Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses

Human Vaccines and Immunotherapeutics

Volumn 9, Issue 10, 2013, Pages 2041-2048

  Kichaev, Gleb ^a   Mendoza, Janess M ^a   Amante, Dinah ^a   Smith, Trevor R F ^a   McCoy, Jay R ^a   Sardesai, Niranjan Y ^a   Broderick, Kate E ^a  

^a Inovio Pharmaceuticals Inc   (United States)

Author keywords

Direct mucosal; DNA vaccine; Electroporation; Intradermal

Indexed keywords

DNA VACCINE; IMMUNOGLOBULIN G; VIRUS NUCLEOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CHEEK MUCOSA; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY DEVICE; ELECTROPORATION; EPITHELIUM; FEMALE; GUINEA PIG; HUMORAL IMMUNITY; INFLUENZA VIRUS A H1N1; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; REPORTER GENE; TISSUE INJURY; VIRAL GENE DELIVERY SYSTEM;

DIRECT MUCOSAL; DNA VACCINE; ELECTROPORATION; INTRADERMAL;

ADMINISTRATION, MUCOSAL; ANIMALS; ANTIBODIES, VIRAL; ELECTROPORATION; FEMALE; GUINEA PIGS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFLUENZA VACCINES; MICE, INBRED BALB C; MOUTH MUCOSA; VACCINATION; VACCINES, DNA; VAGINA;

EID: 84885135914     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.25272     Document Type: Article

References (38)

1. Belyakov IM, Ahlers JD. Mucosal immunity and HIV-1 infection: applications for mucosal AIDS vaccine development. Curr Top Microbiol Immunol 2012;354:157-79; PMID:21203884; http://dx.doi.org/10.1007/82-2010-119
2. Liu MA. DNA vaccines: an historical perspective and view to the future. Immunol Rev 2011;239:62-84; PMID:21198665; http://dx.doi.org/10.1111/j.1600- 065X.2010.00980.x
3. Weiner DB. DNA vaccines: crossing a line in the sand. Introduction to special issue. Vaccine 2008;26:5073-4; PMID:18652867; http://dx.doi.org/10.1016/ j.vaccine.2008.07.024
4. Donnelly JJ, Ulmer JB, Shiver JW, Liu MA. DNA vaccines. Annu Rev Immunol 1997;15:617-48; PMID:9143702; http://dx.doi.org/10.1146/annurev. immunol. 15.1.617
5. Sardesai NY, Weiner DB. Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 2011;23:421-9; PMID:21530212; http://dx.doi.org/10.1016/j.coi.2011.03.008
6. Sugar IP, Neumann E. Stochastic model for electric field-induced membrane pores. Electroporation. Biophys Chem 1984;19:211-25; PMID:6722274; http://dx.doi.org/1 0.1016/0301-4622 (84) 87003-9
7. Sugar IP, Förster W, Neumann E. Model of cell electrofusion. Membrane electroporation, pore coalescence and percolation. Biophys Chem 1987;26:321-35; PMID:3607233; http://dx.doi.org/10.1016/0301-4622 (87) 80033-9
8. Wolf H, Rols MP, Boldt E, Neumann E, Teissié J. Control by pulse parameters of electric field-mediated gene transfer in mammalian cells. Biophys J 1994;66:524-31; PMID:8161705; http://dx.doi.org/10.1016/S0006-3495 (94) 80805-7
9. Chiarella P, Massi E, De Robertis M, Sibilio A, Parrella P, Fazio VM, et al. Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA vaccine administration. Expert Opin Biol Ther 2008;8:1645-57; PMID: 18847301; http://dx.doi.org/10. 1517/14712598.8.11.1645
10. Ahlen G, Soderholm J, Tjelle T, Kjeken R, Frelin L, Hoglund U, et al. In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ T cells. J Immunol 2007;179:4741-53; PMID:17878373
11. Widera G, Austin M, Rabussay D, Goldbeck C, Barnett SW, Chen M, et al. Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 2000;164:4635-40; PMID:10779767
12. Bagarazzi ML, Yan J, Morrow MP, Shen X, Parker RL, Lee JC, et al. Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med 2012;4:ra138; PMID:23052295; http://dx.doi.org/10.1126/scitranslmed. 3004414
13. Zucchelli S, Capone S, Fattori E, Folgori A, Di Marco A, Casimiro D, et al. Enhancing B-and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J Virol 2000;74:11598-607; PMID:11090158; http://dx.doi.org/10.1128/JVI.74.24.11598-11607.2000
14. Van Drunen Littel-Van Den Hurk S, Lawman Z, Wilson D, Luxembourg A, Ellefsen B, Van Den Hurk JV, et al. Electroporation enhances immune responses and protection induced by a bovine viral diarrhea virus DNA vaccine in newborn calves with maternal antibodies. Vaccine 2010;28:6445-54; PMID:20670907; http://dx.doi.org/10.1016/j.vaccine.2010.07.045
15. Kanazawa T, Takashima Y, Hirayama S, Okada H. Effects of menstrual cycle on gene transfection through mouse vagina for DNA vaccine. Int J Pharm 2008;360:164-70; PMID: 18573624; http://dx.doi.org/10.1016/j.ijpharm.2008.04.038
16. Ban EM, Van Ginkel FW, Simecka JW, Kiyono H, Robinson HL, McGhee JR. Mucosal immunization with DNA encoding influenza hemagglutinin. Vaccine 1997;15:811-3; PMID:9234521; http://dx.doi.org/10.1016/S0264-410X (96) 00263-0
17. Broderick KE, Shen X, Soderholm J, Lin F, McCoy J, Khan AS, et al. Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device. Gene Ther 2011;18:258-65; PMID:20962869; http://dx.doi.org/10.1038/gt.2010.137
18. Heller R, Cruz Y, Heller LC, Gilbert RA, Jaroszeski MJ. Electrically mediated delivery of plasmid DNA to the skin, using a multielectrode array. Hum Gene Ther 2010;21:357-62; PMID:19839722; http://dx.doi.org/10.1089/hum.2009.065
19. Donate A, Coppola D, Cruz Y, Heller R. Evaluation of a novel non-penetrating electrode for use in DNA vaccination. PLoS One 2011;6:e19181; PMID:21559474; http://dx.doi.org/10.1371/journal. pone.0019181
20. Zhang L, Li L, Hoffmann GA, Hoffman RM. Depthtargeted efficient gene delivery and expression in the skin by pulsed electric fields: an approach to gene therapy of skin aging and other diseases. Biochem Biophys Res Commun 1996;220:633-6; PMID:8607816; http://dx.doi.org/10.1006/b brc.1996.0455
21. Heller LC, Jaroszeski MJ, Coppola D, McCray AN, Hickey J, Heller R. Optimization of cutaneous electrically mediated plasmid DNA delivery using novel electrode. Gene Ther 2007;14:275-80; PMID: 16988718; http://dx.doi.org/10.1038/ sj.gt.3302867
22. Zhang L, Nolan E, Kreitschitz S, Rabussay DP. Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation. Biochim Biophys Acta 2002;1572:1-9; PMID:12204326; http://dx.doi.org/10.1016/S0304-4165 (02) 00270-2
23. Diehl MC, Lee JC, Daniels SE, Tebas P, Khan A, Giffear M, et al. Tolerability of Intramuscular and Intradermal Delivery by CELLECTRA® Adaptive Constant Current Electroporation Device in Healthy Volunteers. Hum Vaccin and Immunother 2013.
24. Tjelle TE, Salte R, Mathiesen I, Kjeken R. A novel electroporation device for gene delivery in large animals and humans. Vaccine 2006;24:4667-70; PMID:16162367; http://dx.doi.org/10.1016/j. vaccine.2005.08.068
25. Patel V, Valentin A, Kulkarni V, Rosati M, Bergamaschi C, Jalah R, et al. Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization. Vaccine 2010;28:4827-36; PMID:20451642; http://dx.doi.org/10.1016/j.vaccine.2010.04.064
26. Shen X, Soderholm J, Lin F, Kobinger G, Bello A, Gregg DA, et al. Influenza A vaccines using linear expression cassettes delivered via electroporation afford full protection against challenge in a mouse model. Vaccine 2012;30:6946-54; PMID:22406460; http://dx.doi.org/10.1016/j.vaccine. 2012.02.071
27. Locher CP, Putnam D, Langer R, Witt SA, Ashlock BM, Levy JA. Enhancement of a human immunodeficiency virus env DNA vaccine using a novel polycationic nanoparticle formulation. Immunol Lett 2003;90:67-70; PMID:14687705; http://dx.doi.org/10.1016/j.imlet.2003.02.001
28. Eriksson K, Ahlfors E, George-Chandy A, Kaiserlian D, Czerkinsky C. Antigen presentation in the murine oral epithelium. Immunology 1996;88:147-52; PMID:8707342; http://dx.doi.org/10.1046/j.1365-2567.1996.d01-647.x
29. Fagarasan S, Honjo T. Intestinal IgA synthesis: regulation of front-line body defences. Nat Rev Immunol 2003;3:63-72; PMID:12511876; http://dx.doi.org/ 10.1038/nri982
30. Alfsen A, Iniguez P, Bouguyon E, Bomsel M. Secretory IgA specific for a conserved epitope on gp41 envelope glycoprotein inhibits epithelial transcytosis of HIV-1. J Immunol 2001;166:6257-65; PMID:11342649
31. Hocini H, Bomsel M. Infectious human immunodeficiency virus can rapidly penetrate a tight human epithelial barrier by transcytosis in a process impaired by mucosal immunoglobulins. J Infect Dis 1999;179 t(Suppl 3):S448-53; PMID:10099117; http://dx.doi.org/10.1086/314802
32. Clerici M, Barassi C, Devito C, Pastori C, Piconi S, Trabattoni D, et al. Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41. AIDS 2002;16:1731-41; PMID: 12218383; http://dx.doi.org/10.1097/00002030-200209060-00004
33. Wang B, Dang K, Agadjanyan MG, Srikantan V, Li F, Ugen KE, et al. Mucosal immunization with a DNA vaccine induces immune responses against HIV-1 at a mucosal site. Vaccine 1997;15:821-5; PMID:9234524; http://dx.doi.org/10.1016/ S0264-410X (96) 0025 9-9
34. Fynan EF, Robinson HL, Webster RG. Use of DNA encoding influenza hemagglutinin as an avian influenza vaccine. DNA Cell Biol 1993;12:785-9; PMID:8216849; http://dx.doi.org/10.1089/dna.1993.12.785
35. Liu J, Kjeken R, Mathiesen I, Barouch DH. Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation. J Virol 2008;82:5643-9; PMID:18353952; http://dx.doi.org/10. 1128/JVI.02564-07
36. Kadish AS, Timmins P, Wang Y, Ho GY, Burk RD, Ketz J, et al.; Albert Einstein Cervix Dysplasia Clinical Consortium. Regression of cervical intraepithelial neoplasia and loss of human papillomavirus (HPV) infection is associated with cell-mediated immune responses to an HPV type 16 E7 peptide. Cancer Epidemiol Biomarkers Prev 2002;11:483-8; PMID: 12010863
37. Riddell SR, Gilbert MJ, Greenberg PD. CD8+ cytotoxic T cell therapy of cytomegalovirus and HIV infection. Curr Opin Immunol 1993;5:484-91; PMID:8216922; http://dx.doi.org/10.1016/0952-7915 (93) 90027-P
38. Lin F, Shen X, McCoy JR, Mendoza JM, Yan J, Kemmerrer SV, et al. A novel prototype device for electroporation-enhanced DNA vaccine delivery simultaneously to both skin and muscle. Vaccine 2011;29:6771-80; PMID:21199706; http://dx.doi.org/10.1016/j.vaccine. 2010.12.057