Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension

Journal of Biological Chemistry

Volumn 290, Issue 2, 2015, Pages 960-971

  Prewitt, Allison R ^a   Ghose, Sampa ^b   Frump, Andrea L ^a   Datta, Arumima ^b   Austin, Eric D ^b   Kenworthy, Anne K ^a   De Caestecker, Mark P ^b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELL MEMBRANES; DEFECTS; ENDOTHELIAL CELLS; ENZYMES; GENES; MOLECULAR BIOLOGY; RESTORATION;

BONE MORPHOGENETIC PROTEINS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL FUNCTION; ENDOTHELIAL PROGENITOR CELLS; INTRACELLULAR LOCALIZATION; PULMONARY ARTERIAL HYPERTENSION; PULMONARY VASCULATURE; VASCULAR PERMEABILITY;

PROTEINS;

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CAVEOLIN 1; CAVIN 1; DYNASORE; PROTEIN TYROSINE KINASE; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG; BMP2 PROTEIN, HUMAN; BMPR2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BMPR2 GENE; CAVEOLA; CELL COUNT; CELL GROWTH; CELL ISOLATION; CELL MEMBRANE; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; LUNG ENDOTHELIUM; MOUSE; NONHUMAN; PULMONARY HYPERTENSION; ANIMAL; ANTAGONISTS AND INHIBITORS; ENDOTHELIUM CELL; FRAMESHIFT MUTATION; GENETICS; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN TRANSPORT;

CHICKEN ANEMIA VIRUS; MUS;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CAVEOLAE; CAVEOLIN 1; ENDOCYTOSIS; ENDOTHELIAL CELLS; FAMILIAL PRIMARY PULMONARY HYPERTENSION; FRAMESHIFT MUTATION; HETEROZYGOTE; HUMANS; LUNG; MICE; PROTEIN TRANSPORT; PYRIMIDINES; SRC-FAMILY KINASES;

EID: 84920885225     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.591057     Document Type: Article

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