Beta-Elemene Blocks Epithelial-Mesenchymal Transition in Human Breast Cancer Cell Line MCF-7 through Smad3-Mediated Down-Regulation of Nuclear Transcription Factors

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Zhang, Xian ^a   Li, Yinghua ^a   Zhang, Yang ^a   Song, Jincheng ^a   Wang, Qimin ^a   Zheng, Luping ^a   Liu, Dan ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ELEMENE; MESSENGER RNA; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SIP1; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; BASAL LIKE BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL INVASION; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MIGRATION INHIBITION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL MOVEMENT; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MCF-7 CELLS; NEOPLASM INVASIVENESS; PHENOTYPE; PHOSPHORYLATION; SESQUITERPENES; SNRNP CORE PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84875044136     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058719     Document Type: Article

References (51)

1. Siegel R, Naishadham D, Jemal A, (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29.
2. DeSantis C, Siegel R, Bandi P, Jemal A, (2011) Breast cancer statistics, 2011. CA Cancer J Clin 61: 409-418.
3. Meyer T, Hart IR, (1998) Mechanisms of tumour metastasis. Eur J Cancer 34: 214-221.
4. Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
5. Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, et al. (2008) Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 68: 937-945.
6. Foroni C, Broggini M, Generali D, Damia G, (2012) Epithelial-mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact. Cancer Treat Rev 38: 689-697.
7. Li QQ, Xu JD, Wang WJ, Cao XX, Chen Q, et al. (2009) Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells. Clin Cancer Res 15: 2657-2665.
8. Chen J, Imanaka N, Griffin JD, (2010) Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer 102: 351-360.
9. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
10. Giordano A, Gao H, Anfossi S, Cohen E, Mego M, et al. (2012) Epithelial-Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer. Mol Cancer Ther.
11. Dave B, Mittal V, Tan NM, Chang JC, (2012) Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Res 14: 202.
12. Kasimir-Bauer S, Hoffmann O, Wallwiener D, Kimmig R, Fehm T, (2012) Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells. Breast Cancer Res 14: R15.
13. Tse JC, Kalluri R, (2007) Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem 101: 816-829.
14. Zavadil J, Bottinger EP, (2005) TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-5774.
15. Massague J, (2008) TGFbeta in Cancer. Cell 134: 215-230.
16. Drasin DJ, Robin TP, Ford HL, (2011) Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity. Breast Cancer Res 13: 226.
17. de Herreros AG, Peiro S, Nassour M, Savagner P, (2010) Snail family regulation and epithelial mesenchymal transitions in breast cancer progression. J Mammary Gland Biol Neoplasia 15: 135-147.
18. Dhasarathy A, Phadke D, Mav D, Shah RR, Wade PA, (2011) The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS One 6: e26514.
19. Kang Y, Massague J, (2004) Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277-279.
20. Huber MA, Kraut N, Beug H, (2005) Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17: 548-558.
21. Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, et al. (2004) NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 114: 569-581.
22. Hsu HY, Lin TY, Hwang PA, Chen RH, Tsao SM, et al. (2012) Fucoidan induces changes in the epithelial-mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFbeta receptor degradation in breast cancer. Carcinogenesis.
23. Sehrawat A, Kim SH, Vogt A, Singh SV (2012) Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells. Carcinogenesis.
24. Huang T, Chen Z, Fang L, (2013) Curcumin inhibits LPS-induced EMT through downregulation of NF-kappaB-Snail signaling in breast cancer cells. Oncol Rep 29: 117-124.
25. Ismail IA, Kang HS, Lee HJ, Chang H, Yun J, et al. (2013) 2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells. Breast Cancer Res Treat.
26. Lu JJ, Dang YY, Huang M, Xu WS, Chen XP, et al. (2012) Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review. J Ethnopharmacol.
27. Wang G, Li X, Huang F, Zhao J, Ding H, et al. (2005) Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci 62: 881-893.
28. Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, et al. (2008) Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett 264: 127-134.
29. Liu J, Zhang Y, Qu J, Xu L, Hou K, et al. (2011) beta-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis. BMC Cancer 11: 183.
30. Li X, Wang G, Zhao J, Ding H, Cunningham C, et al. (2005) Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci 62: 894-904.
31. Liu J, Hu XJ, Jin B, Qu XJ, Hou KZ, et al. (2012) beta-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells. J Pharm Pharmacol 64: 146-153.
32. Chen X, Wang Y, Luo H, Luo Z, Zhang T, et al. (2012) beta-elemene acts as an antitumor factor and downregulates the expression of survivin, Bcl-xL and Mta-1. Mol Med Report.
33. Zhao YS, Zhu TZ, Chen YW, Yao YQ, Wu CM, et al. (2012) Beta-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells. J Neurooncol 107: 307-314.
34. Li L, Xu L, Qu X, Zhao M, Yu P, et al. (2011) Cbl-regulated Akt and ERK signals are involved in beta-elemene-induced cell apoptosis in lung cancer cells. Mol Med Report 4: 1243-1246.
35. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, et al. (2001) Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 12: 27-36.
36. Drabsch Y, Ten Dijke P (2012) TGF-beta signalling and its role in cancer progression and metastasis. Cancer Metastasis Rev.
37. Roberts AB, Tian F, Byfield SD, Stuelten C, Ooshima A, et al. (2006) Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev 17: 19-27.
38. Tarasewicz E, Jeruss JS, (2012) Phospho-specific Smad3 signaling: Impact on breast oncogenesis. Cell Cycle 11: 2443-2451.
39. Coradini D, Fornili M, Ambrogi F, Boracchi P, Biganzoli E, (2012) TP53 mutation, epithelial-mesenchymal transition, and stemlike features in breast cancer subtypes. J Biomed Biotechnol 2012: 254085.
40. Gal A, Sjoblom T, Fedorova L, Imreh S, Beug H, et al. (2008) Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene 27: 1218-1230.
41. Parvani JG, Taylor MA, Schiemann WP, (2011) Noncanonical TGF-beta signaling during mammary tumorigenesis. J Mammary Gland Biol Neoplasia 16: 127-146.
42. Xu J, Lamouille S, Derynck R, (2009) TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172.
43. Fransvea E, Angelotti U, Antonaci S, Giannelli G, (2008) Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 47: 1557-1566.
44. Anido J, Saez-Borderias A, Gonzalez-Junca A, Rodon L, Folch G, et al. (2010) TGF-beta Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma. Cancer Cell 18: 655-668.
45. Tran DD, Corsa CA, Biswas H, Aft RL, Longmore GD, (2011) Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence. Mol Cancer Res 9: 1644-1657.
46. Medici D, Hay ED, Goodenough DA, (2006) Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell 17: 1871-1879.
47. Castro Alves C, Rosivatz E, Schott C, Hollweck R, Becker I, et al. (2007) Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin. J Pathol 211: 507-515.
48. Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y, (2009) Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15: 195-206.
49. Zhang B, Zhang X, Tang B, Zheng P, Zhang Y, (2012) Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor alpha (ERalpha) re-expression. Breast Cancer Res Treat 136: 399-406.
50. Guttilla IK, Adams BD, White BA, (2012) ERalpha, microRNAs, and the epithelial-mesenchymal transition in breast cancer. Trends Endocrinol Metab 23: 73-82.
51. Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, et al. (2010) Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradation. J Biol Chem 285: 14747-14755.