TIN2 stability is regulated by the E3 ligase Siah2

Molecular and Cellular Biology

Volumn 32, Issue 2, 2012, Pages 376-384

  Bhanot, Monica ^a   Smith, Susan ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGASE; PROTEASOME; PROTEIN; PROTEIN TIN2; SIAH2 E3 LIGASE; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL CYCLE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN STABILITY; UBIQUITINATION;

BINDING SITES; GENE DELETION; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STABILITY; TELOMERE; TELOMERE-BINDING PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UP-REGULATION;

EID: 84863011409     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.06227-11     Document Type: Article

References (56)

1. Abreu E, et al. 2010. TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol. Cell. Biol. 30:2971-2982.
2. Ancelin K, et al. 2002. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol. Cell. Biol. 22: 3474-3487.
3. Atanassov BS, et al. 2009. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol. Cell 35:352-364.
4. Bartel PL, Chien C, Sternglanz R, Fields S. 1993. Using the two-hybrid system to detect protein-protein interaction, p 153-179. In D. A. Harley (ed), Cellular interactions in development: a practical approach. IRL Press, Oxford, United Kingdom.
5. Baumann P, Cech TR. 2001. Pot1, the putative telomere end-binding protein in ssion yeast and humans. Science 292:1171-1175.
6. Bessler M, Wilson DB, Mason PJ. 2010. Dyskeratosis congenita. FEBS Lett. 584:3831-3838.
7. Bianchi A, Smith S, Chong L, Elias P, de Lange T. 1997. TRF1 is a dimer and bends telomeric DNA. EMBO J. 16:1785-1794.
8. Bilaud T, et al. 1997. Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 17:236-239.
9. Broccoli D, Smogorzewska A, Chong L, de Lange T. 1997. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 17:231-235.
10. Canudas S, et al. 2011. A role for heterochromatin protein 1γ at human telomeres. Genes Dev. 25:1807-1819.
11. Canudas S, et al. 2007. Protein requirements for sister telomere associa-tion in human cells. EMBO J. 26:4867-4878.
12. Cardozo T, Pagano M. 2004. The SCF ubiquitin ligase: insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 5:739-751.
13. Chang W, Dynek JN, Smith S. 2003. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev. 17: 1328-1333.
14. Chen Y, et al. 2008. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319:1092-1096.
15. Chong L, et al. 1995. A human telomeric protein. Science 270:1663-1667.
16. Cook BD, Dynek JN, Chang W, Shostak G, Smith S. 2002. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telo-meres. Mol. Cell. Biol. 22:332-342.
17. Cristofari G, Lingner J. 2006. Telomere length homeostasis requires that telomerase levels are limiting. EMBO J. 25:565-574.
18. Deshaies RJ, Joazeiro CA. 2009. RING domain E3 ubiquitin ligases. Annu. Rev. Biochem. 78:399-434.
19. Fairall L, Chapman L, Moss H, de Lange T, Rhodes D. 2001. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol. Cell 8:351-361.
20. Fujita K, et al. 2010. Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat. Cell Biol. 12: 1205-1212.
21. Her YR, Chung IK. 2009. Ubiquitin ligase RLIM modulates telomere length homeostasis through a proteolysis of TRF1. J. Biol. Chem. 284: 8557-8566.
22. Hershko A, Ciechanover A. 1998. The ubiquitin system. Annu. Rev. Biochem. 67:425-479.
23. Hollenberg SM, Sternglanz R, Cheng PF, Weintraub H. 1995. Identi-cation of a new family of tissue-specic basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15:3813-3822.
24. Houghtaling BR, Cuttonaro L, Chang W, Smith S. 2004. A dynamic molecular link between the telomere length regulator TRF1 and the chro-mosome end protector TRF2. Curr. Biol. 14:1621-1631.
25. House CM, et al. 2003. A binding motif for Siah ubiquitin ligase. Proc. Natl. Acad. Sci. U. S. A. 100:3101-3106.
26. House CM, et al. 2006. Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure 14:695-701.
27. Hu G, Fearon ER. 1999. Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. Mol. Cell. Biol. 19:724-732.
28. Hu G, et al. 1997. Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev. 11:2701-2714.
29. Johnsen SA, et al. 2009. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res. 69: 128-136.
30. Kim MK, et al. 2008. Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. J. Biol. Chem. 283:14144-14152.
31. Kim SH, et al. 2004. TIN2 mediates functions of TRF2 at human telo-meres. J. Biol. Chem. 279:43799-43804.
32. Kim SH, Kaminker P, Campisi J. 1999. TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23:405-412.
33. Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ. 2006. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J. Biol. Chem. 281:759-768.
34. Li B, Oestreich S, de Lange T. 2000. Identication of human Rap1: implications for telomere evolution. Cell 101:471-483.
35. Lillard-Wetherell K, et al. 2004. Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2. Hum. Mol. Genet. 13:1919-1932.
36. Lin DI, et al. 2006. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol. Cell 24:355-366.
37. Liu D, O'ConnorMS, Qin J, Songyang Z. 2004. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279:51338-51342.
38. Liu D, et al. 2004. PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol. 6:673-680.
39. Loayza D, de Lange T. 2003. POT1 as a terminal transducer of TRF1 telomere length control. Nature 423:1013-1018.
40. Nakayama K, Qi J, Ronai Z. 2009. The ubiquitin ligase Siah2 and the hypoxia response. Mol. Cancer Res. 7:443-451.
41. Palm W, de Lange T. 2008. How shelterin protects mammalian telo-meres. Annu. Rev. Genet. 42:301-334.
42. Savage SA, et al. 2008. TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am. J. Hum. Genet. 82:501-509.
43. Sfeir A, et al. 2009. Mammalian telomeres resemble fragile sites and require TRF1 for efcient replication. Cell 138:90-103.
44. Smith S, de Lange T. 2000. Tankyrase promotes telomere elongation in human cells. Curr. Biol. 10:1299-1302.
45. Smith S, Giriat I, Schmitt A, de Lange T. 1998. Tankyrase, a poly(ADP-ribose) polyemrase at human telomeres. Science 282:1484-1487.
46. Soohoo CY, et al. 2011. Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation. J. Biol. Chem. 286:3894-3906.
47. Treier M, Staszewski LM, Bohmann D. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78: 787-798.
48. van Steensel B, de Lange T. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385:740-743.
49. van Steensel B, Smogorzewska A, de Lange T. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
50. Walne AJ, Vulliamy T, Beswick R, Kirwan M, Dokal I. 2008. TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bonemarrow failure syndromes. Blood 112:3594-3600.
51. Winter M, et al. 2008. Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATMand ATR.Nat. Cell Biol. 10:812-824.
52. Ye JZ, de Lange T. 2004. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36:618-623.
53. Ye JZ, et al. 2004. TIN2 binds TRF1 and TRF2 simultaneously and stabi-lizes the TRF2 complex on telomeres. J. Biol. Chem. 279:47264-47271.
54. Ye JZ, et al. 2004. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev. 18: 1649-1654.
55. Zeng Z, et al. 2010. Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev. Cell 18:214-225.
56. Zhou XZ, Lu KP. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107:347-359.