids 2012;1:e11
    • (2012) Mol Ther Nucleic Acids , vol.1 , pp. e11
    • Broderick, K.E.1    Chan, A.2    Lin, F.3
  • 99
    • 34247141017 scopus 로고    scopus 로고
    • In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery
    • Golzio M, Mazzolini L, Ledoux A, et al. In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery. Gene Ther 2007;14(9): 752-9
    • (2007) Gene Ther , vol.14 , Issue.9 , pp. 752-759
    • Golzio, M.1    Mazzolini, L.2    Ledoux, A.3
  • 100
    • 44649114578 scopus 로고    scopus 로고
    • Optical in vivo imaging of electrically mediated delivery of siRNA into muscle for gene function analysis
    • Golzio M, Teissie- J. Optical in vivo imaging of electrically mediated delivery of siRNA into muscle for gene function analysis. Methods Mol Biol (Clifton, N.J.) 2008;423:279-87
    • (2008) Methods Mol Biol (Clifton, N.J. , vol.423 , pp. 279-287
    • Golzio, M.1    Teissie-, J.2
  • 101
    • 84555196416 scopus 로고    scopus 로고
    • Shrna-mediated gene knockdown in skeletal muscle
    • Clifton, N.J.
    • Golzio M, Escoffre J-MM, Teissie- J. shRNA-mediated gene knockdown in skeletal muscle. Methods Mol Biol (Clifton, N.J.) 2012;798:491-501
    • (2012) Methods Mol Biol. , vol.798 , pp. 491-501
    • Golzio, M.1    J-Mm, E.2    Teissie-, J.3
  • 102
    • 84877938842 scopus 로고    scopus 로고
    • Nucleic acids electro-Transfer: From bench to bedside
    • Chabot S, Rosazza C, Golzio M, et al. Nucleic acids electro-Transfer: from bench to bedside. Curr Drug Metab 2013;14(3):300-8
    • (2013) Curr Drug Metab , vol.14 , Issue.3 , pp. 300-308
    • Chabot, S.1    Rosazza, C.2    Golzio, M.3
  • 103
    • 84922329276 scopus 로고    scopus 로고
    • Targeted electro-delivery of oligonucleotides for RNA interference: SiRNA and antimiR
    • Epub ahead of print
    • Chabot S, Teissie- J, Golzio M. Targeted electro-delivery of oligonucleotides for RNA interference: siRNA and antimiR. Advanced Drug Deliv Rev 2014; Epub ahead of print
    • (2014) Advanced Drug Deliv Rev.
    • Chabot, S.1    Teissie-, J.2    Golzio, M.3
  • 105
    • 84901269661 scopus 로고    scopus 로고
    • Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ
    • Cu Y, Broderick K, Banerjee K, et al. Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ. Vaccines 2013;1(3):367383
    • (2013) Vaccines , vol.1 , Issue.3 , pp. 367383
    • Cu, Y.1    Broderick, K.2    Banerjee, K.3
  • 106
    • 84921357729 scopus 로고    scopus 로고
    • Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients
    • Kim TJ, Jin HT, Hur SY, et al. Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients. Nat Commun 2014;5:5317
    • (2014) Nat Commun , vol.5 , pp. 5317
    • Kim, T.J.1    Jin, H.T.2    Hur, S.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.