An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation

Cell Reports

Volumn 10, Issue 1, 2015, Pages 29-38

  Lu, Chao ^a,b   Ward, Alyssa ^a   Bettridge, John ^a   Liu, Yun ^a   Desiderio, Stephen ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; PROTEIN RAG 2; RECOMBINASE; TRANSPOSASE; UNCLASSIFIED DRUG; V(D)J RECOMBINASE; CHROMATIN; DNA BINDING PROTEIN; HISTONE; HISTONE DEMETHYLASE; HOMEODOMAIN PROTEIN; PROTEIN BINDING; RAG-1 PROTEIN; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

ACTIVE CHROMATIN; ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; AUTOINHIBITORY DOMAIN; AUTOREGULATION; BINDING AFFINITY; CATALYSIS; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA MODIFICATION; ENZYME SUBSTRATE COMPLEX; EPIGENETICS; GAIN OF FUNCTION MUTATION; HISTONE METHYLATION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PHENOTYPE; PLANT HOMEODOMAIN FINGER; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL END COMPLEX; STRUCTURE ACTIVITY RELATION; VDJ RECOMBINATION; WILD TYPE; 3T3 CELL LINE; ANIMAL; BINDING SITE; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; METHYLATION; MOUSE;

ANIMALS; BINDING SITES; CHROMATIN; DNA-BINDING PROTEINS; HEK293 CELLS; HISTONE DEMETHYLASES; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; METHYLATION; MICE; NIH 3T3 CELLS; PROTEIN BINDING; V(D)J RECOMBINATION; VDJ RECOMBINASES;

EID: 84920928380     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.12.001     Document Type: Article

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