Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 3, 2015, Pages 899-904

  Lia, Qiang ^a   Wanga, Ping ^a   Ye, Keqiang ^b   Caia, Hua ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardioprotection; DCC; Netrin 1 nitric oxide; SIAH

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DELETED IN COLORECTAL CANCER PROTEIN; MEMBRANE RECEPTOR; NETRIN 1; NITRIC OXIDE; PROTEIN; SEVEN IN ABSENTIA HOMOLOG 1 PROTEIN; SEVEN IN ABSENTIA HOMOLOG 2 PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DCC PROTEIN, MOUSE; NERVE GROWTH FACTOR; NETRIN-1; NUCLEAR PROTEIN; SEVEN IN ABSENTIA PROTEINS; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; ECHOCARDIOGRAPHY; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HEART EJECTION FRACTION; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPERFUSION INJURY; RNA INTERFERENCE; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; GENETICS; HEART; HEK293 CELL LINE; HUMAN; MALE; MYOCARDIAL INFARCTION; PHYSIOLOGY;

MUS;

ANIMALS; HEART; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; NERVE GROWTH FACTORS; NITRIC OXIDE; NUCLEAR PROTEINS; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84921364521     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1420695112     Document Type: Article

References (28)

1. Fearon ER, et al. (1990) Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247(4938):49-56.
2. Keino-Masu K, et al. (1996) Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87(2):175-185.
3. Liu G, et al. (2004) Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci 7(11):1222-1232.
4. Mehlen P, et al. (1998) The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395(6704):801-804.
5. Mazelin L, et al. (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431(7004):80-84.
6. Nguyen A, Cai H (2006) Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci USA 103(17):6530-6535.
7. Park KW, et al. (2004) The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA 101(46):16210-16215.
8. Zhang J, Cai H (2010) Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism. J Mol Cell Cardiol 48(6):1060-1070.
9. Bouhidel JO, et al. (2014) Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. Biochim Biophys Acta, 10.1016/j.bbadis.2014.06.005.
10. Bouhidel JO, Wang P, Li Q, Cai H (2014) Pharmacological postconditioning treatment of myocardial infarction with netrin-1. Front Biosci (Landmark Ed) 19(3):566-570.
11. Deshaies RJ, Joazeiro CA (2009) RING domain E3 ubiquitin ligases. Annu Rev Biochem 78:399-434.
12. Powell SR, Herrmann J, Lerman A, Patterson C, Wang X (2012) The ubiquitin-proteasome system and cardiovascular disease. Prog Mol Biol Transl Sci 109(chap 9): 295-346.
13. Narmoneva DA, Vukmirovic R, Davis ME, Kamm RD, Lee RT (2004) Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration. Circulation 110(8):962-968.
14. Kuramochi Y, et al. (2004) Cardiac endothelial cells regulate reactive oxygen speciesinduced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem 279(49):51141-51147.
15. Hu G, et al. (1997) Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev 11(20):2701-2714.
16. Hu G, Fearon ER (1999) Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol Cell Biol 19(1):724-732.
17. Hu G, et al. (1997) Characterization of human homologs of the Drosophila seven in absentia (sina) gene. Genomics 46(1):103-111.
18. Schmidt RL, et al. (2007) Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. Cancer Res 67(24):11798-11810.
19. Lee SH, et al. (2011) Novel tumor suppressive function of Smad4 in serum starvationinduced cell death through PAK1-PUMA pathway. Cell Death Dis 2(12):e235.
20. Bhanot M, Smith S (2012) TIN2 stability is regulated by the E3 ligase Siah2. Mol Cell Biol 32(2):376-384.
21. Youn JY, Gao L, Cai H (2012) The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes. Diabetologia 55(7):2069-2079.
22. Kuo TY, Hong CJ, Hsueh YP (2009) Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth. Mol Cell Neurosci 42(3):195-207.
23. Welchman RL, Gordon C, Mayer RJ (2005) Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol 6(8):599-609.
24. Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction. Physiol Rev 82(2):373-428.
25. Kuratomi G, et al. (2005) NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factorbeta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J 386(Pt 3):461-470.
26. House CM, et al. (2003) A binding motif for Siah ubiquitin ligase. Proc Natl Acad Sci USA 100(6):3101-3106.
27. Moynagh PN (2014) The roles of Pellino E3 ubiquitin ligases in immunity. Nat Rev Immunol 14(2):122-131.
28. Siu KL, Lotz C, Ping P, Cai H (2015) Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS. J Mol Cell Cardiol 78C:174-185.