Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection

Journal of Cellular Physiology

Volumn 222, Issue 1, 2010, Pages 73-81

  Connelly, Linda ^a   Barham, Whitney ^a   Pigg, Rachel ^a   Saint Jean, Leshana ^a   Sherrill, Taylor ^b   Cheng, Dong Sheng ^b   Chodosh, Lewis A ^c   Blackwell, Timothy S ^a,b,d   Yull, Fiona E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DOXYCYCLINE; I KAPPA B KINASE; I KAPPA B KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST DEVELOPMENT; BREAST EPITHELIUM; BREAST MILK; CELL ACTIVATION; CONTROLLED STUDY; DNA FLANKING REGION; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; GROWTH INHIBITION; INJECTION; INVOLUTION; LACTATION; MAMMARY GLAND; MASTITIS; MILK PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENE;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; DOXYCYCLINE; EPITHELIAL CELLS; EPITHELIUM; FEMALE; LACTATION; LIPOPOLYSACCHARIDES; MAMMARY GLANDS, ANIMAL; MASTITIS; MICE; MICE, TRANSGENIC; MILK; MILK PROTEINS; NF-KAPPA B; SIGNAL TRANSDUCTION; UP-REGULATION;

MURINAE; MUS MUSCULUS;

EID: 73949129285     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21922     Document Type: Article

References (35)

1. Baeuerle PA, Baltimore D. 1988. I kappa B: A specific inhibitor of the NF-kappa B transcription factor. Science 242:540-546.
2. Baldwin AS, Jr. 1996. The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu Rev Immunol 14:649-683.
3. Baxter FO, Came PJ, Abell K, Kedjouar B, Huth M, Rajewsky K, Pasparakis M, Watson CJ. 2006. IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells. Development 133:3485-3494.
4. Baxter FO, Neoh K, Tevendale MC. 2007. The beginning of the end: Death signaling in early involution. J Mammary Gland Biol Neoplasia 12:3-13.
5. Boulanger D, Bureau F, Melotte D, Mainil J, Lekeux P. 2003. Increased nuclear factor kappaB activity in milk cells of mastitis-affected cows. J Dairy Sci 86:1259-1267.
6. Boutet P, Sulon J, Closset R, Detilleux J, Beckers JF, Bureau F, Lekeux P. 2007. Prolactin-induced activation of nuclear factor kappaB in bovine mammary epithelial cells: Role in chronic mastitis. J Dairy Sci 90:155-164.
7. Brantley DM, Yull FE, Muraoka RS, Hicks DJ, Cook CM, Kerr LD. 2000. Dynamic expression and activity of NF-kappaB during post-natal mammary gland morphogenesis. Mech Dev 97:149-155.
8. Brantley DM, Chen CL, Muraoka RS, Bushdid PB, Bradberry JL, Kittrell F, Medina D, Matrisian LM, Kerr LD, Yull FE. 2001. Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell 12:1445-1455.
9. Breitschopf K, Zeiher AM, Dimmeler S. 2000. Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction. J Biol Chem 275:21648-21652.
10. Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. 2001. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107:763-775.
11. Cheng DS, Han W, Chen SM, Sherrill TP, Chont M, Park GY, Sheller JR, Polosukhin VV, Christman JW, Yull FE, Blackwell TS. 2007. Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. J Immunol 178:6504-6513.
12. Clarkson RW, Watson CJ. 1999. NF-kappaB and apoptosis in mammary epithelial cells. J Mammary Gland Biol Neoplasia 4:165-175.
13. Clarkson RW, Heeley JL, Chapman R, Aillet F, Hay RT, Wyllie A, Watson CJ. 2000. NF-kappaB inhibits apoptosis in murine mammary epithelia. J Biol Chem 275:12737-12742.
14. Clarkson RW, Wayland MT, Lee J, Freeman T, Watson CJ. 2004. Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res 6:R92-R109.
15. Connelly L, Jacobs AT, Palacios-Callender M, Moncada S, Hobbs AJ. 2003. Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem 278:26480-26487.
16. Connelly L, Robinson-Benion C, Chont M, Saint-Jean L, Li H, Polosukhin VV, Blackwell TS, Yull FE. 2007. A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. J Biol Chem 282:10028-10035.
17. Danial NN. 2007. BCL-2 family proteins: Critical checkpoints of apoptotic cell death. Clin Cancer Res 13:7254-7263.
18. Demicco EG, Kavanagh KT, Romieu-Mourez R, Wang X, Shin SR, Landesman-Bollag E, Seldin DC, Sonenshein GE. 2005. RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland. Mol Cell Biol 25:10136-10147.
19. Everhart MB, Han W, Sherrill TP, Arutiunov M, Polosukhin VV, Burke JR, Sadikot RT, Christman JW, Yull FE, Blackwell TS. 2006. Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol 176:4995-5005.
20. Furth PA. 1999. Introduction: Mammary gland involution and apoptosis of mammary epithelial cells. J Mammary Gland Biol Neoplasia 4:123-127.
21. Geymayer S, Doppler W. 2000. Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression. FASEB J 14:1159-1170.
22. Ghosh S, May MJ, Kopp EB. 1998. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260.
23. Gunther EJ, Belka GK, Wertheim GB, Wang J, Hartman JL, Boxer RB, Chodosh LA. 2002. Anovel doxycycline-inducible system for the transgenic analysis of mammary gland biology. FASEB J 16:283-292.
24. Hennighausen L, Robinson GW. 2005. Information networks in themammary gland. Nat Rev Mol Cell Biol 6:715-725.
25. Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol 18:621-663.
26. Kucharczak J, Simmons MJ, Fan Y, Gelinas C. 2003. To be, or not to be: NF-kappaB is the answer-Role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22:8961-8982.
27. Medina D. 1996. The mammary gland: A unique organ for the study of development and tumorigenesis. J Mammary Gland Biol Neoplasia 1:5-19.
28. Notebaert S, Carlsen H, Janssen D, Vandenabeele P, Blomhoff R, Meyer E. 2008a. In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection. Cell Microbiol 10:1249-1258.
29. Notebaert S, Demon D, Vanden Berghe T, Vandenabeele P, Meyer E. 2008b. Inflammatory mediators in Escherichia coli-induced mastitis in mice. Comp Immunol Microbiol Infect Dis 31:551-565.
30. Radhakrishnan SK, Kamalakaran S. 2006. Pro-apoptotic role of NF-kappaB: Implications for cancer therapy. Biochim Biophys Acta 1766:53-62.
31. Safieh-Garabedian B, Mouneimne GM, El-Jouni W, Khattar M, Talhouk R. 2004. The effect of endotoxin on functional parameters of mammary CID-9 cells. Reproduction 127:397-406.
32. Sarig R, Zaltsman Y, Marcellus RC, Flavell R, Mak TW, Gross A. 2003. BID-D59A is a potent inducer of apoptosis in primary embryonic fibroblasts. J Biol Chem 278:10707-10715.
33. Valentijn AJ, Gilmore AP. 2004. Translocation of full-length Bid to mitochondria during anoikis. J Biol Chem 279:32848-32857.
34. Yin XM. 2006. Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene 369:7-19.
35. Zhao X, Lacasse P. 2008. Mammary tissue damage during bovine mastitis: Causes and control. J Anim Sci 86:57-65.