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Volumn 35, Issue 1, 2015, Pages 23-31

Possible Contribution of Proteins of Bcl-2 Family in Neuronal Death Following Transient Global Brain Ischemia

Author keywords

Akt kinase; Bcl 2 protein family; Extracellular signal regulated kinase; Global brain ischemia; Mitochondrial apoptosis; Ubiquitin proteasome system

Indexed keywords

BIM PROTEIN; CELL EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN MCL 1; PROTEIN NOXA; PUMA PROTEIN; UBIQUITIN;

EID: 84920889499     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-014-0104-3     Document Type: Article
Times cited : (27)

References (58)
  • 1
    • 2142771705 scopus 로고    scopus 로고
    • Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia
    • COI: 1:CAS:528:DC%2BD2cXjs1Wltrg%3D, PID: 15120593
    • Abe T, Takagi N, Nakano M, Furuya M, Takeo S (2004) Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Brain Res 1009:159–168
    • (2004) Brain Res , vol.1009 , pp. 159-168
    • Abe, T.1    Takagi, N.2    Nakano, M.3    Furuya, M.4    Takeo, S.5
  • 2
    • 84856253626 scopus 로고    scopus 로고
    • Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
    • COI: 1:CAS:528:DC%2BC38XhtFCqu7k%3D, PID: 22260680
    • Aksamitiene E, Kiyatkin A, Kholodenko BN (2012) Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance. Biochem Soc Trans 40:139–146
    • (2012) Biochem Soc Trans , vol.40 , pp. 139-146
    • Aksamitiene, E.1    Kiyatkin, A.2    Kholodenko, B.N.3
  • 4
    • 60849112820 scopus 로고    scopus 로고
    • Tumour cell survival signalling by the ERK1/2 pathway
    • COI: 1:CAS:528:DC%2BD1MXit1Wkurc%3D, PID: 18846109
    • Balmanno K, Cook SJ (2009) Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ 16:368–377
    • (2009) Cell Death Differ , vol.16 , pp. 368-377
    • Balmanno, K.1    Cook, S.J.2
  • 5
    • 84878243521 scopus 로고    scopus 로고
    • Non-apoptotic roles of Bcl-2 family: the calcium connection
    • COI: 1:CAS:528:DC%2BC3sXisVGqtLw%3D, PID: 23360981
    • Bonneau B, Prudent J, Popgeorgiev N, Gillet G (2013) Non-apoptotic roles of Bcl-2 family: the calcium connection. Biochim Biophys Acta 1833:1755–1765
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 1755-1765
    • Bonneau, B.1    Prudent, J.2    Popgeorgiev, N.3    Gillet, G.4
  • 6
    • 0036012750 scopus 로고    scopus 로고
    • Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia
    • COI: 1:CAS:528:DC%2BD38XktlWgsL4%3D, PID: 11973426
    • Cao G, Luo Y, Nagayama T, Pei W, Stetler RA, Graham SH, Chen J (2002) Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia. J Cereb Blood Flow Metab 22:534–546
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 534-546
    • Cao, G.1    Luo, Y.2    Nagayama, T.3    Pei, W.4    Stetler, R.A.5    Graham, S.H.6    Chen, J.7
  • 7
    • 0032124903 scopus 로고    scopus 로고
    • Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
    • COI: 1:CAS:528:DyaK1cXkt1Smt7s%3D, PID: 9634557
    • Chen J, Nagayama T, Jin K, Stetler RA, Zhu RL, Graham SH, Simon RP (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914–4928
    • (1998) J Neurosci , vol.18 , pp. 4914-4928
    • Chen, J.1    Nagayama, T.2    Jin, K.3    Stetler, R.A.4    Zhu, R.L.5    Graham, S.H.6    Simon, R.P.7
  • 8
    • 84862887624 scopus 로고    scopus 로고
    • Ischemia-induced inhibition of mitochondrial complex I in rat brain: effect of permeabilization method and electron acceptor
    • COI: 1:CAS:528:DC%2BC38XisV2jsw%3D%3D, PID: 22219133
    • Chomova M, Tatarkova Z, Dobrota D, Racay P (2012) Ischemia-induced inhibition of mitochondrial complex I in rat brain: effect of permeabilization method and electron acceptor. Neurochem Res 37:965–976
    • (2012) Neurochem Res , vol.37 , pp. 965-976
    • Chomova, M.1    Tatarkova, Z.2    Dobrota, D.3    Racay, P.4
  • 9
    • 84865200787 scopus 로고    scopus 로고
    • NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1
    • COI: 1:CAS:528:DC%2BC38Xht1WltbvM, PID: 22361683
    • Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J, Ciechanover A, Cohen GM (2012) NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death Differ 19:1424–1434
    • (2012) Cell Death Differ , vol.19 , pp. 1424-1434
    • Craxton, A.1    Butterworth, M.2    Harper, N.3    Fairall, L.4    Schwabe, J.5    Ciechanover, A.6    Cohen, G.M.7
  • 10
    • 13844264230 scopus 로고    scopus 로고
    • Transient cerebral ischemia induces delayed proapoptotic Bad translocation to mitochondria in CA1 sector of hippocampus
    • PID: 15710244
    • Dłuzniewska J, Beresewicz M, Wojewódzka U, Gajkowska B, Zabłocka B (2005) Transient cerebral ischemia induces delayed proapoptotic Bad translocation to mitochondria in CA1 sector of hippocampus. Brain Res Mol Brain Res 133:274–280
    • (2005) Brain Res Mol Brain Res , vol.133 , pp. 274-280
    • Dłuzniewska, J.1    Beresewicz, M.2    Wojewódzka, U.3    Gajkowska, B.4    Zabłocka, B.5
  • 11
    • 58149175555 scopus 로고    scopus 로고
    • The life of a cell: apoptosis regulation by the PI3K/PKB pathway
    • COI: 1:CAS:528:DC%2BD1cXht1CmsrnP, PID: 18842113
    • Duronio V (2008) The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 415:333–344
    • (2008) Biochem J , vol.415 , pp. 333-344
    • Duronio, V.1
  • 12
    • 33747056618 scopus 로고    scopus 로고
    • Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats
    • COI: 1:CAS:528:DC%2BD28XnvF2itrc%3D, PID: 16870742
    • Endo H, Kamada H, Nito C, Nishi T, Chan PH (2006a) Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. J Neurosci 26:7974–7983
    • (2006) J Neurosci , vol.26 , pp. 7974-7983
    • Endo, H.1    Kamada, H.2    Nito, C.3    Nishi, T.4    Chan, P.H.5
  • 13
    • 33751331389 scopus 로고    scopus 로고
    • Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats
    • COI: 1:CAS:528:DC%2BD2sXktVSltw%3D%3D, PID: 16538228
    • Endo H, Nito C, Kamada H, Nishi T, Chan PH (2006b) Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. J Cereb Blood Flow Metab 26:1479–1489
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1479-1489
    • Endo, H.1    Nito, C.2    Kamada, H.3    Nishi, T.4    Chan, P.H.5
  • 14
    • 39749136204 scopus 로고    scopus 로고
    • BCL-2 family regulation by the 20S proteasome inhibitor bortezomib
    • COI: 1:CAS:528:DC%2BD1cXit1yms7c%3D, PID: 17828309
    • Fennell DA, Chacko A, Mutti L (2008) BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 27:1189–1197
    • (2008) Oncogene , vol.27 , pp. 1189-1197
    • Fennell, D.A.1    Chacko, A.2    Mutti, L.3
  • 15
    • 84859433796 scopus 로고    scopus 로고
    • Non-apoptotic functions of apoptosis-regulatory proteins
    • COI: 1:CAS:528:DC%2BC38Xjs1WhsLs%3D, PID: 22402666
    • Galluzzi L, Kepp O, Trojel-Hansen C, Kroemer G (2012) Non-apoptotic functions of apoptosis-regulatory proteins. EMBO Rep 13:322–330
    • (2012) EMBO Rep , vol.13 , pp. 322-330
    • Galluzzi, L.1    Kepp, O.2    Trojel-Hansen, C.3    Kroemer, G.4
  • 16
    • 0347363611 scopus 로고    scopus 로고
    • Ischaemic preconditioning in the rat brain: effect on the activity of several initiation factors, Akt and extracellular signal-regulated protein kinase phosphorylation, and GRP78 and GADD34 expression
    • PID: 14675157
    • García L, Burda J, Hrehorovská M, Burda R, Martín ME, Salinas M (2004) Ischaemic preconditioning in the rat brain: effect on the activity of several initiation factors, Akt and extracellular signal-regulated protein kinase phosphorylation, and GRP78 and GADD34 expression. J Neurochem 88:136–147
    • (2004) J Neurochem , vol.88 , pp. 136-147
    • García, L.1    Burda, J.2    Hrehorovská, M.3    Burda, R.4    Martín, M.E.5    Salinas, M.6
  • 18
    • 36448993027 scopus 로고    scopus 로고
    • Protein aggregation and proteasome dysfunction after brain ischemia
    • COI: 1:CAS:528:DC%2BD2sXhtlSlt7jP, PID: 17975104
    • Ge P, Luo Y, Liu CL, Hu B (2007) Protein aggregation and proteasome dysfunction after brain ischemia. Stroke 38:3230–3236
    • (2007) Stroke , vol.38 , pp. 3230-3236
    • Ge, P.1    Luo, Y.2    Liu, C.L.3    Hu, B.4
  • 19
    • 20444430478 scopus 로고    scopus 로고
    • Apoptotic pathways: ten minutes to dead
    • COI: 1:CAS:528:DC%2BD2MXltFyisbY%3D, PID: 15935754
    • Green DR (2005) Apoptotic pathways: ten minutes to dead. Cell 121:671–674
    • (2005) Cell , vol.121 , pp. 671-674
    • Green, D.R.1
  • 20
    • 84861777075 scopus 로고    scopus 로고
    • Multipolar functions of BCL-2 proteins link energetics to apoptosis
    • COI: 1:CAS:528:DC%2BC38XosVGltbg%3D, PID: 22560661
    • Hardwick JM, Chen YB, Jonas EA (2012) Multipolar functions of BCL-2 proteins link energetics to apoptosis. Trends Cell Biol 22:318–328
    • (2012) Trends Cell Biol , vol.22 , pp. 318-328
    • Hardwick, J.M.1    Chen, Y.B.2    Jonas, E.A.3
  • 23
    • 0030038824 scopus 로고    scopus 로고
    • Changes in proteasome activity following transient ischemia
    • COI: 1:CAS:528:DyaK28XislegtA%3D%3D, PID: 8719710
    • Kamikubo T, Hayashi T (1996) Changes in proteasome activity following transient ischemia. Neurochem Int 28:209–212
    • (1996) Neurochem Int , vol.28 , pp. 209-212
    • Kamikubo, T.1    Hayashi, T.2
  • 24
    • 0027181247 scopus 로고
    • Immunohistochemical localization of ubiquitin in gerbil hippocampus with induced tolerance to ischemia
    • COI: 1:CAS:528:DyaK3sXlsFOmsb0%3D, PID: 8397055
    • Kato H, Chen T, Liu XH, Nakata N, Kogure K (1993) Immunohistochemical localization of ubiquitin in gerbil hippocampus with induced tolerance to ischemia. Brain Res 619:339–343
    • (1993) Brain Res , vol.619 , pp. 339-343
    • Kato, H.1    Chen, T.2    Liu, X.H.3    Nakata, N.4    Kogure, K.5
  • 25
    • 0033780693 scopus 로고    scopus 로고
    • Delayed neuronal death
    • PID: 11037198
    • Kirino T (2000) Delayed neuronal death. Neuropathology 20:S95–S97
    • (2000) Neuropathology , vol.20 , pp. S95-S97
    • Kirino, T.1
  • 26
    • 0027988155 scopus 로고
    • Immunohistochemical analysis of in vivo patterns of Bcl-X expression
    • COI: 1:CAS:528:DyaK2cXmvFOlsrY%3D, PID: 7923184
    • Krajewski S, Krajewska M, Shabaik A, Wang HG, Irie S, Fong L, Reed JC (1994) Immunohistochemical analysis of in vivo patterns of Bcl-X expression. Cancer Res 54:5501–5507
    • (1994) Cancer Res , vol.54 , pp. 5501-5507
    • Krajewski, S.1    Krajewska, M.2    Shabaik, A.3    Wang, H.G.4    Irie, S.5    Fong, L.6    Reed, J.C.7
  • 27
    • 0028973310 scopus 로고
    • Upregulation of bax protein levels in neurons following cerebral ischemia
    • COI: 1:CAS:528:DyaK2MXovFWhtLw%3D, PID: 7472401
    • Krajewski S, Mai JK, Krajewska M, Sikorska M, Mossakowski MJ, Reed JC (1995a) Upregulation of bax protein levels in neurons following cerebral ischemia. J Neurosci 15:6364–6376
    • (1995) J Neurosci , vol.15 , pp. 6364-6376
    • Krajewski, S.1    Mai, J.K.2    Krajewska, M.3    Sikorska, M.4    Mossakowski, M.J.5    Reed, J.C.6
  • 28
    • 0029043811 scopus 로고
    • Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo
    • COI: 1:CAS:528:DyaK2MXms1SkurY%3D, PID: 7778670
    • Krajewski S, Bodrug S, Krajewska M, Shabaik A, Gascoyne R, Berean K, Reed JC (1995b) Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol 146:1309–1319
    • (1995) Am J Pathol , vol.146 , pp. 1309-1319
    • Krajewski, S.1    Bodrug, S.2    Krajewska, M.3    Shabaik, A.4    Gascoyne, R.5    Berean, K.6    Reed, J.C.7
  • 30
    • 1942457291 scopus 로고    scopus 로고
    • Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization
    • COI: 1:CAS:528:DC%2BD2cXjsV2jtbs%3D, PID: 15084669
    • Lein ES, Zhao X, Gage FH (2004) Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci 24:3879–3889
    • (2004) J Neurosci , vol.24 , pp. 3879-3889
    • Lein, E.S.1    Zhao, X.2    Gage, F.H.3
  • 31
    • 0033982565 scopus 로고    scopus 로고
    • Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats
    • COI: 1:CAS:528:DC%2BD3cXmsVGhtA%3D%3D, PID: 10625735
    • Li H, Colbourne F, Sun P, Zhao Z, Buchan AM (2000) Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats. Stroke 31:176–182
    • (2000) Stroke , vol.31 , pp. 176-182
    • Li, H.1    Colbourne, F.2    Sun, P.3    Zhao, Z.4    Buchan, A.M.5
  • 32
    • 79952700828 scopus 로고    scopus 로고
    • Bcl-2 proteins and mitochondria–specificity in membrane targeting for death
    • COI: 1:CAS:528:DC%2BC3MXjsFCgs7Y%3D, PID: 21056595
    • Lindsay J, Esposti MD, Gilmore AP (2011) Bcl-2 proteins and mitochondria–specificity in membrane targeting for death. Biochim Biophys Acta 1813:532–539
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 532-539
    • Lindsay, J.1    Esposti, M.D.2    Gilmore, A.P.3
  • 33
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • COI: 1:STN:280:DyaK1MvjvVagtw%3D%3D, PID: 10508238
    • Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431–1568
    • (1999) Physiol Rev , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 34
    • 42449095582 scopus 로고    scopus 로고
    • Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons
    • COI: 1:CAS:528:DC%2BD1cXktlSjsLc%3D, PID: 18347331
    • Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MV, Zukin RS, Jonas EA (2008) Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proc Natl Acad Sci USA 105:4892–4897
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 4892-4897
    • Miyawaki, T.1    Mashiko, T.2    Ofengeim, D.3    Flannery, R.J.4    Noh, K.M.5    Fujisawa, S.6    Bonanni, L.7    Bennett, M.V.8    Zukin, R.S.9    Jonas, E.A.10
  • 35
    • 0030044329 scopus 로고    scopus 로고
    • Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons
    • COI: 1:CAS:528:DyaK28Xitlahsb8%3D, PID: 8546212
    • Morimoto T, Ide T, Ihara Y, Tamura A, Kirino T (1996) Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons. Am J Pathol 148:249–257
    • (1996) Am J Pathol , vol.148 , pp. 249-257
    • Morimoto, T.1    Ide, T.2    Ihara, Y.3    Tamura, A.4    Kirino, T.5
  • 36
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
    • COI: 1:CAS:528:DyaK2MXktlCltLk%3D, PID: 7878471
    • Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506–1510
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1    Wang, F.2    Roth, K.A.3    Sawa, H.4    Nakayama, K.5    Negishi, I.6    Senju, S.7    Zhang, Q.8    Fujii, S.9
  • 37
    • 49449106453 scopus 로고    scopus 로고
    • Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities
    • COI: 1:CAS:528:DC%2BD1cXmsVOjsrc%3D, PID: 18066503
    • Nakka VP, Gusain A, Mehta SL, Raghubir R (2008) Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol 37:7–38
    • (2008) Mol Neurobiol , vol.37 , pp. 7-38
    • Nakka, V.P.1    Gusain, A.2    Mehta, S.L.3    Raghubir, R.4
  • 38
    • 60549117084 scopus 로고    scopus 로고
    • Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia
    • COI: 1:CAS:528:DC%2BD1MXmvVeitQ%3D%3D, PID: 19095966
    • Niizuma K, Endo H, Nito C, Myer DJ, Chan PH (2009) Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Stroke 40:618–625
    • (2009) Stroke , vol.40 , pp. 618-625
    • Niizuma, K.1    Endo, H.2    Nito, C.3    Myer, D.J.4    Chan, P.H.5
  • 41
    • 0018347695 scopus 로고
    • A new model of bilateral hemispheric ischemia in the unanesthetized rat
    • COI: 1:STN:280:DyaE1M3is1amtQ%3D%3D, PID: 37614
    • Pulsinelli WA, Brierley JB (1979) A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10:267–272
    • (1979) Stroke , vol.10 , pp. 267-272
    • Pulsinelli, W.A.1    Brierley, J.B.2
  • 42
    • 84856531737 scopus 로고    scopus 로고
    • Ischaemia-induced protein ubiquitinylation is differentially accompanied with heat-shock protein 70 expression after naïve and preconditioned ischaemia
    • COI: 1:CAS:528:DC%2BC38XhtFCqtLg%3D, PID: 21789629
    • Racay P (2012) Ischaemia-induced protein ubiquitinylation is differentially accompanied with heat-shock protein 70 expression after naïve and preconditioned ischaemia. Cell Mol Neurobiol 32:107–119
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 107-119
    • Racay, P.1
  • 43
    • 34848857903 scopus 로고    scopus 로고
    • Effect of ischemic preconditioning on mitochondrial dysfunction and mitochondrial p53 translocation after transient global cerebral ischemia in rats
    • COI: 1:CAS:528:DC%2BD2sXhtV2mtr7I, PID: 17661174
    • Racay P, Tatarkova Z, Drgova A, Kaplan P, Dobrota D (2007) Effect of ischemic preconditioning on mitochondrial dysfunction and mitochondrial p53 translocation after transient global cerebral ischemia in rats. Neurochem Res 32:1823–1832
    • (2007) Neurochem Res , vol.32 , pp. 1823-1832
    • Racay, P.1    Tatarkova, Z.2    Drgova, A.3    Kaplan, P.4    Dobrota, D.5
  • 44
    • 68149180674 scopus 로고    scopus 로고
    • Ischemia-induced mitochondrial apoptosis is significantly attenuated by ischemic preconditioning
    • COI: 1:CAS:528:DC%2BD1MXptFCksrw%3D, PID: 19283470
    • Racay P, Chomova M, Tatarkova Z, Kaplan P, Hatok J, Dobrota D (2009) Ischemia-induced mitochondrial apoptosis is significantly attenuated by ischemic preconditioning. Cell Mol Neurobiol 29:901–908
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 901-908
    • Racay, P.1    Chomova, M.2    Tatarkova, Z.3    Kaplan, P.4    Hatok, J.5    Dobrota, D.6
  • 45
    • 79952705597 scopus 로고    scopus 로고
    • Integrating stress signals at the endoplasmic reticulum: the BCL-2 protein family rheostat
    • COI: 1:CAS:528:DC%2BC3MXjsFCgsL0%3D, PID: 21122809
    • Rodriguez D, Rojas-Rivera D, Hetz C (2011) Integrating stress signals at the endoplasmic reticulum: the BCL-2 protein family rheostat. Biochim Biophys Acta 1813:564–574
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 564-574
    • Rodriguez, D.1    Rojas-Rivera, D.2    Hetz, C.3
  • 46
    • 75549087565 scopus 로고    scopus 로고
    • Insulin activates the PI3K-Akt survival pathway in vulnerable neurons following global brain ischemia
    • COI: 1:CAS:528:DC%2BC3cXisVCqtg%3D%3D, PID: 19203442
    • Sanderson TH, Kumar R, Murariu-Dobrin AC, Page AB, Krause GS, Sullivan JM (2009) Insulin activates the PI3K-Akt survival pathway in vulnerable neurons following global brain ischemia. Neurol Res 31:947–958
    • (2009) Neurol Res , vol.31 , pp. 947-958
    • Sanderson, T.H.1    Kumar, R.2    Murariu-Dobrin, A.C.3    Page, A.B.4    Krause, G.S.5    Sullivan, J.M.6
  • 47
    • 45549105772 scopus 로고    scopus 로고
    • Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke
    • COI: 1:CAS:528:DC%2BD1cXnt1ektLc%3D, PID: 18189318
    • Sawe N, Steinberg G, Zhao H (2008) Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke. J Neurosci Res 86:1659–1669
    • (2008) J Neurosci Res , vol.86 , pp. 1659-1669
    • Sawe, N.1    Steinberg, G.2    Zhao, H.3
  • 48
    • 34248642353 scopus 로고    scopus 로고
    • Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia
    • Sugawara T, Fujimura M, Morita-Fujimura Y, Kawase M, Chan PH (1999) Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J Neurosci 19:1–6
    • (1999) J Neurosci , vol.19 , pp. 1-6
    • Sugawara, T.1    Fujimura, M.2    Morita-Fujimura, Y.3    Kawase, M.4    Chan, P.H.5
  • 49
    • 0035844225 scopus 로고    scopus 로고
    • Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells
    • COI: 1:CAS:528:DC%2BD3MXjvFaktbw%3D, PID: 11278671
    • Sun YF, Yu LY, Saarma M, Timmusk T, Arumae U (2001) Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells. J Biol Chem 276:16240–16270
    • (2001) J Biol Chem , vol.276 , pp. 16240-16270
    • Sun, Y.F.1    Yu, L.Y.2    Saarma, M.3    Timmusk, T.4    Arumae, U.5
  • 52
    • 39749182234 scopus 로고    scopus 로고
    • Apoptosis: controlled demolition at the cellular level
    • COI: 1:CAS:528:DC%2BD1cXitlGnurs%3D, PID: 18073771
    • Taylor RC, Cullen SP, Martin SJ (2008) Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9:231–241
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 231-241
    • Taylor, R.C.1    Cullen, S.P.2    Martin, S.J.3
  • 54
    • 0037134431 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase (PI3 K)-Akt pathway suppresses Bax translocation to mitochondria
    • COI: 1:CAS:528:DC%2BD38XjsFWnt7w%3D, PID: 11842081
    • Tsuruta F, Masuyama N, Gotoh Y (2002) The phosphatidylinositol 3-kinase (PI3 K)-Akt pathway suppresses Bax translocation to mitochondria. J Biol Chem 277:14040–14047
    • (2002) J Biol Chem , vol.277 , pp. 14040-14047
    • Tsuruta, F.1    Masuyama, N.2    Gotoh, Y.3
  • 55
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • COI: 1:CAS:528:DyaK2MXjtlGns78%3D, PID: 7834748
    • Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285–291
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 56
    • 18844452864 scopus 로고    scopus 로고
    • Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation
    • COI: 1:CAS:528:DC%2BD2MXksFKnsr8%3D, PID: 15857405
    • Yin XH, Zhang QG, Miao B, Zhang GY (2005) Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation. J Neurochem 93:1021–1029
    • (2005) J Neurochem , vol.93 , pp. 1021-1029
    • Yin, X.H.1    Zhang, Q.G.2    Miao, B.3    Zhang, G.Y.4
  • 57
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: opposing activities that mediate cell death
    • COI: 1:CAS:528:DC%2BD2sXhsVKrsrrP, PID: 18097445
    • Youle RJ, Strasser A (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9:47–59
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 58
    • 77952820363 scopus 로고    scopus 로고
    • Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737
    • COI: 1:CAS:528:DC%2BC3cXltFOls7c%3D, PID: 20307556
    • Young KW, Piñón LG, Dhiraj D, Twiddy D, Macfarlane M, Hickman J, Nicotera P (2010) Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737. Neuropharmacology 58:1258–1267
    • (2010) Neuropharmacology , vol.58 , pp. 1258-1267
    • Young, K.W.1    Piñón, L.G.2    Dhiraj, D.3    Twiddy, D.4    Macfarlane, M.5    Hickman, J.6    Nicotera, P.7


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