Rational engineering of Escherichia coli strains for plasmid biopharmaceutical manufacturing

Biotechnology Journal

Volumn 7, Issue 2, 2012, Pages 251-261

  Gonçalves, Geisa A L ^a,b   Bower, Diana M ^c   Prazeres, Duarte M F ^a,b   Monteiro, Gabriel A ^a,b   Prather, Kristala L J ^c  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b Instituto de Biotecnologia e Bioengenharia Lisboa   (Portugal)

^c USA   (United States)

Author keywords

Central metabolism; Escherichia coli; Metabolic engineering; Plasmid biopharmaceuticals; Strain engineering

Indexed keywords

BIOPHARMACEUTICALS; CLINICAL TRIAL; DNA VACCINATION; DOWNSTREAM-PROCESSING; E. COLI; ECONOMICAL IMPROVEMENT; ESSENTIAL GENE; PLASMID DNA; PLASMID DNA (PDNA); PRODUCTION STRAIN; RECOMBINANT PROTEIN PRODUCTIONS; STRAIN ENGINEERING; VETERINARY APPLICATIONS;

BIOMOLECULES; DNA; ESCHERICHIA COLI; GENE EXPRESSION; METABOLIC ENGINEERING;

MANUFACTURE;

PLASMID DNA;

BACTERIAL STRAIN; BIOENGINEERING; CARBON METABOLISM; DNA SYNTHESIS; DRUG MANUFACTURE; ESCHERICHIA COLI; FERMENTATION; GENETIC ENGINEERING; GENETIC RECOMBINATION; GENETIC TRANSFECTION; HUMAN; MEDICAL TECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REVIEW;

BIOPHARMACEUTICS; CELL LINE; ESCHERICHIA COLI; HUMANS; METABOLIC ENGINEERING; PLASMIDS;

ESCHERICHIA COLI;

EID: 84856575274     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201100062     Document Type: Review

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