Targeted metabolomics of dried blood spot extracts

Chromatographia

Volumn 76, Issue 19-20, 2013, Pages 1295-1305

  Zukunft, Sven ^a,c   Sorgenfrei, Martina ^a   Prehn, Cornelia ^a   Möller, Gabriele ^a   Adamski, Jerzy ^a,b,c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

Author keywords

Dried blood spots; Lipids; Mass spectrometry; Metabolite quantification; Targeted metabolomics

Indexed keywords

ACYLCARNITINE; BIOGENIC AMINE; CARNITINE; DRUG METABOLITE; GLYCEROPHOSPHOLIPID; HEXOSE; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; SPHINGOLIPID;

ARTICLE; BLOOD SAMPLING; DRIED BLOOD SPOT TESTING; FEMALE; HEMATOCRIT; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; METABOLIC DISORDER; METABOLOMICS; PRIORITY JOURNAL; VENOUS BLOOD;

EID: 84885183153     PISSN: 00095893     EISSN: 16121112     Source Type: Journal    
DOI: 10.1007/s10337-013-2429-3     Document Type: Article

References (30)

1. Ceglarek U, Müller P, Stach B, Bührdel P, Thiery J, Kiess W (2002) Validation of the phenylalanine/tyrosine ratio determined by tandem mass spectrometry: sensitive newborn screening for phenylketonuria. Clin Chem Lab Med 40(7):693-697
2. Rashed MS (2001) Clinical applications of tandem mass spectrometry: ten years of diagnosis and screening for inherited metabolic diseases. J Chromatogr B Biomed Sci Appl 758(1):27-48
3. Déglon J, Thomas A, Mangin P, Staub C (2012) Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications. Anal Bioanal Chem 402(8):2485-2498
4. Leichtle AB, Ceglarek U, Witzigmann H, Thiery J, Fiedler GM (2010) Potential of dried blood self-sampling for cyclosporine C 2 monitoring in transplant outpatients. J Transplant. doi: 10.1155/2010/201918
5. Barfield M, Spooner N, Lad R, Parry S, Fowles S (2008) Application of dried blood spots combined with HPLC-MS/MS for the quantification of acetaminophen in toxicokinetic studies. J Chromatogr B 870(1):32-37
6. Spooner N, Lad R, Barfield M (2009) Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method. Anal Chem 81(4):1557-1563
7. Möller I, Thomas A, Geyer H, Schänzer W, Thevis M (2012) Development and validation of a mass spectrometric detection method of peginesatide in dried blood spots for sports drug testing. Anal Bioanal Chem 403(9):2715-2724
8. Michopoulos F, Lai L, Gika H, Theodoridis G, Wilson I (2009) UPLC-MS-based analysis of human plasma for metabonomics using solvent precipitation or solid phase extraction. J Proteome Res 8(4):2114-2121
9. McDade TW, Williams S, Snodgrass JJ (2007) What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research. Demography 44(4):899-925
10. Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS, Mewes HW (2009) A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42(2):137-141
11. Gonçalves I, Edsfeldt A, Ko NY, Grufman H, Berg K, Björkbacka H, Nitulescu M, Persson A, Nilsson M, Prehn C (2012) Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation. Arterioscler Thromb Vasc Biol 32(6):1505-1512
12. Renner S, Römisch-Margl W, Prehn C, Krebs S, Adamski J, Göke B, Blum H, Suhre K, Roscher AA, Wolf E (2012) Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass. Diabetes 61(8):2166-2175
13. Vouk K, Hevir N, Ribič-Pucelj M, Haarpaintner G, Scherb H, Osredkar J, Möller G, Prehn C, Rižner TL, Adamski J (2012) Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis. Hum Reprod 27(10):2955-2965
14. Römisch-Margl W, Prehn C, Bogumil R, Röhring C, Suhre K, Adamski J (2012) Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics. Metabolomics 8(1):133-142
15. Jourdan C, Petersen AK, Gieger C, Döring A, Illig T, Wang-Sattler R, Meisinger C, Peters A, Adamski J, Prehn C (2012) Body fat free mass is associated with the serum metabolite profile in a population-based study. PLoS One 7(6):e40009
16. RDevelopment C (2012) TEAM (2008): R: A language and environment for statistical computing. Vienna, Austria. Internet: http://www.R-project.org. Accessed 10.10. 2012
17. Kastenmüller G, Römisch-Margl W, Wägele B, Altmaier E, Suhre K (2011) metaP-server: a web-based metabolomics data analysis tool. J Biomed Biotechnol 2011. doi: 10.1155/2011/839862
18. Guidance for Industry. Bioanalytical method validation. US Department of Health and Human Services, Food and Drug Administration, 2001
19. Shah VP, Midha KK, Findlay JWA, Hill HM, Hulse JD, McGilveray IJ, McKay G, Miller KJ, Patnaik RN, Powell ML (2000) Bioanalytical method validation - a revisit with a decade of progress. Pharm Res 17(12):1551-1557
20. Brauer R, Leichtle AB, Fiedler GM, Thiery J, Ceglarek U (2011) Preanalytical standardization of amino acid and acylcarnitine metabolite profiling in human blood using tandem mass spectrometry. Metabolomics 7(3):344-352
21. Mei JV, Alexander JR, Adam BW, Hannon WH (2001) Use of filter paper for the collection and analysis of human whole blood specimens. J Nutr 131(5):1631S-1636S
22. Holub M, Tuschl K, Ratschmann R, Strnadová KA, Mühl A, Heinze G, Sperl W, Bodamer OA (2006) Influence of hematocrit and localisation of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry. Clin Chim Acta 373(1):27-31
23. Van Eeckhaut A, Lanckmans K, Sarre S, Smolders I, Michotte Y (2009) Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. J Chromatogr B 877(23):2198-2207
24. Chambers E, Wagrowski-Diehl DM, Lu Z, Mazzeo JR (2007) Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J Chromatogr B 852(1-2):22-34
25. Rogatsky E, Stein D (2005) Evaluation of matrix effect and chromatography efficiency: new parameters for validation of method development. J Am Soc Mass Spectrom 16(11):1757-1759
26. Identifying inherited metabolic disorders using the API 3200 LC/MS/MS system (2006). Application note, Applied biosystems 114AP54-01
27. Bell JG, Mackinlay EE, Dick JR, Younger I, Lands B, Gilhooly T (2011) Using a fingertip whole blood sample for rapid fatty acid measurement: method validation and correlation with erythrocyte polar lipid compositions in UK subjects. Br J Nutr 106(9):1408
28. Chace DH, Adam BW, Smith SJ, Alexander JR, Hillman SL, Hannon WH (1999) Validation of accuracy-based amino acid reference materials in dried-blood spots by tandem mass spectrometry for newborn screening assays. Clin Chem 45(8):1269-1277
29. Strnadová KA, Holub M, Mühl A, Heinze G, Ratschmann R, Mascher H, Stöckler-Ipsiroglu S, Waldhauser F, Votava F, Lebl J (2007) Long-term stability of amino acids and acylcarnitines in dried blood spots. Clin Chem 53(4):717-722
30. Madira W, Xavier F, Stern J, Wilcox A, Barron J (1992) Determination and assessment of the stability of phenylalanine and tyrosine in blood spots by HPLC. Clin Chem 38(10):2162-2163