Calculation of hygroscopic particle deposition in the human lung

Inhalation Toxicology

Volumn 26, Issue 3, 2014, Pages 193-206

  Winkler Heil, Renate ^a   Ferron, George ^b   Hofmann, Werner ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Human lung; Hygroscopic growth; Particle deposition

Indexed keywords

ABSORPTION; AEROSOLS; AIR POLLUTANTS; COBALT; HUMANS; INHALATION EXPOSURE; LUNG; MODELS, BIOLOGICAL; PARTICULATE MATTER; SODIUM CHLORIDE; STOCHASTIC PROCESSES; TISSUE DISTRIBUTION; WATER; ZINC SULFATE;

EID: 84894086240     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2013.876468     Document Type: Article

References (63)

1. Anselm A. (1985). A method to determine the change in size of hygroscopic aerosol particles in the human respiratory tract [master thesis]. Frankfurt/Main: Johann Wolfgang Goethe University (in German
2. Anselm A. (1989). Behaviour of hygroscopic aerosol particles in the human respiratory tract [PhD thesis]. Frankfurt/Main: Johann Wolfgang Goethe University (in German
3. Anselm A, Heibel T, Gebhart J, Ferron G. (1990). ''In vivo''-studies of growth factors of sodium chloride particles in the human respiratory tract. J Aerosol Sci 21:S427
4. Asgharian B. (2004). A model of deposition of hygroscopic particles in the human lung. Aerosol Sci Technol 38:938-47
5. Balásházy I, Hofmann W, Heistracher T. (2003). Local particle deposition patterns may play a key role in the development of lung cancer. J Appl Physiol 94:1719-25
6. Blanchard JD, Willeke K. (1983). An inhalation system for characterizing total lung deposition of ultrafine particles. Am Ind Hyg Ass J 44: 846-56
7. Blanchard JD, Willeke K. (1984). Total deposition of ultrafine sodium chloride particles in the human lungs. J Appl Physiol 57:1850-6
8. Broday DM, Georgopoulos PG. (2001). Growth and deposition of hygroscopic particulate matter in the human lung. Aerosol Sci Technol 34:144-59
9. Budavari S. (1989). Miscellaneous tables. In: Merck index. Rahway, NJ: Merck Co. Inc
10. Cai FS, Yu CP. (1988). Inertial and interceptional deposition of spherical particles and fibers in a bifurcating airway. J Aerosol Sci 19:679-88
11. Chan TL, Schreck RM, Lippmann M. (1980). Effect of the laryngeal jet on particle deposition in the human trachea and upper bronchial airways. J Aerosol Sci 11:447-59
12. Cheng YS. (2003). Aerosol deposition in the extrathoracic region. Aerosol Sci Technol 37:659-71
13. Cohen BS, Asgharian B. (1990). Deposition of ultrafine particles in the upper airways: An empirical analysis. J Aerosol Sci 21:789-97
14. Dautrebande L, Walkenhorst W. (1961). über die Retention von Kochsalzteilchen in den Atemwegen. In: Davies CN. (ed.) Inhaled particles and vapours I. Oxford: Pergamon Press, 110-29
15. Davies CN. (1978). Evaporation of airborne particles. In: Shaw DT. (ed.) Fundamentals of aerosol science. New York: John Wiley & Sons, 135-64
16. Farkas A ́, Balásházy I, Szöcs K. (2006). Characterization of regional and local deposition of inhaled drugs in the respiratory system by computational fluid and particles dynamics methods. J Aerosol Med 19:329-43
17. Ferron GA. (1977). The size of soluble aerosol particles as a function of the humidity of the air: Application to the human respiratory tract. J Aerosol Sci 8:251-67
18. Ferron GA, Soderholm SC. (1990). Estimation of the times for evaporation of pure water droplets and the stabilization times of salt solution particles. J Aerosol Sci 21:415-29
19. Ferron GA, Haider B, Kreyling WG. (1985a). A method for the approximation of the relative humidity in the upper airways. Bull Math Biol 47:565-89
20. Ferron, GA, Hornik S, Kreyling WG, Haider B. (1985b). Comparison of experimental and calculated data for the total and regional deposition in the human lung. J Aerosol Sci 16:133-43
21. Ferron GA, Haider B, Kreyling WG. (1988a). Inhalation of salt aerosol particles I. Estimation of the temperature and relative humidity in the upper human airways. J Aerosol Sci 19:343-63
22. Ferron GA, Kreyling WG, Haider B. (1988b). Inhalation of salt aerosol particles II. Growth and deposition in the human respiratory tract. J Aerosol Sci 19:611-31
23. Ferron GA, Karg E, Peter JE. (1993). Estimation of the deposition of polydisperse hygroscopic aerosols in the human respiratory tract. J Aerosol Sci 24:655-70
24. Ferron GA, Upadhyay S, Zimmermann R, Karg E. (2013). Model of the deposition of aerosol particles in the respiratory tract of the rat. II. Hygroscopic particle deposition. J Aerosol Med Pulm Deliv 26: 101-19
25. Finlay WH. (2001). The mechanics of inhaled pharmaceutical aerosols: An introduction. New York: Academic Press
26. Finlay WH, Lange CF, King M, Speers D. (2000). Lung delivery of aerosolized dextran. Am J Respir Crit Care Med 161:91-7
27. Fuchs NA. (1962). Evaporation and droplet growth in gaseous media. Oxford: Pergamon Press
28. Gebhart J, Anselm A, Ferron G, et al. (1990). Experimental data on total deposition of hygroscopic particles in the human respiratory tract. In: Masuda S, Takahashi K. (eds.) Aerosols: Science, industry, health and environment. Oxford: Pergamon Press, 1299-302
29. Haefeli-Bleuer B, Weibel ER. (1988). Morphometry of the human pulmonary acinus. Anat Rec 220:401-14
30. Heyder J, Gebhart J, Rudolf G, et al. (1986). Deposition of particles in the human respiratory tract in the size range 0.005 to 15 mm. J Aerosol Sci 17:811-25
31. Hofmann W. (2011). Modelling inhaled particle deposition in the human lung-A review. J Aerosol Sci 42:693-724
32. Hofmann W, Koblinger L. (1990). Monte Carlo modeling of aerosol deposition in human lungs. Part II: Deposition fractions and their sensitivity to parameter variations. J Aerosol Sci 21:674-88
33. Hofmann W, Asgharian B, Winkler-Heil R. (2002). Modeling intersubject variability of particle deposition in human lungs. J Aerosol Sci 33:219-35
34. Hofmann W, Sturm R, Fleming JS, et al. (2005). Simulation of threedimensional particle deposition patterns in human lungs and comparison with experimental SPECT data. Aerosol Sci Technol 39: 771-81
35. Hofmann W, Winkler-Heil R, Balásházy I. (2006). The effect of morphological variability on surface deposition densities of inhaled particles in human bronchial and acinar airways. Inhal Toxicol 18: 809-19
36. Hofmann W, Pawlak E, Sturm R. (2008). Semi-empirical stochastic model of aerosol bolus dispersion in the human lung. Inhal Toxicol 20:1059-73
37. Hofmann W, Morawska L, Winkler-Heil R, Moustafa M. (2009). Deposition of combustion aerosols in the human respiratory tract: Comparison of theoretical predictions with experimental data considering nonspherical shape. Inhal Toxicol 21:1154-64
38. Hussain M, Winkler-Heil R, Hofmann W. (2011). Effect of intersubject variability of extrathoracic morphometry, lung airway dimensions and respiratory parameters on particle deposition. J Thorac Dis 3: 156-70
39. Ingham DB. (1975). Diffusion of aerosols from a stream flowing through a cylindrical tube. J Aerosol Sci 6:125-32
40. International Commission on Radiological Protection (ICRP). (1994). Human respiratory tract model for radiological protection. ICRP Publication 66. Ann. ICRP 24, Nos 1-3. Oxford: Pergamon Press
41. Koblinger L, Hofmann W. (1985). Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Phys Med Biol 30:541-56
42. Koblinger L, Hofmann W. (1990). Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure. J Aerosol Sci 21:661-74
43. Lin TC, Breysse PN, Laube B, Swift DL. (2001). Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways. J Aerosol Med 14:335-41
44. Löndahl J, Massling A, Pagels J, et al. (2007). Size-resolved respiratorytract deposition of fine and ultrafine hydrophobic and hygroscopic aerosol particles during rest and exercise. Inhal Toxicol 19:109-16
45. Löndahl J, Möller W, Pagels JH, et al. (2013). Measurement techniques for respiratory tract deposition of airborne nanoparticles: A critical review. J Aerosol Med Pulm Deliv. DOI: 10.1089/jamp.2013.1044
46. Martonen TB. (1982). Analytical model of hygroscopic particle behavior in human airways. Bull Math Biol 44:425-42
47. McFadden Jr. ER, Pichurko BM, Bowman HF, et al. (1985). Thermal mapping of the airways of humans. J Appl Physiol 58:564-70
48. Persons DD, Hess D, Muller WJ, Scherer PW. (1987). Airway deposition of hygroscopic heterodispersed aerosol: Results of a computer calculation. J Appl Physiol 63:1195-204
49. Pruppacher HR, Klett JD. (1980). Microphysics of clouds and precipitation. Dordrecht: Riedel Publishing Company
50. Raabe OG, Yeh HC, Schum GM, Phalen RF. (1976). Tracheobronchial geometry: Human, dog, rat, hamster. Lovelace Foundation Report LF-53. Albuquerque, NM: Lovelace Foundation
51. Robinson RA, Stokes RH. (1968). Electrolyte solutions. London: Butterworth
52. Robinson RJ, Yu CP. (1998). Theoretical analysis of hygroscopic growth rate of mainstream and sidestream cigarette smoke particles in the human respiratory tract. Aerosol Sci Technol 28:21-32
53. Schiller CF, Gebhart J, Heyder J, et al. (1988). Deposition of monodisperse insoluble aerosol particles in the 0.005 to 0.2 mm size range within the human respiratory tract. Ann Occup Hyg Suppl 1:41-9
54. Stapleton KW, Finlay WH, Zuberbuhler P. (1994). An in vitro method for determining regional dosage delivered by jet nebulizers. J Aerosol Med 7:325-44
55. Tu KW, Knutson EO. (1984). Total deposition of ultrafine hydrophobic and hygroscopic aerosols in the human respiratory tract. Aerosol Sci Technol 3:453-65
56. Varghese SK, Gangamma S. (2009). Particle deposition in human respiratory system: Deposition of concentrated hygroscopic aerosols. Inhal Toxicol 21:619-30
57. Wagner PE. (1982). Aerosol growth by condensation. In: Marlow WH. (ed.) Aerosol microphysics II. Berlin: Springer, 129-78
58. Weibel ER. (1963). Morphometry of the human lung. Berlin: Springer
59. Xu GB, Yu CP. (1985). Theoretical lung deposition of hygroscopic NaCl aerosols. Aerosol Sci Technol 4:455-61
60. Yeh HC, Schum GM. (1980). Models of the human lung airways and their application to inhaled particle deposition. Bull Math Biol 42: 461-80
61. Zebel G. (1956). On the growth and growth rate of aerosols from water soluble substances depending on the relative humidity. Zeitschr Aerosolforsch Therapie 5:263-88 (in German
62. Zhang Z, Kleinstreuer C, Kim CS. (2001). Flow structure and particle transport in a triple bifurcation model. J Fluids Eng 123:320-30
63. Zhang Z, Kleinstreuer C, Kim CS. (2006). Water vapour transport and its effect on the deposition of hygroscopic droplets in a human upper airway model. Aerosol Sci Technol 40:1-16