Aerosol drug delivery optimization by computational methods for the characterization of total and regional deposition of therapeutic aerosols in the respiratory system

Current Computer-Aided Drug Design

Volumn 3, Issue 1, 2007, Pages 13-32

  Balásházy, Imre ^a,b   Alföldy, Bálint ^b   Molnár, Andrea J ^a   Hofmann, Werner ^c   Szoke, István ^b   Kis, Erika ^d  

^a Respirisk Scientific Research Co Ltd   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF SALZBURG   (Austria)

^d BABE BOLYAI UNIVERSITY   (Romania)

Author keywords

Aerosol drug delivery optimization; Distribution of deposition in the airways; Optimal inhalation method; Optimal particle size; Respiratory tract models; Stochastic lung deposition model; Therapeutic aerosols

Indexed keywords

AEROSOLS; BIOLOGICAL ORGANS; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED DRUG DELIVERY; DISEASES; PARTICLE SIZE; RESPIRATORY SYSTEM; STOCHASTIC MODELS; STOCHASTIC SYSTEMS; TARGETED DRUG DELIVERY;

AEROSOL DRUG DELIVERY; AEROSOL DRUG DELIVERY OPTIMIZATION; DEPOSITION MODELING; DISTRIBUTION OF DEPOSITION IN THE AIRWAY; LUNG DEPOSITIONS; OPTIMAL INHALATION METHOD; OPTIMAL PARTICLE SIZES; OPTIMISATIONS; RESPIRATORY TRACT; RESPIRATORY TRACT MODEL; STOCHASTIC LUNG DEPOSITION MODEL; STOCHASTICS; THERAPEUTIC AEROSOLS;

DEPOSITION;

BRONCHODILATING AGENT;

AEROSOL; ALLERGY; BREATHING MECHANICS; COMPUTER PROGRAM; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; GEOMETRY; HUMAN; INHALATION SPACER; LUNG DISEASE; MATHEMATICAL COMPUTING; METERED DOSE INHALER; NEBULIZER; PARTICLE SIZE; PARTICULATE MATTER; POROSITY; POWDER INHALER; PROCESS OPTIMIZATION; RESPIRATORY SYSTEM; REVIEW; STOCHASTIC MODEL;

EID: 33947151893     PISSN: 15734099     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340907780058727     Document Type: Review

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