Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice

Journal of Controlled Release

Volumn 200, Issue , 2015, Pages 52-59

  Ishii Mizuno, Yumiko ^a   Umeki, Yuka ^a   Takahashi, Yuki ^a   Kato, Yukinori ^b   Takabayashi, Tetsuji ^b   Fujieda, Shigeharu ^b   Takakura, Yoshinobu ^a   Nishikawa, Makiya ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

Allergen; Controlled release; CpG motif; Hydrogel; Nasal delivery; Self gelling

Indexed keywords

ALLERGENS; ALLERGIES; DNA; GELATION; IMMUNE SYSTEM; IMMUNIZATION; MAMMALS;

CONTROLLED RELEASE; CONTROLLED RELEASE FORMULATIONS; CPG MOTIF; FLUORESCEIN ISOTHIOCYANATE; JAPANESE CEDAR POLLEN ALLERGEN; NASAL DELIVERY; PHOSPHATE BUFFED SALINES; SELF-GELLING;

HYDROGELS;

CRYJ1 POLLEN ANTIGEN; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOMODULATING AGENT; INTERLEUKIN 12; POLLEN ANTIGEN; SDNA HYDROGEL; UNCLASSIFIED DRUG; ALLERGEN; DNA; HYDROGEL; IMMUNOLOGICAL ADJUVANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL TRANSPORT; COMPARATIVE EFFECTIVENESS; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG UPTAKE; HYDROGEL; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSTIMULATION; IN VITRO STUDY; INCUBATION TEMPERATURE; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; NOSE CAVITY; NOSE MUCUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SPLEEN CELL; SUSTAINED DRUG RELEASE; TH2 CELL; ADMINISTRATION AND DOSAGE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL LINE; CPG ISLAND; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; JAPANESE CEDAR; POLLEN;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ALLERGENS; ANIMALS; CELL LINE; CPG ISLANDS; CRYPTOMERIA; DNA; HYDROGELS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-12; MALE; MICE, INBRED BALB C; NASAL LAVAGE FLUID; POLLEN;

EID: 84920749699     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.12.040     Document Type: Article

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