Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1797, Issue 6-7, 2010, Pages 981-993

  García Heredia, José M ^a   Díaz Moreno, Irene ^a   Nieto, Pedro M ^b   Orzáez, Mar ^c   Kocanis, Stella ^a   Teixeira, Miguel ^d   Pérez Payá, Enrique ^c   Díaz Quintana, Antonio ^a   De la Rosa, Miguel A ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

^c CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^d INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Alkaline transition; Apoptosis; Cytochrome c; Peroxidase activity; Post translational modification; Tyrosine nitration

Indexed keywords

CASPASE 9; CYTOCHROME C; PHENYLALANINE; TYROSINE;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MUTANT; NITRATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; THERMOSTABILITY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; APOPTOSIS; CASPASE 9; CYTOCHROMES C; ENZYME ACTIVATION; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NITRO COMPOUNDS; PEROXIDASES; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TYROSINE;

EID: 77953811292     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2010.03.009     Document Type: Article

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