Detection of conformation types of cyclosporin retaining intramolecular hydrogen bonds by mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 24, 2014, Pages 5785-5794

  Hyung, Suk Joon ^a   Feng, Xidong ^a   Che, Ye ^a   Stroh, Justin G ^a   Shapiro, Michael ^a  

^a PFIZER INC   (United States)

Author keywords

Cyclic peptide; Cyclosporine; Hydrogen deuterium exchange; Ion mobility mass spectrometry; Peptide structure

Indexed keywords

CHAINS; CONFORMATIONS; DEUTERIUM; DRUG PRODUCTS; ION EXCHANGE; ION MOBILITY SPECTROMETERS; IONS; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PEPTIDES;

CYCLIC PEPTIDES; CYCLOSPORINE; HYDROGEN-DEUTERIUM EXCHANGE; ION MOBILITY-MASS SPECTROMETRY; PEPTIDE STRUCTURES;

HYDROGEN BONDS;

CYCLOSPORIN DERIVATIVE;

CHEMISTRY; CONFORMATION; HYDROGEN BOND; MASS SPECTROMETRY;

CYCLOSPORINS; HYDROGEN BONDING; MASS SPECTROMETRY; MOLECULAR CONFORMATION;

EID: 84921067571     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-8023-1     Document Type: Article

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