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Volumn 230, Issue 3, 2015, Pages 620-629

Thymoquinone restores radiation-induced TGF-β expression and abrogates EMT in chemoradiotherapy of breast cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CD51 ANTIGEN; CYTOKERATIN 19; GELATINASE A; GELATINASE B; PACLITAXEL; RADIOSENSITIZING AGENT; THYMOQUINONE; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; BENZOQUINONE DERIVATIVE;

EID: 84920868180     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24780     Document Type: Article
Times cited : (46)

References (54)
  • 1
    • 27144468987 scopus 로고    scopus 로고
    • Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice
    • Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE. 2005. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11:7490-7498.
    • (2005) Clin Cancer Res , vol.11 , pp. 7490-7498
    • Aggarwal, B.B.1    Shishodia, S.2    Takada, Y.3    Banerjee, S.4    Newman, R.A.5    Bueso-Ramos, C.E.6    Price, J.E.7
  • 3
    • 0027293946 scopus 로고
    • Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland
    • Barcellos-Hoff MH. 1993. Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res 53:3880-3886.
    • (1993) Cancer Res , vol.53 , pp. 3880-3886
    • Barcellos-Hoff, M.H.1
  • 4
    • 84863264554 scopus 로고    scopus 로고
    • Cancer and radiation therapy: Current advances and future directions
    • Baskar R, Lee KA, Yeo R, Yeoh KW. 2012. Cancer and radiation therapy: Current advances and future directions. Int J Med Sci 9:193-199.
    • (2012) Int J Med Sci , vol.9 , pp. 193-199
    • Baskar, R.1    Lee, K.A.2    Yeo, R.3    Yeoh, K.W.4
  • 6
    • 34248185926 scopus 로고    scopus 로고
    • Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
    • Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL. 2007. Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest 117:1305-1313.
    • (2007) J Clin Invest , vol.117 , pp. 1305-1313
    • Biswas, S.1    Guix, M.2    Rinehart, C.3    Dugger, T.C.4    Chytil, A.5    Moses, H.L.6    Freeman, M.L.7    Arteaga, C.L.8
  • 7
    • 84888307922 scopus 로고    scopus 로고
    • Transforming growth factor β-1 (TGF-β1) is a serum biomarker of radiation induced fibrosis in patients treated with intracavitary accelerated partial breast irradiation: Preliminary results of a prospective study
    • Boothe DL, Coplowitz S, Greenwood E, Barney CL, Christos PJ, Parashar B, Nori D, Chao KSC, Wernicke AG. 2013. Transforming growth factor β-1 (TGF-β1) is a serum biomarker of radiation induced fibrosis in patients treated with intracavitary accelerated partial breast irradiation: Preliminary results of a prospective study. Int J Rad Oncol Biol Phys 87:1030-1036.
    • (2013) Int J Rad Oncol Biol Phys , vol.87 , pp. 1030-1036
    • Boothe, D.L.1    Coplowitz, S.2    Greenwood, E.3    Barney, C.L.4    Christos, P.J.5    Parashar, B.6    Nori, D.7    Chao, K.S.C.8    Wernicke, A.G.9
  • 8
    • 84866390484 scopus 로고    scopus 로고
    • Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells
    • Boudreau HE, Casterline BW, Rada B, Korzeniowska A, Leto TL. 2012. Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells. Free Radic Biol Med 53:1489-1499.
    • (2012) Free Radic Biol Med , vol.53 , pp. 1489-1499
    • Boudreau, H.E.1    Casterline, B.W.2    Rada, B.3    Korzeniowska, A.4    Leto, T.L.5
  • 10
    • 14044253040 scopus 로고    scopus 로고
    • Combining radiation and molecular targeting in cancer therapy
    • Camphausen K, Tofilon PJ. 2004. Combining radiation and molecular targeting in cancer therapy. Cancer Biol Ther 3:247-250.
    • (2004) Cancer Biol Ther , vol.3 , pp. 247-250
    • Camphausen, K.1    Tofilon, P.J.2
  • 11
    • 1542426626 scopus 로고    scopus 로고
    • Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3
    • Chendil D, Ranga RS, Meigooni D, Sathishkumar S, Ahmed MM. 2004. Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene 23:1599-1607.
    • (2004) Oncogene , vol.23 , pp. 1599-1607
    • Chendil, D.1    Ranga, R.S.2    Meigooni, D.3    Sathishkumar, S.4    Ahmed, M.M.5
  • 13
    • 84856017848 scopus 로고    scopus 로고
    • Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer
    • Dai Y, Desano J, Qu Y, Tang W, Meng Y, Lawrence TS, Xu L. 2011. Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer. Am J Cancer Res 1:128-143.
    • (2011) Am J Cancer Res , vol.1 , pp. 128-143
    • Dai, Y.1    Desano, J.2    Qu, Y.3    Tang, W.4    Meng, Y.5    Lawrence, T.S.6    Xu, L.7
  • 14
    • 77953426073 scopus 로고    scopus 로고
    • Role of radiation-induced TGF-beta signaling in cancer therapy
    • Dancea HC, Shareef MM, Ahmed MM. 2009. Role of radiation-induced TGF-beta signaling in cancer therapy. Mol Cell Pharmacol 1:44-56.
    • (2009) Mol Cell Pharmacol , vol.1 , pp. 44-56
    • Dancea, H.C.1    Shareef, M.M.2    Ahmed, M.M.3
  • 15
    • 41349084565 scopus 로고    scopus 로고
    • Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes
    • Dash R, Mandal M, Ghosh SK, Kundu SC. 2008. Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes. Mol Cell Biochem 311:111-119.
    • (2008) Mol Cell Biochem , vol.311 , pp. 111-119
    • Dash, R.1    Mandal, M.2    Ghosh, S.K.3    Kundu, S.C.4
  • 16
    • 0029826227 scopus 로고    scopus 로고
    • Single-agent paclitaxel as first-line treatment of metastatic breast cancer: The British experience
    • Davidson NG. 1996. Single-agent paclitaxel as first-line treatment of metastatic breast cancer: The British experience. Semin Oncol 23:6-10.
    • (1996) Semin Oncol , vol.23 , pp. 6-10
    • Davidson, N.G.1
  • 17
  • 18
    • 80054784515 scopus 로고    scopus 로고
    • The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer
    • Dhasarathy A, Phadke D, Mav D, Shah RR, Wade PA. 2011. The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS One 6:e26514.
    • (2011) PLoS One , vol.6 , pp. e26514
    • Dhasarathy, A.1    Phadke, D.2    Mav, D.3    Shah, R.R.4    Wade, P.A.5
  • 19
    • 79959526395 scopus 로고    scopus 로고
    • TGF-beta signaling in breast cancer cell invasion and bone metastasis
    • Drabsch Y, ten Dijke P. 2011. TGF-beta signaling in breast cancer cell invasion and bone metastasis. J Mammary Gland Biol Neoplasia 16:97-108.
    • (2011) J Mammary Gland Biol Neoplasia , vol.16 , pp. 97-108
    • Drabsch, Y.1    ten Dijke, P.2
  • 20
    • 84861682542 scopus 로고    scopus 로고
    • Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis
    • Fang Y, DeMarco VG, Nicholl MB. 2012. Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci 103:1090-1098.
    • (2012) Cancer Sci , vol.103 , pp. 1090-1098
    • Fang, Y.1    DeMarco, V.G.2    Nicholl, M.B.3
  • 22
    • 26444509833 scopus 로고    scopus 로고
    • Protection of DNA and membrane from gamma radiation induced damage by gallic acid
    • Gandhi NM, Nair CK. 2005. Protection of DNA and membrane from gamma radiation induced damage by gallic acid. Mol Cell Biochem 278:111-117.
    • (2005) Mol Cell Biochem , vol.278 , pp. 111-117
    • Gandhi, N.M.1    Nair, C.K.2
  • 24
    • 34748812509 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and tumour invasion
    • Guarino M. 2007. Epithelial-mesenchymal transition and tumour invasion. Int J Biochem Cell Biol 39:2153-2160.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 2153-2160
    • Guarino, M.1
  • 26
    • 1442287490 scopus 로고    scopus 로고
    • Radiation therapy for metastatic brain tumors from lung cancer-A review to devise individualized treatment plans
    • Itoh Y, Fuwa N, Morita K. 2003. Radiation therapy for metastatic brain tumors from lung cancer-A review to devise individualized treatment plans. Nagoya J Med Sci 66:119-128.
    • (2003) Nagoya J Med Sci , vol.66 , pp. 119-128
    • Itoh, Y.1    Fuwa, N.2    Morita, K.3
  • 27
    • 42449117212 scopus 로고    scopus 로고
    • The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway
    • Javvadi P, Segan AT, Tuttle SW, Koumenis C. 2008. The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. Mol Pharmacol 73:1491-1501.
    • (2008) Mol Pharmacol , vol.73 , pp. 1491-1501
    • Javvadi, P.1    Segan, A.T.2    Tuttle, S.W.3    Koumenis, C.4
  • 30
    • 84878376817 scopus 로고    scopus 로고
    • Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling
    • Kumar BN, Rajput S, Dey KK, Parekh A, Das S, Mazumdar A, Mandal M. 2013. Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling. BMC Cancer 13:273.
    • (2013) BMC Cancer , vol.13 , pp. 273
    • Kumar, B.N.1    Rajput, S.2    Dey, K.K.3    Parekh, A.4    Das, S.5    Mazumdar, A.6    Mandal, M.7
  • 31
    • 0345328280 scopus 로고    scopus 로고
    • Genistein treatment protects mice from ionizing radiation injury
    • Landauer MR, Srinivasan V, Seed TM. 2003. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol 23:379-385.
    • (2003) J Appl Toxicol , vol.23 , pp. 379-385
    • Landauer, M.R.1    Srinivasan, V.2    Seed, T.M.3
  • 32
    • 84872852680 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition
    • Lv ZD, Kong B, Li JG, Qu HL, Wang XG, Cao WH, Liu XY, Wang Y, Yang ZC, Xu HM, Wang HB. 2013. Transforming growth factor-beta 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition. Oncol Rep 29:219-225.
    • (2013) Oncol Rep , vol.29 , pp. 219-225
    • Lv, Z.D.1    Kong, B.2    Li, J.G.3    Qu, H.L.4    Wang, X.G.5    Cao, W.H.6    Liu, X.Y.7    Wang, Y.8    Yang, Z.C.9    Xu, H.M.10    Wang, H.B.11
  • 33
    • 34147161209 scopus 로고    scopus 로고
    • Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)
    • Murphy DA, Makonnen S, Lassoued W, Feldman MD, Carter C, Lee WMF. 2006. Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006). Am J Pathol 169:1875-1885.
    • (2006) Am J Pathol , vol.169 , pp. 1875-1885
    • Murphy, D.A.1    Makonnen, S.2    Lassoued, W.3    Feldman, M.D.4    Carter, C.5    Lee, W.M.F.6
  • 36
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N. 1997. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 57:4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 37
    • 84887098861 scopus 로고    scopus 로고
    • Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells
    • Rajput S, Kumar BN, Dey KK, Pal I, Parekh A, Mandal M. 2013a. Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. Life Sci 93:783-790.
    • (2013) Life Sci , vol.93 , pp. 783-790
    • Rajput, S.1    Kumar, B.N.2    Dey, K.K.3    Pal, I.4    Parekh, A.5    Mandal, M.6
  • 39
    • 84858290396 scopus 로고    scopus 로고
    • Antitumor promoting potential of selected phytochemicals derived from spices: A review
    • Rajput S, Mandal M. 2012. Antitumor promoting potential of selected phytochemicals derived from spices: A review. Eur J Cancer Prev 21:205-215.
    • (2012) Eur J Cancer Prev , vol.21 , pp. 205-215
    • Rajput, S.1    Mandal, M.2
  • 40
    • 79959328317 scopus 로고    scopus 로고
    • Radiation-induced modifications of the tumor microenvironment promote metastasis
    • Ruegg C, Monnier Y, Kuonen F, Imaizumi N. 2011. Radiation-induced modifications of the tumor microenvironment promote metastasis. Bull Cancer 98:47-57.
    • (2011) Bull Cancer , vol.98 , pp. 47-57
    • Ruegg, C.1    Monnier, Y.2    Kuonen, F.3    Imaizumi, N.4
  • 41
    • 84884396659 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
    • Samatov TR, Tonevitsky AG, Schumacher U. 2013. Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds. Mol Cancer 12:107.
    • (2013) Mol Cancer , vol.12 , pp. 107
    • Samatov, T.R.1    Tonevitsky, A.G.2    Schumacher, U.3
  • 42
    • 77953702943 scopus 로고    scopus 로고
    • ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells
    • Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, Mandal M. 2010. ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer Biol Ther 9:592-603.
    • (2010) Cancer Biol Ther , vol.9 , pp. 592-603
    • Sarkar, S.1    Mazumdar, A.2    Dash, R.3    Sarkar, D.4    Fisher, P.B.5    Mandal, M.6
  • 43
    • 78649651308 scopus 로고    scopus 로고
    • ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells
    • Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, Mandal M. 2011. ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells. J Cell Physiol 226:375-384.
    • (2011) J Cell Physiol , vol.226 , pp. 375-384
    • Sarkar, S.1    Mazumdar, A.2    Dash, R.3    Sarkar, D.4    Fisher, P.B.5    Mandal, M.6
  • 44
    • 79960075594 scopus 로고    scopus 로고
    • Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells
    • Sehrawat A, Singh SV. 2011. Benzyl isothiocyanate inhibits epithelial-mesenchymal transition in cultured and xenografted human breast cancer cells. Cancer Prev Res (Phila) 4:1107-1117.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 1107-1117
    • Sehrawat, A.1    Singh, S.V.2
  • 45
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • Sethi G, Ahn KS, Aggarwal BB. 2008. Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res 6:1059-1070.
    • (2008) Mol Cancer Res , vol.6 , pp. 1059-1070
    • Sethi, G.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 46
    • 0012980550 scopus 로고    scopus 로고
    • In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone
    • Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, Tithof PK. 2003. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 22:107-113.
    • (2003) Int J Oncol , vol.22 , pp. 107-113
    • Shoieb, A.M.1    Elgayyar, M.2    Dudrick, P.S.3    Bell, J.L.4    Tithof, P.K.5
  • 47
    • 84883106837 scopus 로고    scopus 로고
    • Radiation treatments after breast-conserving therapy for elderly patients
    • Smith BD, Buchholz TA. 2013. Radiation treatments after breast-conserving therapy for elderly patients. J Clin Oncol 31:2367-2368.
    • (2013) J Clin Oncol , vol.31 , pp. 2367-2368
    • Smith, B.D.1    Buchholz, T.A.2
  • 49
    • 36048996013 scopus 로고    scopus 로고
    • Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner
    • Vellon L, Menendez JA, Liu H, Lupu R. 2007. Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner. Differentiation 75:819-830.
    • (2007) Differentiation , vol.75 , pp. 819-830
    • Vellon, L.1    Menendez, J.A.2    Liu, H.3    Lupu, R.4
  • 52
    • 51049120763 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    • Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, Wang Y, Sethi G, Aggarwal BB, Liu M. 2008. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Cancer Ther 7:1789-1796.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1789-1796
    • Yi, T.1    Cho, S.G.2    Yi, Z.3    Pang, X.4    Rodriguez, M.5    Wang, Y.6    Sethi, G.7    Aggarwal, B.B.8    Liu, M.9
  • 53
    • 84875044136 scopus 로고    scopus 로고
    • Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors
    • Zhang X, Li Y, Zhang Y, Song J, Wang Q, Zheng L, Liu D. 2013. Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors. PLoS One 8:e58719.
    • (2013) PLoS One , vol.8 , pp. e58719
    • Zhang, X.1    Li, Y.2    Zhang, Y.3    Song, J.4    Wang, Q.5    Zheng, L.6    Liu, D.7
  • 54
    • 80051798242 scopus 로고    scopus 로고
    • Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition
    • Zhang X, Li X, Zhang N, Yang Q, Moran MS. 2011. Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition. Biochem Biophys Res Commun 412:188-192.
    • (2011) Biochem Biophys Res Commun , vol.412 , pp. 188-192
    • Zhang, X.1    Li, X.2    Zhang, N.3    Yang, Q.4    Moran, M.S.5


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