The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity

Biomaterials

Volumn 30, Issue 29, 2009, Pages 5701-5706

  Rattanakiat, Sakulrat ^a   Nishikawa, Makiya ^a   Funabashi, Hisakage ^b   Luo, Dan ^b   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Department of Biological and Environmental Engineering   (United States)

Author keywords

CpG motif; Dendrimer; Immunostimulatory activity; Oligodeoxynucleotides; Toll like receptor 9

Indexed keywords

CHEMICAL STRUCTURE; COMPLICATED STRUCTURES; CPG MOTIF; CYTOKINES; DENDRITIC STRUCTURES; DINUCLEOTIDES; IMMUNE SYSTEMS; IMMUNOSTIMULATORY ACTIVITY; INTERLEUKIN-6; MACROPHAGE-LIKE CELLS; OLIGODEOXYNUCLEOTIDES; PHOSPHODIESTERS; THERAPEUTIC AGENTS; THIRD GENERATION; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTORS;

CHEMICAL MODIFICATION; DENDRIMERS; DNA; GENES; MACROPHAGES; NUCLEIC ACIDS;

DNA SEQUENCES;

CYTOKINE; CYTOSINE; DENDRIMER; DOUBLE STRANDED DNA; ESTER DERIVATIVE; GUANINE; INTERLEUKIN 6; MONOMER; PHOSPHATE; SINGLE STRANDED DNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOKINE RELEASE; DNA SEQUENCE; DNA STRUCTURE; DRUG MECHANISM; DRUG STRUCTURE; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL LINE; CPG ISLANDS; CYTOKINES; DENDRIMERS; DNA; MACROPHAGES; RATS;

EID: 68549116992     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.06.053     Document Type: Article

References (46)

1. Krieg A. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20 (2002) 709-760
2. Vollmer J., and Krieg A.M. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev 61 (2009) 195-204
3. Mutwiri G.K., Nichani A.K., Babiuk S., and Babiuk L.A. Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides. J Control Release 97 (2004) 1-17
4. Agrawal S., and Zhao Q. Antisense therapeutics. Curr Opin Chem Biol 2 (1998) 519-528
5. Chavany C., Connell Y., and Neckers L. Contribution of sequence and phosphorothioate content to inhibition of cell growth and adhesion caused by c-myc antisense oligomers. Mol Pharmacol 48 (1995) 738-746
6. Crooke R.M. In vitro toxicology and pharmacokinetics of antisense oligonucleotides. Anticancer Drug Des 6 (1991) 609-646
7. Lappalainen K., Jääskeläinen I., Syrjänen K., Urtti A., and Syrjänen S. Comparison of cell proliferation and toxicity assays using two cationic liposomes. Pharm Res 11 (1994) 1127-1131
8. Plank C., Mechtler K., Szoka F.C., and Wagner E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther 7 (1996) 1437-1446
9. Bottega R., and Epand R.M. Inhibition of protein kinase C by cationic amphiphiles. Biochemistry 31 (1992) 9025-9030
10. Fischer D., Bieber T., Li Y., Elsässer H.-P., and Kissel T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 16 (1999) 1273-1279
11. Cong Y.P., Song S.S., Bhagat L., Pandey R.K., Yu D., Kandimalla E.R., et al. Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells. Biochem Biophys Res Commun 310 (2003) 1133-1139
12. Dalpke A., Zimmermann S., Albrecht I., and Heeg K. Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo. Immunology 106 (2002) 102-112
13. Kandimalla E.R., Bhagat L., Yu D., Cong Y., Tang J., and Agrawal S. Conjugation of ligands at the 5′-end of CpG DNA affects immunostimulatory activity. Bioconjug Chem 13 (2002) 966-974
14. Kandimalla E.R., Bhagat L., Cong Y.P., Pandey R.K., Yu D., Zhao Q., et al. Secondary structures in CpG oligonucleotides affect immunostimulatory activity. Biochem Biophys Res Commun 306 (2003) 948-953
15. Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
16. Shimosato T., Kimura T., Tohno M., Iliev I.D., Katoh S., Ito Y., et al. Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5′-C⋯G-3′ stem structure. Cell Microbiol 8 (2006) 485-495
17. Verthelyi D., Ishii K.J., Gursel M., Takeshita F., and Klinman D.M. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J Immunol 166 (2001) 2372-2377
18. Puig M., Grajkowski A., Boczkowska M., Ausin C., Beaucage S.L., and Verthelyi D. Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates. Nucleic Acids Res 34 (2006 December 2) 6488-6495
19. Andersen F., Knudsen B., Oliveira C.L., Frøhlich R.F., Krüger D., Bungert J., et al. Assembly and structural analysis of a covalently closed nano-scale DNA cage. Nucleic Acids Res 36 (2008) 1113-1119
20. He Y., Ye T., Su M., Zhang C., Ribbe A.E., Jiang W., et al. Hierarchical self-assembly of DNA into symmetric supramolecular polyhedral. Nature 452 (2008) 198-201
21. Li Y., Tseng Y.D., Kwon S.Y., D'espaux L., Bunch J.S., McEuen P.L., et al. Controlled assembly of dendrimer-like DNA. Nat Mater 3 (2004) 38-42
22. Nishikawa M., Matono M., Rattanakiat S., Matsuoka N., and Takakura Y. Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation. Immunology 124 (2008) 247-255
23. Agrawal S., and Kandimalla E.R. Role of Toll-like receptors in antisense and siRNA. Nat Biotechnol 22 (2004) 1533-1537
24. Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 4 (2004) 249-258
25. Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 5 (2006) 471-484
26. Agrawal S., and Kandimalla E.R. Medicinal chemistry and therapeutic potential of CpG DNA. Trends Mol Med 8 (2002) 114-121
27. Henry S., Giclas P.C., Leeds J., Pangburn M., Auletta C., Levin A.A., et al. Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action. J Pharmacol Exp Ther 281 (1997) 810-816
28. Yu D., Zhao Q., Kandimalla E.R., and Agrawal S. Accessible 5′-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity. Bioorg Med Chem Lett 10 (2000) 2585-2588
29. Yamamoto S., Yamamoto T., Iho S., and Tokunaga T. Activation of NK cell (human and mouse) by immunostimulatory DNA sequence. Springer Semin Immunopathol 22 (2000) 35-43
30. Wikstrom F.H., Meehan B.M., Berg M., Timmusk S., Elving J., Fuxler L., et al. Structure-dependent modulation of alpha interferon production by porcine circovirus 2 oligodeoxyribonucleotide and CpG DNAs in porcine peripheral blood mononuclear cells. J Virol 81 (2007) 4919-4927
31. Wu C.C., Lee J., Raz E., Corr M., and Carson D.A. Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem 279 (2004) 33071-33078
32. Rodriguez J.M., Elías F., Fló J., López R.A., Zorzopulos J., and Montaner A.D. Immunostimulatory PyNTTTTGT oligodeoxynucleotides: structural properties and refinement of the active motif. Oligonucleotides 16 (2006) 275-285
33. Vollmer J., Janosch A., Laucht M., Ballas Z.K., Schetter C., and Krieg A.M. Highly immunostimulatory CpG-free oligodeoxynucleotides for activation of human leukocytes. Antisense Nucleic Acid Drug Dev 12 (2002) 165-175
34. Vollmer J., Weeratna R.D., Jurk M., Samulowitz U., McCluskie M.J., Payette P., et al. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 113 (2004) 212-223
35. Wang J., Alvarez R., Roderiquez G., Guan E., Caldwell Q., Wang J., et al. CpG-independent synergistic induction of beta-chemokines and a dendritic cell phenotype by orthophosphorothioate oligodeoxynucleotides and granulocyte-macrophage colony-stimulating factor in elutriated human primary monocytes. J Immunol 174 (2005) 6113-6121
36. Haas T., Metzger J., Schmitz F., Heit A., Müller T., Latz E., et al. The DNA sugar backbone 2′ deoxyribose determines toll-like receptor 9 activation. Immunity 28 (2008) 315-323
37. Wagner H. The sweetness of the DNA backbone drives Toll-like receptor 9. Curr Opin Immunol 20 (2008) 396-400
38. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 5 (2004) 190-198
39. Roberts T.L., Dunn J.A., Terry T.D., Jennings M.P., Hume D.A., Sweet M.J., et al. Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides. J Immunol 175 (2005) 3569-3576
40. Aoyama Y., Kanamori T., Nakai T., Sasaki T., Horiuchi S., Sando S., et al. Artificial viruses and their application to gene delivery. Size-controlled gene coating with glycocluster nanoparticles. J Am Chem Soc 125 (2003) 3455-3457
41. Nakai T., Kanamori T., Sando S., and Aoyama Y. Remarkably size-regulated cell invasion by artificial viruses. Saccharide-dependent self-aggregation of glycoviruses and its consequences in glycoviral gene delivery. J Am Chem Soc 125 (2003) 8465-8475
42. Osaki F., Kanamori T., Sando S., Sera T., and Aoyama Y. A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. J Am Chem Soc 126 (2004) 6520-6521
43. Gao H., Shi W., and Freund L.B. Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci U S A 102 (2005) 9469-9474
44. Hirata K., Nishikawa M., Kobayashi N., Takahashi Y., and Takakura Y. Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression. J Pharm Sci 96 (2007) 2251-2261
45. Yu D., Putta M.R., Bhagat L., Li Y., Zhu F., Wang D., et al. Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs. J Med Chem 50 (2007) 6411-6418
46. Minari J., Shimada N., and Sakurai K. Clustered CpG sequences to enhance cytokine secretion from macrophages. Chem Lett 37 (2008) 92-93