Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 2, 2011, Pages 846-851

  Thrane, Alexander S ^a,b,c   Rappold, Phillip M ^a   Fujita, Takumi ^a   Torres, Arnulfo ^a   Bekar, Lane K ^a   Takano, Takahiro ^a   Peng, Weiguo ^a   Wang, Fushun ^a   Thrane, Vinita Rangroo ^a,b,c   Enger, Rune ^b,c   Haj Yasein, Nadia N ^b,c   Skare, Øivind ^d,e   Holen, Torgeir ^b   Klungland, Arne ^f   Ottersen, Ole P ^b   Nedergaard, Maiken ^a   Nagelhus, Erlend A ^a,b,c,f  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^e UNIVERSITY OF BERGEN   (Norway)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Endfeet; Glial; Two photon

Indexed keywords

AQUAPORIN 4; BLOCKING AGENT; CALCIUM ION; PURINERGIC P2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN EDEMA; BRAIN SLICE; BRAIN WATER; CALCIUM SIGNALING; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE FUNCTION; HYPOOSMOTIC STRESS; IN VIVO STUDY; MOLECULAR IMAGING; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OSMOLARITY; OSMOTIC STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TWO PHOTON IMAGING;

ADENOSINE TRIPHOSPHATE; ANIMALS; AQUAPORIN 4; ASTROCYTES; BRAIN; BRAIN EDEMA; CALCIUM; EDEMA; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSMOSIS; PHOTONS; SIGNAL TRANSDUCTION; WATER;

EID: 79551665054     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015217108     Document Type: Article

References (26)

1. Nase G, Helm PJ, Enger R, Ottersen OP (2008) Water entry into astrocytes during brain edema formation. Glia 56:895-902.
2. Amiry-Moghaddam M, Ottersen OP (2003) The molecular basis of water transport in the brain. Nat Rev Neurosci 4:991-1001.
3. Verkman AS (2009) Knock-out models reveal new aquaporin functions. Handb Exp Pharmacol 190:359-381.
4. Nielsen S, et al. (1997) Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17: 171-180. (Pubitemid 27008860)
5. Mathiisen TM, Lehre KP, Danbolt NC, Ottersen OP (2010) The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction. Glia 58:1094-1103.
6. Mulligan SJ, MacVicar BA (2006) VRACs CARVe a path for novel mechanisms of communication in the CNS. Sci STKE 2006:pe42.
7. Kimelberg HK (2005) Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy. Glia 50:389-397.
8. Manley GT, et al. (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159-163.
9. Nagelhus EA, Lehmann A, Ottersen OP (1993) Neuronal-glial exchange of taurine during hypo-osmotic stress: A combined immunocytochemical and biochemical analysis in rat cerebellar cortex. Neuroscience 54:615-631.
10. Risher WC, Andrew RD, Kirov SA (2009) Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices and in vivo revealed by two-photon microscopy. Glia 57:207-221.
11. Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F (2004) Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods 1:31-37.
12. Kang J, et al. (2010) Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons. Neuroscience 169:1601-1609.
13. Regan MR, et al. (2007) Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. J Neurosci 27:6607-6619.
14. Hoffmann EK, Lambert IH, Pedersen SF (2009) Physiology of cell volume regulation in vertebrates. Physiol Rev 89:193-277.
15. Kimelberg HK, Macvicar BA, Sontheimer H (2006) Anion channels in astrocytes: Biophysics, pharmacology, and function. Glia 54:747-757.
16. Papadopoulos MC, Verkman AS (2005) Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem280:13906-13912.
17. Salter MW, Hicks JL (1994) ATP-evoked increases in intracellular calcium in neurons and glia from the dorsal spinal cord. J Neurosci 14:1563-1575.
18. Shao Y, McCarthy KD (1995) Receptor-mediated calcium signals in astroglia: multiple receptors, common stores and all-or-nothing responses. Cell Calcium 17:187-196.
19. Wang X, Ge S, Crooks GM (2009) Fluorescent immunohistochemistry and in situ hybridization analysis of pancreas. Methods Mol Biol 560:191-201.
20. Amiry-Moghaddam M, et al. (2003) Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. Proc Natl Acad Sci USA 100:2106-2111.
21. Rossi DJ, Brady JD, Mohr C (2007) Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 10:1377-1386. (Pubitemid 350014689)
22. Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M (2003) Signaling at the gliovascular interface. J Neurosci 23:9254-9262.
23. Wang X, et al. (2006) Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo. Nat Neurosci 9:816-823.
24. Cnaan A, Laird NM, Slasor P (1997) Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Stat Med 16:2349-2380. (Pubitemid 27458250)
25. Kang J, Nedergaard M (2000) Imaging astrocytes in acute brain slices. Imaging Neurons: A Laboratory Manual, eds Yuste R, Lanni F, Konnerth A (Cold Spring Harbor Laboratory Press, Plainview, NY), pp 1-42.
26. Cotrina ML, et al. (1998) Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci USA 95:15735-15740.