Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable Haemophilus influenzae-exacerbated neutrophilia in mice

Journal of Immunology

Volumn 193, Issue 6, 2014, Pages 3134-3145

  Nikota, Jake K ^a   Shen, Pamela ^a   Morissette, Mathieu C ^b   Fernandes, Kimberly ^b   Roos, Abraham ^b   Chu, Derek K ^a   Barra, Nicole G ^a   Iwakura, Yoichiro ^c   Kolbeck, Roland ^d   Humbles, Alison A ^d   Stampfli, Martin R ^b,e  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF TOKYO   (Japan)

^d MEDIMMUNE   (United States)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; CIGARETTE SMOKE; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; CXCL1 PROTEIN, MOUSE; CXCL5 PROTEIN, MOUSE; MESSENGER RNA; SMOKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; EXPOSURE; FEMALE; GENE EXPRESSION; HAEMOPHILUS INFECTION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG ALVEOLUS MACROPHAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHILIA; NONHUMAN; NONTYPEABLE HAEMOPHILUS INFLUENZAE INFECTION; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYTOLOGY; GENETICS; HAEMOPHILUS INFLUENZAE; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; LEUKOCYTE COUNT; LUNG; LUNG LAVAGE; MICROBIOLOGY; NEUTROPHIL; PATHOLOGY; RESPIRATORY TRACT MUCOSA; SMOKE; TOBACCO;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CHEMOKINE CXCL1; CHEMOKINE CXCL5; FEMALE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; INFLAMMATION; INTERLEUKIN-1ALPHA; LEUKOCYTE COUNT; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, INTERLEUKIN-8B; RESPIRATORY MUCOSA; RNA, MESSENGER; SMOKE; TOBACCO;

EID: 84921340688     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302412     Document Type: Article

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