MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 168-182

  Wang, Wenzhang ^a   Zhang, Fan ^a,b   Li, Li ^a   Tang, Fangqiang ^a   Siedlak, Sandra L ^a   Fujioka, Hisashi ^a   Liu, Yingchao ^b   Su, Bo ^b   Pi, Yan ^c   Wang, Xinglong ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b SHANDONG UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BRAIN; CELL MEMBRANES; CHEMICAL ACTIVATION; DYNAMICS; MITOCHONDRIA;

CALPAIN ACTIVATION; CYSTEINE PROTEASE; GLUTAMATE EXCITOTOXICITY; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL MORPHOLOGY; MOLECULAR MECHANISM;

NEURONS;

CALPAIN; GLUTAMIC ACID; MITOFUSIN 2; CALCIUM; GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; MFN2 PROTEIN, MOUSE; MITOCHONDRIAL PROTEIN; MITOFUSIN 2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENZYME ACTIVATION; ENZYME DEGRADATION; EXCITOTOXICITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL FRAGMENTATION; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SPINAL CORD MOTONEURON; ANIMAL; CELL DEATH; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MAMMALIAN EMBRYO; METABOLISM; MITOCHONDRION; MOTONEURON; PATHOLOGY; PRIMARY CELL CULTURE; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE; ULTRASTRUCTURE;

MUS;

ANIMALS; CALCIUM; CALPAIN; CELL DEATH; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION; GLUTAMIC ACID; GTP PHOSPHOHYDROLASES; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; MOTOR NEURONS; PRIMARY CELL CULTURE; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 84920694484     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.617167     Document Type: Article

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