Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition

Biochemical and Biophysical Research Communications

Volumn 412, Issue 1, 2011, Pages 188-192

  Zhang, Xin ^a   Li, Xiaoyan ^a   Zhang, Ning ^a   Yang, Qifeng ^a   Moran, Meena S ^b  

^a SHANDONG UNIVERSITY   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Epithelial mesenchymal transition; Invasion; Ionizing radiation

Indexed keywords

UVOMORULIN; VIMENTIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INVASION; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CELL STRAIN MCF 7; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; IONIZING RADIATION; LOW DOSE IONIZING IRRADIATION; LOW ENERGY RADIATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACTINS; BREAST NEOPLASMS; CADHERINS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, RADIATION; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GAMMA RAYS; HUMANS; NEOPLASM INVASIVENESS; UP-REGULATION; VIMENTIN;

EID: 80051798242     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.07.074     Document Type: Article

References (29)

1. Gluck S., Mamounas T. Improving outcomes in early-stage breast cancer. Oncology (Williston Park) 2010, 24:1-15.
2. Mai G.T., Choo E., Yang J.L., et al. Regional radiotherapy may improve outcomes in patients with early stage breast cancer undergoing breast conservation therapy. Anticancer Res. 2007, 27:647-652.
3. Qiao X.Y., Song Y.Z., Geng C.Z., Gao W., Li C.X., Zhou Z.G. The value of radiotherapy in patients with T1 and T2 breast cancer with one to three positive nodes after modified radical mastectomy. Chin. J. Cancer 2010, 29:436-440.
4. But-Hadzic J., Bilban-Jakopin C., Hadzic V. The role of radiation therapy in locally advanced breast cancer. Breast J. 2010, 16:183-188.
5. Barcellos-Hoff M.H., Park C., Wright E.G. Radiation and the microenvironment - tumorigenesis and therapy. Nat. Rev. Cancer 2005, 5:867-875.
6. Madani I., De Neve W., Mareel M. Does ionizing radiation stimulate cancer invasion and metastasis?. Bull. Cancer 2008, 95:292-300.
7. Gartel A.L., Sofia I., Martins L.R., et al. Low Doses of Ionizing Radiation Promote Tumor Growth and Metastasis by Enhancing Angiogenesis. PLoS ONE 2010, 5:e11222.
8. de Gonzalez A.B., Curtis R.E., Kry S.F., et al. Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries. Lancet Oncol. 2011, 12:353-360.
9. Paquette B., Baptiste C., Therriault H., Arguin G., Plouffe B., Lemay R. In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells. Br. J. Cancer 2007, 97:1505-1512.
10. Huber M.A., Kraut N., Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 2005, 17:548-558.
11. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2002, 2:442-454.
12. Kang Y., Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004, 118:277-279.
13. Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
14. Li X., Kong X., Huo Q., et al. Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci. 2011.
15. Olmeda D., Jorda M., Peinado H., Fabra A., Cano A. Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene 2007, 26:1862-1874.
16. Phinney D.G. Twist EMT and Stem Cells. Stem Cells 2010.
17. Barrett S.V. Breast cancer. J. R. Coll. Physicians Edinb quiz 2010, 40(339):335-338.
18. Gonzalez-Angulo A.M., Morales-Vasquez F., Hortobagyi G.N. Overview of resistance to systemic therapy in patients with breast cancer. Adv. Exp. Med. Biol. 2007, 608:1-22.
19. Berx G., Raspe E., Christofori G., Thiery J.P., Sleeman J.P. Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clin. Exp. Metastasis 2007, 24:587-597.
20. Zeisberg M., Neilson E.G. Biomarkers for epithelial-mesenchymal transitions. J. Clin. Invest. 2009, 119:1429-1437.
21. Creighton C.J., Chang J.C., Rosen J.M. Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. J. Mammary Gland Biol. Neoplasia 2010, 15:253-260.
22. Kurrey N.K., Jalgaonkar S.P., Joglekar A.V., et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009, 27:2059-2068.
23. Escriva M., Peiro S., Herranz N., et al. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol. Cell. Biol. 2008, 28:1528-1540.
24. Moody S.E., Perez D., Pan T.C., et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 2005, 8:197-209.
25. Yang J., Mani S.A., Donaher J.L., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 117:927-939.
26. Zhou B.P., Deng J., Xia W., et al. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 2004, 6:931-940.
27. Hayashida T., Jinno H., Kitagawa Y., Kitajima M. Cooperation of Cancer Stem Cell Properties and Epithelial-Mesenchymal Transition in the Establishment of Breast Cancer Metastasis. J. Oncol. 2011, 2011:1-7.
28. Yang J., Weinberg R.A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell 2008, 14:818-829.
29. Hugo H., Ackland M.L., Blick T., et al. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J. Cell. Physiol. 2007, 213:374-383.