In situ NIR spectroscopy monitoring of plasmid production processes: Effect of producing strain, medium composition and the cultivation strategy

Journal of Chemical Technology and Biotechnology

Volumn 90, Issue 2, 2015, Pages 255-261

  Lopes, Marta B ^a   Gonçalves, Geisa A L ^b   Felício Silva, Daniel ^a   Prather, Kristala L J ^c   Monteiro, Gabriel A ^b   Prazeres, Duarte M F ^b   Calado, Cecília R C ^a  

^a CATHOLIC UNIVERSITY OF PORTUGAL   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^c Massachusetts Institute of Technology   (United States)

Author keywords

Escherichia coli; in situ monitoring; Near infrared spectroscopy; Plasmid bioprocess

Indexed keywords

ESCHERICHIA COLI; FORECASTING; GENE THERAPY; INFRARED DEVICES; LEAST SQUARES APPROXIMATIONS; NEAR INFRARED SPECTROSCOPY; REGRESSION ANALYSIS;

BIOPROCESSES; CRITICAL VARIABLES; FED-BATCH CULTIVATION; IN- SITU MONITORING; PARTIAL LEAST-SQUARES REGRESSION; PHARMACEUTICAL INDUSTRY; PRODUCTION PROCESS; REAL TIME MONITORING;

DNA;

ACETIC ACID; GLUCOSE; GLYCEROL;

ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOCHEMICAL COMPOSITION; BIOLOGICAL MONITORING; BIOMASS; BIOPROCESS; CARBON SOURCE; CONTROLLED STUDY; CULTURE MEDIUM; ESCHERICHIA COLI; FED BATCH CULTURE; GENETIC ENGINEERING; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PLASMID; PREDICTION; STATISTICAL MODEL;

ESCHERICHIA COLI;

EID: 84920914661     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.4431     Document Type: Article

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