High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice

Molecular Metabolism

Volumn 4, Issue 1, 2015, Pages 39-50

  Kahle, M ^a,c   Schafer A ^a,c   Seelig, A ^a   Schultheiss J ^a,c   Wu, M ^a,c   Aichler, M ^a   Leonhardt, J ^a   Rathkolb, B ^a,b   Rozman, J ^a,c   Sarioglu, H ^a   Hauck, S M ^a,c   Ueffing, M ^a,c   Wolf, E ^b   Kastenmueller, G ^a   Adamski, J ^a   Walch, A ^a   Hrabe de Angelis M ^a,c   Neschen, S ^a,c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

Author keywords

2 14C DG; ALT; AUC; B; Basal; Clamp; DAG; Diabetes; EGP; GIR; Hepatosteatosis; HF; IS; LF; LysoPC; Metabolomics; Mitochondria; NEFA; PCaa; PCae; Proteomics; Ra; Rd; Rg; ROS; SM; TAG; WAT

Indexed keywords

ACYLCARNITINE; DIACYLGLYCEROL; GLYCEROPHOSPHORYLCHOLINE DERIVATIVE; LONG CHAIN FATTY ACID; LYSOPHOSPHATIDYLCHOLINE; MEMBRANE LIPID; MEMBRANE PROTEIN; SPHINGOLIPID; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; FATTY LIVER; HEPATIC INSULIN RESISTANCE; INNER MEMBRANE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID COMPOSITION; LIPID DIET; LIVER CELL; LIVER DISEASE; MALE; METABOLOMICS; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL VOLUME; MOUSE; NONHUMAN; OUTER MEMBRANE; OXIDATIVE STRESS; PROTEIN MODIFICATION; PROTEOMICS; QUANTITATIVE ANALYSIS; RESPIRATORY CHAIN;

MUS;

EID: 84920747259     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.11.004     Document Type: Article

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