Lung burden and deposition distribution of inhaled atmospheric urban ultrafine particles as the first step in their health risk assessment

Atmospheric Environment

Volumn 104, Issue , 2015, Pages 39-49

  Salma, Imre ^a   Füri, Péter ^b   Németh, Zoltán ^a   Balásházy, Imre ^b   Hofmann, Werner ^c   Farkas, Árpád ^b  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Exposure assessment; Nanoaerosol; Respiratory deposition; Stochastic lung deposition model; Surface density deposition

Indexed keywords

BIOLOGICAL ORGANS; DEPOSITION RATES; HEALTH RISKS; RISK ASSESSMENT; SLEEP RESEARCH; STOCHASTIC MODELS; STOCHASTIC SYSTEMS; URBAN PLANNING;

DEPOSITION DISTRIBUTION; DIFFERENTIAL MOBILITY PARTICLE SIZER; EXPOSURE ASSESSMENT; LUNG DEPOSITIONS; NANOAEROSOL; PARTICLE NUMBER SIZE DISTRIBUTION; SURFACE DENSITY; TRACHEOBRONCHIAL REGION;

DEPOSITION;

AEROSOL COMPOSITION; ATMOSPHERIC DEPOSITION; ATMOSPHERIC POLLUTION; HEALTH RISK; PARTICLE SIZE; POLLUTION EXPOSURE; PUBLIC HEALTH; RESPIRATORY DISEASE; RISK ASSESSMENT; SIZE DISTRIBUTION;

ADULT; AEROSOL; AIRWAY; ARTICLE; ATMOSPHERE; BREATHING EXERCISE; CASE REPORT; DENSITY; FEMALE; HEALTH HAZARD; HUMAN; HUMIDITY; INHALATION; LUNG BURDEN; LUNG VENTILATION; NORMAL HUMAN; PARTICLE SIZE; PARTICULATE MATTER; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SITTING; SLEEP; SURFACE PROPERTY; URBAN AREA;

BUDAPEST; HUNGARY;

EID: 84920868011     PISSN: 13522310     EISSN: 18732844     Source Type: Journal    
DOI: 10.1016/j.atmosenv.2014.12.060     Document Type: Article

References (53)

1. Aalto P., Hämeri K., Paatero P., Kulmala M., Bellander T., Berglind N., Bouso L., Castaño-Vinyals G., Sunyer J., Cattani G., Marconi A., Cyrys J., von Klot S., Peters A., Zetzsche K., Lanki T., Pekkanen J., Nyberg F., Sjövall B., Forastiere F. Aerosol particle number concentration measurements in five European cities using TSI-3022 condensation particle counter over a three-year period during health effects of air pollution on susceptible subpopulations. J.Air Waste Manag. Assoc. 2005, 55:1064-1076.
2. Asgharian B., Ménache M.G., Miller F.J. Modeling age-related particle deposition in humans. J.Aerosol Med. 2004, 17:213-224.
3. Asgharian B., Price O., Miller F., Subramaniam R., Cassee F.R., Freijer J., van Bree L., Winter-Sorkina R. Multiple-path Particle Dosimetry Model (MPPD v. 2.11): a Model for Human and Rat Airway Particle Dosimetry 2009, Applied Research Associates, Hamner Institutes for Health Sciences, National Institute for Public Health and the Environment, and Ministry of Housing, Spatial Planning and the Environment, Raleigh, North Carolina, USA.
4. Avino P., Casciardi S., Fanizza C., Manigrasso M. Deep investigation of ultrafine particles in urban air. Aerosol Air Qual. Res. 2011, 11:654-663.
5. Balásházy I., Hofmann W. Quantification of local deposition patterns of inhaled radon decay products in human bronchial airway bifurcations. Health Phys. 2000, 78:147-158.
6. Balásházy I., Hofmann W., Heistracher T. Local particle deposition patterns may play a key role in the development of lung cancer. J.App. Physiol. 2003, 94:1719-1725.
7. Balásházy I., Alföldy B., Molnár A.J., Hofmann W., Szoke I., Kis E. Aerosol drug delivery optimization by computational methods for the characterization of total and regional deposition of therapeutic aerosols in the respiratory system. Curr. Computer-Aided Drug Des. 2007, 3:13-32.
8. Balásházy I., Farkas Á., Madas B.G., Hofmann W. Non-linear relationship of cell hit and transformation probabilities in low dose of inhaled radon progenies. J.Radiol. Prot. 2009, 29:147-162.
9. Borsós T., Řimnáčová D., Ždímal V., Smolík J., Wagner Z., Weidinger T., Burkart J., Steiner G., Reischl G., Hitzenberger R., Schwarz J., Salma I. Comparison of particulate number concentrations in three Central European capital cities. Sci. Total Environ. 2012, 433:418-426.
10. Braakhuis H.M., Park M.V., Gosens I., De Jong W.H., Cassee F.R. Physicochemical characteristics of nanomaterials that affect pulmonary inflammation. Part Fibre Toxicol. 2014, 11:18. 10.1186/1743-8977-11-18.
11. Carvalho T.C., Peters J.I., Williams R.O. Influence of particle size on regional lung deposition-what evidence is there?. Int. J. Pharm. 2011, 406:1-10.
12. Dall'Osto M., Querol X., Alastuey A., O'Dowd C., Harrison R.M., Wenger J., Gómez-Moreno F.J. On the spatial distribution and evolution of ultrafine particles in Barcelona. Atmos. Chem. Phys. 2013, 13:741-759.
13. DeCarlo P.F., Slowik J.G., Worsnop D.R., Davidovits P., Jimenez J.L. Particle morphology and density characterization by combined mobility and aerodynamic diameter measurements. Part 1: Theory. Aerosol Sci. Technol. 2004, 38:1185-1205.
14. Giechaskiel B., Alföldy B., Drossinos Y. Ametric for health effects studies of diesel exhaust particles. J.Aerosol Sci. 2009, 40:639-651.
15. Geiser M., Rothen-Rutishauser B., Kapp N., Schürch S., Kreyling W., Schulz H., Semmler M., Im Hof V., Heyder J., Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 2005, 113:1555-1560.
16. Geiser M., Casaulta M., Kupferschmid B., Schulz H., Semmler-Behnke M., Kreyling W. The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles. Am. J. Respir. Cell. Mol. Biol. 2008, 38:371-376.
17. Haefeli-Bleuer B., Weibel E.R. Morphometry of the human pulmonary acinus. Anat. Rec. 1988, 220:401-414.
18. Harrison R.M., Jones A.M. Multisite study of particulate number concentrations in urban air. Environ. Sci. Technol. 2005, 39:6063-6070.
19. HEI Review Panel on Ultrafine Particles: Understanding the Health Effects of Ambient Ultrafine Particles. HEI Perspectives 3 2013, Health Effects Institute, Boston, MA.
20. Hofmann W., Koblinger L. Monte Carlo modelling of aerosol deposition in human lungs. Part II: deposition fractions and their sensitivity to parameter variations. J.Aerosol Sci. 1990, 21:675-688.
21. Hofmann W., Koblinger L. Monte Carlo modelling of aerosol deposition in human lungs. Part III: comparison with experimental data. J.Aerosol Sci. 1992, 23:51-63.
22. Hofmann W. Modelling inhaled particle deposition in the human lung - a review. J.Aerosol Sci. 2011, 42:693-724.
23. International Commission on Radiological Protection (ICRP) Human respiratory tract model for radiological protection. Ann. ICRP 1994, 24. Publication 66.
24. Jeong C.-H., Evans G.J., Hopke P.K., Chalupa D., Utell M.J. Influence of atmospheric dispersion and new particle formation events on ambient particle number concentration in Rochester, United States, and Toronto, Canada. J.Air Waste Manage Assoc. 2006, 56:431-443.
25. Khlystov A., Stanier C., Pandis S.N. An algorithm for combining electrical mobility and aerodynamic size distributions data when measuring ambient aerosol. Aerosol Sci. Technol. 2004, 38:229-238.
26. Koblinger L., Hofmann W. Monte Carlo modeling of aerosol deposition in human lungs. Part I: simulation of particle transport in a stochastic lung structure. J.Aerosol Sci. 1990, 21:661-674.
27. Kreyling W.G., Semmler M., Erbe F., Mayer P., Takenaka S., Schulz H., Oberdörster G., Ziesenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J.Toxicol. Environ. Health A 2002, 65:1513-1530.
28. Kreyling W.G., Semmler-Behnke M., Möller W. Ultrafine particle-lung interactions: does size matter?. J.Aerosol Med. 2006, 19:74-83.
29. Krol S., MacRez R., Docagne F., Defer G., Laurent S., Rahman M., Hajipour M.J., Kehoe P.G., Mahmoudi M. Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier. Chem. Rev. 2013, 113:1877-1903.
30. Kulmala M., Vehkamäki H., Petäjä T., Dal Maso M., Lauri A., Kerminen V.-M., Birmili W., McMurry P. Formation and growth rates of ultrafine atmospheric particles: a review of observations. J.Aerosol Sci. 2004, 35:143-176.
31. Ménache M.G., Hofmann W., Asgharian B., Miller F.J. Airway geometry: models of children's lungs for use in dosimetry modeling. Inhal. Toxicol. 2008, 20:101-126.
32. Nel A., Xia T., Mädler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
33. Oberdörster G., Oberdörster E., Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005, 113:823-839.
34. Ondráček J., Ždímal V., Smolík J., Lazaridis M. Amerging algorithm for aerosol size distribution from multiple instruments. Water Air Soil Pollut. 2009, 199:219-233.
35. Park K., Kittelson D.B., Zachariah M.R., McMurry P.H. Measurement of inherent material density of nanoparticle agglomerates. J.Nanopart Res. 2004, 6:267-272.
36. Putaud J.-P., Van Dingenen R., Alastuey A., Bauer H., Birmili W., Cyrys J., Flentje H., Fuzzi S., Gehrig R., Hansson H.C., Harrison R.M., Herrmann H., Hitzenberger R., Hüglin C., Jones A.M., Kasper-Giebl A., Kiss G., Kousa A., Kuhlbusch T.A.J., Löschau G., Maenhaut W., Molnár A., Moreno T., Pekkanen J., Perrino C., Pitz M., Puxbaum H., Querol X., Rodriguez S., Salma I., Schwarz J., Smolik J., Schneider J., Spindler G., ten Brink H., Tursic J., Viana M., Wiedensohler A., Raes F. An European aerosol phenomenology - 3: physical and chemical characteristics of particulate matter from 60 rural, urban, and kerbside sites across Europe. Atmos. Environ. 2010, 44:1308-1320.
37. Qian S., Sakurai H., McMurry P.H. Characteristics of regional nucleation events in urban East St. Louis. Atmos. Environ. 2007, 41:4119-4127.
38. Raabe O.G., Yeh H.-C., Schum G.M., Phalen R.F. Tracheo-bronchial Geometry: Human, Dog, Rat, Hamster - a Compilation of Selected Data from the Project Respiratory Tract Deposition Models 1976, Report LF-53, Lovelace Foundation, Albuquerque, NM.
39. Reche C., Querol X., Alastuey A., Viana M., Pey J., Moreno T., Rodríguez S., González Y., Fernández-Camacho R., de la Rosa J., Dall'Osto M., PrévÔt A.S.H., Hueglin C., Harrison R.M., Quincey P. New considerations for PM, Black Carbon and particle number concentration for air quality monitoring across different European cities. Atmos. Chem. Phys. 2011, 11:6207-6227.
40. Rissler J., Messing M.E., Malik A.I., Nilsson P.T., Nordin E.Z., Bohgard M., Sanati M., Pagels J.H. Effective density characterization of soot agglomerates from various sources and comparison to aggregation theory. Aerosol Sci. Technol. 2013, 47:792-805.
41. Rodríguez S., Van Dingenen R., Putaud J.-P., Dell'Acqua A., Pey J., Querol X., Alastuey A., Chenery S., Ho K.-F., Harrison R.M., Tardivo R., Scarnato B., Gemelli V. Astudy on the relationship between mass concentrations, chemistry and number size distribution of urban fine aerosols in Milan, Barcelona and London. Atmos. Chem. Phys. 2007, 7:2217-2232.
42. Salma I., Balásházy I., Winkler-Heil R., Hofmann W., Záray G.Y. Effect of particle mass size distribution on the deposition of aerosols in the human respiratory system. J.Aerosol Sci. 2002, 33:119-132.
43. Salma I., Balásházy I., Hofmann W., Záray G.Y. Effect of physical exertion on the deposition of urban aerosols in the human respiratory system. J.Aerosol Sci. 2002, 33:983-997.
44. Salma I., Borsós T., Weidinger T., Aalto P., Hussein T., Dal Maso M., Kulmala M. Production, growth and properties of ultrafine atmospheric aerosol particles in an urban environment. Atmos. Chem. Phys. 2011, 11:1339-1353.
45. Salma I., Borsós T., Aalto P.P., Kulmala M. Time-resolved number concentration and size distribution of aerosol particles in an urban road tunnel. Boreal Environ. Res. 2011, 16:262-272.
46. Salma I., Borsós T., Németh Z., Weidinger T., Aalto P., Kulmala M. Comparative study of ultrafine atmospheric aerosol within a city. Atmos. Environ. 2014, 92:154-161.
47. Stöber W., Morrow P.E., Koch W., Morawietz G. Alveolar clearance and retention of inhaled insoluble particles in rats simulated by a model inferring macrophage particle load distribution. J.Aerosol Sci. 1994, 25:975-1002.
48. Varghese S.K., Gangamma S. Particle deposition in human respiratory system: deposition of concentrated hygroscopic aerosols. Inhal. Toxicol. 2009, 21:619-630.
49. Wehner B., Wiedensohler A. Long term measurements of submicrometer urban aerosols: statistical analysis for correlations with meteorological conditions and trace gases. Atmos. Chem. Phys. 2003, 3:867-879.
50. Wiedensohler A., Birmili W., Nowak A., Sonntag A., Weinhold K., Merkel M., Wehner B., Tuch T., Pfeifer S., Fiebig M., Fjäraa A.M., Asmi E., Sellegri K., Depuy R., Venzac H., Villani P., Laj P., Aalto P., Ogren J.A., Swietlicki E., Williams P., Roldin P., Quincey P., Hüglin C., Fierz-Schmidhauser R., Gysel M., Weingartner E., Riccobono F., Santos S., Grüning C., Faloon K., Beddows D., Harrison R., Monahan C., Jennings S.G., O'Dowd C.D., Marinoni A., Horn H.-G., Keck L., Jiang J., Scheckman J., McMurry P.H., Deng Z., Zhao C.S., Moerman M., Henzing B., de Leeuw G., Löschau G., Bastian S. Mobility particle size spectrometers: harmonization of technical standards and data structure to facilitate high quality long-term observations of atmospheric particle number size distributions. Atmos. Meas. Tech. 2012, 5:657-685.
51. Winkler-Heil R., Ferron G., Hofmann W. Calculation of hygroscopic particle deposition in the human lung. Inhal. Toxicol. 2014, 26:193-206.
52. World Health Organization (WHO) Effects of Air Pollution on Children's Health and Development 2005, Regional Office for Europe, Bonn.
53. Yang W., Peters J.I., Williams R.O. Inhaled nanoparticles - a current review. Int. J. Pharm. 2008, 356:239-247.