PG4KDS: A model for the clinical implementation of pre-emptive pharmacogenetics

American Journal of Medical Genetics, Part C: Seminars in Medical Genetics

Volumn 166, Issue 1, 2014, Pages 45-55

  Hoffman, James M ^a,b   Haidar, Cyrine E ^a,b   Wilkinson, Mark R ^a   Crews, Kristine R ^a   Baker, Donald K ^a   Kornegay, Nancy M ^a   Yang, Wenjian ^a   Pui, Ching Hon ^a,c   Reiss, Ulrike M ^a   Gaur, Aditya H ^a   Howard, Scott C ^a,d   Evans, William E ^a,d   Broeckel, Ulrich ^e   Relling, Mary V ^a,e  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF PHARMACY   (United States)

^c St Jude Cancer Center   (United States)

^d UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Clinical decision support; Electronic health record; Personalized medicine; Pharmacogenetics; Pharmacogenomics

Indexed keywords

AMITRIPTYLINE; AZATHIOPRINE; CLOPIDOGREL; CODEINE; DRUG METABOLIZING ENZYME; FLUOXETINE; MERCAPTOPURINE; ONDANSETRON; OXYCODONE; PAROXETINE; SIMVASTATIN; TIOGUANINE; TRAMADOL;

ARTICLE; CLINICAL LABORATORY; CYP2C19 GENE; CYP2D6 GENE; ELECTRONIC MEDICAL RECORD; FAMILY; GENE; GENE DOSAGE; GENETIC SCREENING; GENOTYPE; HUMAN; INCIDENTAL FINDING; INFORMATION SCIENCE; INFORMED CONSENT; MEDICAL INFORMATION SYSTEM; PATIENT; PATIENT EDUCATION; PERSONALIZED MEDICINE; PHARMACOGENETICS; PHARMACOGENOMICS; PHENOTYPE; PRACTICE GUIDELINE; PRESCRIPTION; PRIORITY JOURNAL; SLCO1B1 GENE; TPTM GENE;

CLINICAL DECISION SUPPORT; ELECTRONIC HEALTH RECORD; PERSONALIZED MEDICINE; PHARMACOGENETICS; PHARMACOGENOMICS;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2D6; ELECTRONIC HEALTH RECORDS; GENE DOSAGE; GENETIC TESTING; GENOTYPE; HUMANS; MEDICAL INFORMATICS APPLICATIONS; METHYLTRANSFERASES; MODELS, THEORETICAL; ORGANIC ANION TRANSPORTERS; PHARMACOGENETICS; PHYSICIAN'S PRACTICE PATTERNS; PROTEIN ARRAY ANALYSIS;

EID: 84896319867     PISSN: 15524868     EISSN: 15524876     Source Type: Journal    
DOI: 10.1002/ajmg.c.31391     Document Type: Article

References (30)

1. Altman R. 2013. Personal genomic measurements: The opportunity for information integration. Clin Pharmacol Ther 93:21-23.
2. Altman RB, Whirl-Carrillo M, Klein TE. 2013. Challenges in the pharmacogenomic annotation of whole genomes. Clin Pharmacol Ther 94:211-213.
3. Bell GC, Crews KR, Wilkinson MR, Haidar CE, Hicks JK, Baker DK, Kornegay NM, Yang W, Cross SJ, Howard SC, Freimuth RR, Evans WE, Broeckel U, Relling MV, Hoffman JM. 2014. Development and use of active clinical decision support for preemptive pharmacogenomics. J Am Med Inform Assoc 21:e93-9.
4. Cheok MH, Evans WE. 2006. Acute lymphoblastic leukaemia: A model for the pharmacogenomics of cancer therapy. Nat Rev Cancer 6:117-129.
5. Clayton EW. 2008. Incidental findings in genetics research using archived DNA. J Law Med Ethics 36:286-291.
6. Crews KR, Gaedigk A, Dunnenberger HM, Klein TE, Shen DD, Callaghan JT, Kharasch ED, Skaar TC. 2011a. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther 91:321-326.
7. Crews KR, Cross SC, McCormick JN, Baker DB, Molinelli AR, Mullins R, Relling MV, Hoffman JM. 2011b. Development and implementation of a pharmacist-managed clinical pharmacogenetics service. Am J Health Syst Pharm 68:143-150.
8. Evans WE, McLeod HL. 2003. Pharmacogenomics-drug disposition, drug targets, and side effects. N Engl J Med 348:538-549.
9. Evans WE, Relling MV. 1999. Pharmacogenomics: Translating functional genomics into rational therapeutics. Science 286:487-491.
10. Evans WE, Crews KR, Pui CH. 2013. A health-care system perspective on implementing genomic medicine: Pediatric acute lymphoblastic leukemia as a paradigm. Clin Pharmacol Ther 94:224-229.
11. Fernandez CA, Smith C, Yang W, Lorier R, Crews KR, Kornegay N, Hicks JK, Stewart CF, Kawedia DJ, Ramsey LB, Liu C, Evans WE, Relling MV, Broeckel U. 2012. Concordance of DMET Plus genotyping results with those of orthogonal genotyping methods. Clin Pharmacol Ther 92:360-365.
12. Green ED, Guyer MS. 2011. Charting a course for genomic medicine from base pairs to bedside. Nature 470:204-213.
13. Green RC, Berg JS, Grody WW, Kalia SS, Korf BR, Martin CL, McGuire A, Nussbaum RL, O'Daniel JM, Ormond KE, Rehm HL, Watson MS, Williams MS, Biesecker LG. 2013. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med 15:565-574.
14. Hicks JK, Crews KR, Hoffman JM, Kornegay NM, Wilkinson MR, Lorier R, Stoddard A, Yang W, Smith C, Fernandez CA, Cross SJ, Haidar C, Baker DK, Howard SC, Evans WE, Broeckel U, Relling MV. 2012. A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Clin Pharmacol Ther 92:563-566.
15. Johnson JA, Klein TE, Relling MV. 2013. Clinical implementation of pharmacogenetics: More than one gene at a time. Clin Pharmacol Ther 93:384-385.
16. Manolio TA, Green ED. 2011. Genomics reaches the clinic: From basic discoveries to clinical impact. Cell 147:14-16.
17. Meyer UA. 2004. Pharmacogenetics-decades of therapeutic lessons from genetic diversity. Nat Rev Genet 5:669-676.
18. Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH, Delaney JT, Bowton E, Brothers K, Johnson K, Crawford DC, Schildcrout J, Masys DR, Dilks HH, Wilke RA, Clayton EW, Shultz E, Laposata M, McPherson J, Hirjis JN, Roden DM. 2012. Operational implementation of prospective genotyping for personalized medicine: The design of the Vanderbilt PREDICT project. Clin Pharmacol Ther 92:87-95.
19. Relling MV, Klein TE. 2011. CPIC: Clinical Pharmacogenetics Implementation Consortium of the pharmacogenomics research network. Clin Pharmacol Ther 89:464-467.
20. Relling MV, Pui CH, Cheng C, Evans WE. 2006. Thiopurine methyltransferase in acute lymphoblastic leukemia. Blood 107:843-844.
21. Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Hicks JK, Schwab M, Klein TE. 2013. Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update. Clin Pharmacol Ther 93:324-325.
22. Scott SA, Sangkuhl K, Stein CM, Hulot JS, Mega JL, Roden DM, Klein TE, Sabatine MS, Johnson JA, Shuldiner AR. 2013. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy: 2013 Update. Clin Pharmacol Ther 94:317-323.
23. Shuldiner AR, Relling MV, Peterson JF, Hicks K, Freimuth RR, Sadee Pereira NL, Roden DM, Johnson JA, Klein TE. 2013. The Pharmacogenomics Research Network translational pharmacogenetics program: Overcoming challenges of real-world implementation. Clin Pharmacol Ther 94:207-210.
24. Sissung TM, English BC, Venzon D, Figg WD, Deeken JF. 2010. Clinical pharmacology and pharmacogenetics in a genomics era: The DMET platform. Pharmacogenomics 11:89-103.
25. Swen JJ, Nijenhuis M, de Boer A, Grandia L, Maitland-van der Zee AH, Mulder H, Rongen GA, van Schaik RH, Schalekamp T, Touw DJ, van der Weide J, Wilffert B, Deneer VH, Guchelaar HJ. 2011. Pharmacogenetics: From bench to byte-an update of guidelines. Clin Pharmacol Ther 89:662-673.
26. Veenstra DL, Roth JA, Garrison LP, Ramsey SD, Burke W. 2010. A formal risk-benefit framework for genomic tests: Facilitating the appropriate translation of genomics into clinical practice. Genet Med 12:686-693.
27. Voora D, Ginsburg GS. 2011. Institutional Profile: A hub for bench-to-bedside pharmacogenomic-based research. Pharmacogenomics 12:1095-1098.
28. Wang L, McLeod HL, Weinshilboum RM. 2011. Genomics and drug response. N Engl J Med 364:1144-1153.
29. Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M. 2012. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin Pharmacol Ther 92:112-117.
30. Wolf SM, Lawrenz FP, Nelson CA, Kahn JP, Cho MK, Clayton EW, Fletcher JG, Georgieff MK, Hammerschmidt D, Hudson K, Illes J, Kapur V, Keane MA, Koenig BA, Leroy BS, McFarland EG, Paradise J, Parker LS, Terry SF, Van Ness B, Wilfond BS. 2008. Managing incidental findings in human subjects research: Analysis and recommendations. J Law Med Ethics 36:219-248.