Impaired NLRP3 inflammasome activity during fetal development regulates IL-1β production in human monocytes

European Journal of Immunology

Volumn 45, Issue 1, 2015, Pages 238-249

  Sharma, Ashish A ^a,b   Jen, Roger ^a,b   Kan, Bernard ^a,b   Sharma, Abhinav ^a   Marchant, Elizabeth ^a,b   Tang, Anthony ^a,b   Gadawski, Izabelle ^b   Senger, Christof ^b   Skoll, Amanda ^b   Turvey, Stuart E ^a,b   Sly, Laura M ^a,b   Côté, Hélène C F ^b   Lavoie, Pascal M ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Human; Inflammasome; Interleukin 1 beta (IL 1 ); Neonate; Toll like receptor

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CRYOPYRIN; HLA DR ANTIGEN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR AGONIST; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CYTOSKELETON PROTEIN; NLRP3 PROTEIN, HUMAN; PURINERGIC P2X7 RECEPTOR; PYCARD PROTEIN, HUMAN; TOLL LIKE RECEPTOR;

ADULT; APOPTOSIS; ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS DEVELOPMENT; FLOW CYTOMETRY; GESTATIONAL AGE; HUMAN; HUMAN CELL; MONOCYTE; NEWBORN; NORMAL HUMAN; PLACENTA DISORDER; PLACENTAL INFECTION; PREMATURITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD; UPREGULATION; WESTERN BLOTTING; CYTOLOGY; DRUG EFFECTS; FETUS; FETUS BLOOD; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MACROPHAGE; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ADULT; CARRIER PROTEINS; CYTOSKELETAL PROTEINS; FETAL BLOOD; FETAL DEVELOPMENT; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84921064072     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444707     Document Type: Article

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