Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS-Ca2+-JNK mitochondrial pathways

Biochemical and Biophysical Research Communications

Volumn 456, Issue 4, 2015, Pages 926-932

  Zhang, Yuanyuan ^a   Han, Lirong ^a   Qi, Wentao ^b   Cheng, Dai ^a   Ma, Xiaolei ^a   Hou, Lihua ^a   Cao, Xiaohong ^a   Wang, Chunling ^a  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Academy of State Administration of Grain   (China)

Author keywords

Apoptosis; Ca2+; Eicosapentaenoic acid; Mitochondrial; ROS

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; CASPASE 3; CASPASE 9; CYTOCHROME C; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ICOSAPENTAENOIC ACID; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; CALCIUM; CARRIER PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; HEPG2 CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; CELL SHAPE; CELL SURVIVAL; DRUG EFFECTS; INTRACELLULAR SPACE; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION;

APOPTOSIS; CALCIUM; CASPASE 3; CASPASE 9; CELL SHAPE; CELL SURVIVAL; CYTOCHROMES C; CYTOPLASM; EICOSAPENTAENOIC ACID; HEP G2 CELLS; HUMANS; INTRACELLULAR SPACE; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 84921288137     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.12.036     Document Type: Article

References (34)

1. B.E.S. Hashem, K.L. Rudolph, Hepatocellular carcinoma: epidemiology and molecular carcinogenesis, J. Gastroenterol. 132 (2007) 2557-2576.
2. J. Whang Peng, A.L. Cheng, C. Hsu, C.M. Chen, Clinical development and future direction for the treatment of hepatocellular carcinoma, J. Exp. Clin. Med. 2 (2010) 93-103.
3. C. Galli, R. Butrum, Dietary omega 3 fatty acids and cancer: an overview, World Rev. Nutr. Diet 66 (1991) 446-461.
4. Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima, et al., Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocytespecific Pten-deficient mice, J. Hepatol. 50 (2009) 562-571.
5. Y.A. Carpentier, L. Portois, W.J. Malaisse, N-3 fatty acids and the metabolic syndrome, Am. J. Clin. Nutr. 83 (2006) 1499S-1504S.
6. G. Schmitz, J. Ecker, The opposing effects of n-3 and n-6 fatty acids, Prog. Lipid Res. 47 (2008) 147-155.
7. H. Chamras, A. Ardashian, D. Heber, J.A. Glaspy, Fatty acid modulation of MCF-7 human breast cancer cell proliferation, apoptosis and differentiation, J. Nutr. Biochem. 13 (2002) 711-717.
8. M. Murata, H. Kaji, K. Iida, Y. Okumura, K. Chihara, Dual action of eicosapentaenoic acid in hepatoma cells, J. Biol. Chem. 33 (2001) 31422-31430.
9. S.M. Kornblau, The role of apoptosis in the pathogenesis, prognosis, and therapy of hematologic malignancies, Leukemia 12 (1998) S41-S46.
10. F. Radogna, S. Cristofanon, L. Paternoster, M. D'Alessio, M.D. Nicola, C. Cerella, et al., Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2, Pineal Res. 44 (2008) 316-325.
11. S. Cory, D.C. Huang, J.M. Adams, The Bcl-2 family: roles in cell survival and oncogenesis, Oncogene 22 (2003) 8590-8607.
12. X.H. Cao, A.H. Wang, C.L. Wang, et al., Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway, Chem. Biol. Interact. 183 (2010) 357-362.
13. 2+ regulating extracellular-related protein kinase ERK activation, Cancer Lett. 2 (2009) 221-227.
14. X. Cao, A.H. Wang, R.Z. Jiao, C.L. Wang, D.Z. Mao, L. Yan, et al., Surfactin induces apoptosis and G2/M arrest in human breast cancer MCF-7 cells through cell cycle factor regulation, Cell Biochem. Biophys. 55 (2009) 163-171.
15. C. Vasutakarn, Y. Sanvarinda, C. Sukumal, Reactive oxygen species production and MAPK activation are implicated in tetrahydrobiopterin-induced SH-SY5Y cell death, Neurosci. Lett. 3 (2009) 178-182.
16. A.k. Hirakawa, N.S. Takeyama, T.S. Nakatani, T. Tanaka, Mitochondrial permeability transition and cytochrome release in ischemia-reperfusion injury of the rat liver, J. Surg. Res. 2 (2003) 240-247.
17. C. Lee, D.W. Park, J. Lee, T.I. Lee, Y.J. Kim, Y.S. Lee, et al., Secretory phospholipase A2 induces apoptosis through TNF-a and cytochrome c-mediated caspase cascade in murine macrophage RAW 264.7 cells, Eur. J. Pharmacol. 536 (2006) 47-53.
18. V. Senthil, S. Ramadevi, V. Venkatakrishnan, et al., Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation, Chem. Biol. Interact. 1 (2007) 19-30.
19. P.H. Andrew, What is the mitochondrial permeability transition pore?, J Mol. Cell. Cardiol. 6 (2009) 821-831.
20. M. José, H. García, D.M. Irene, et al., Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation, BBA-Bioenerg. 1797 (2010) 981-993.
21. R.A. Karmali, L. Adams, J.R. Trout, Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenocarcinoma cells, Prostaglandins Leukot. Essent. Fatty Acids 48 (1993) 309-314.
22. M. Noguchi, M. Minami, R. Yagasaki, et al., Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA, Br. J. Cancer 75 (1997) 348-353.
23. P.B.S. Lai, J.A. Ross, K.C.H. Fearon, J.D. Anderson, D.C. Carter, Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro, Br. J. Cancer 74 (1996) 1375-1383.
24. X.H. Liu, D.P. Rose, Suppression of type IV collagenase in MDA-MB-435 human breast cancer cells by eicosapentaenoic acid in vitro and in vivo, Cancer Lett. 92 (1995) 21-26.
25. S.H. Kaufmann, M.O. Hengartner, Programmed cell death: alive and well in the new millennium, Trends Cell Biol. 11 (2001) 526-534.
26. H.U. Simon, A.H. Yehia, F.L. Schaffer, Role of reactive oxygen species (ROS) in apoptosis induction, Apoptosis 5 (2000) 415-418.
27. D.J. McConkey, S. Orrenius, The role of calcium in the regulation of apoptosis, J. Leukoc. Biol. 59 (1996) 775-783.
28. K.R. Martin, J.C. Barrett, Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity, Hum. Exp. Toxicol. 21 (2002) 71-75.
29. J. Yang, X. Liu, K. Bhalla, et al., Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science 275 (1997) 1129-1132.
30. A.P. Halestrap, S.J. Clarke, S.A. Javadov, Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection, Cardiovasc. Res. 61 (2004) 372-385.
31. T.A. Khavari, J. Rinn, Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia, Cell Cycle 6 (2007) 2928-2931.
32. R.M. Kluck, E. Bossy-Wetzel, D.R. Green, D.D. Newmeyer, The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis, Science 275 (1997) 1132-1136.
33. Seongho Ryu, Shih-chieh Lin, Nadia Ugel, Marco Antoniotti, Bud Mishra, Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis, Syst. Synth. Biol. 2 (2008) 49-66.
34. H.E. Kim, F. Du, M. Fang, X. Wang, Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1, Proc. Natl. Acad. Sci. 102 (2005) 17545-17550.