Nitrite and nitrate concentrations and metabolism in breast milk, infant formula, and parenteral nutrition

Journal of Parenteral and Enteral Nutrition

Volumn 38, Issue 7, 2014, Pages 856-866

  Jones, Jesica A ^a   Ninnis, Janet R ^a   Hopper, Andrew O ^a   Ibrahim, Yomna ^a   Merritt, T Allen ^a,c   Wan, Kim Wah ^a   Power, Gordon G ^b   Blood, Arlin B ^a,b  

^a LOMA LINDA UNIVERSITY   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

dietary nitrate; dietary nitrite; human milk; lactoperoxidase; newborn infants; nitric oxide; nitrite oxidation; parenteral nutrition

Indexed keywords

DISSOLVED OXYGEN; FERRICYANIDE; LACTOPEROXIDASE; LIPID; MILK PROTEIN; NITRATE; NITRITE; OXYGEN; XANTHINE OXIDASE; NITRIC ACID DERIVATIVE; PARENTERAL SOLUTION;

ADULT; ARTICLE; ARTIFICIAL MILK; BACTERIAL FLORA; BLOOD LEVEL; BRAIN BLOOD FLOW; BREAST MILK; CLINICAL ARTICLE; COLOSTRUM; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOOD COMPOSITION; FREEZE THAWING; HUMAN; INFANT; INFANT NUTRITION; METABOLISM; MILK LEVEL; NEWBORN; OXIDATION; OXYGEN TENSION; PARENTERAL NUTRITION; PREMATURITY; PRIORITY JOURNAL; TEMPERATURE; ANIMAL; CHEMISTRY; DIET; FREEZING;

BACTERIA (MICROORGANISMS);

ADULT; ANIMALS; DIET; FEMALE; FREEZING; HUMANS; INFANT; INFANT FORMULA; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; INFANT, PREMATURE; MILK, HUMAN; NITRATES; NITRITES; PARENTERAL NUTRITION SOLUTIONS;

EID: 84920617932     PISSN: 01486071     EISSN: 19412444     Source Type: Journal    
DOI: 10.1177/0148607113496118     Document Type: Article

References (50)

1. Tota B, Quintieri AM, Angelone T. The emerging role of nitrite as an endogenous modulator and therapeutic agent of cardiovascular function. Curr Med Chem. 2010 ; 17 (18). 1915-1925
2. Jung KH, Chu K, Ko SY, et al. Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury. Stroke. 2006 ; 37 (11). 2744-2750
3. Jung KH, Chu K, Ko SY, et al. Effects of long term nitrite therapy on functional recovery in experimental ischemia model. Biochem and Biophys Res Comm. 2010 ; 403: 66-72
4. Duranski MR, Greer JJ, Dejam A, et al. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest. 2005 ; 115 (5). 1232-1240
5. Webb A, Bond R, McLean P, Uppal R, Benjamin N, Ahluwalia A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci U S A. 2004 ; 101 (37). 13683-13688
6. Pickerodt PA, Emery MJ, Zarndt R, et al. Sodium nitrite mitigates ventilator-induced lung injury in rats. Anesthesiology. 2012 ; 117 (3). 592-601
7. Tripatara P, Patel NS, Webb A, et al. Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase. J Am Soc Nephrol. 2007 ; 18 (2). 570-580
8. Kleinbongard P, Dejam A, Lauer T, et al. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med. 2003 ; 35 (7). 790-796
9. Duncan C, Dougall H, Johnston P, et al. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med. 1995 ; 1 (6). 546-551
10. Webb AJ, Patel N, Loukogeorgakis S, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008 ; 51 (3). 784-790
11. Rocha BS, Gago B, Barbosa RM, Lundberg JO, Radi R, Laranjinha J. Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling. Free Radic Biol Med. 2012 ; 52 (3). 693-698
12. Jin L, Qin L, Xia D, et al. Active secretion and protective effect of salivary nitrate against stress in human volunteers and rats. Free Radic Biol Med. 2013 ; 57: 61-67
13. Petersson J, Phillipson M, Jansson EA, Patzak A, Lundberg JO, Holm L. Dietary nitrate increases gastric mucosal blood flow and mucosal defense. Am J Physiol Gastrointest Liver Physiol. 2007 ; 292 (3). G718-724
14. Jansson EA, Petersson J, Reinders C, et al. Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate. Free Radic Biol Med. 2007 ; 42 (4). 510-518
15. Kanady JA, Aruni AW, Ninnis JR, et al. Nitrate reductase activity of bacteria in saliva of term and preterm infants. Nitric Oxide. 2012 ; 27 (4). 193-200
16. Ibrahim YI, Ninnis JR, Hopper AO, et al. Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension. J Pediatr. 2012 ; 160 (2). 245-251
17. Ohta N, Tsukahara H, Ohshima Y, et al. Nitric oxide metabolites and adrenomedullin in human breast milk. Early Hum Dev. 2004 ; 78 (1). 61-65
18. Hord NG, Ghannam JS, Garg HK, Berens PD, Bryan NS. Nitrate and nitrite content of human, formula, bovine, and soy milks: implications for dietary nitrite and nitrate recommendations. Breastfeed Med. 2011 ; 6 (6). 393-399
19. Cham BE, Knowles BR. A solvent system for delipidation of plasma or serum without protein precipitation. J Lipid Res. 1976 ; 17 (2). 176-181
20. Conahey GR, Power GG, Hopper AO, Terry MH, Kirby LS, Blood AB. Effect of inhaled nitric oxide on cerebrospinal fluid and blood nitrite concentrations in newborn lambs. Pediatr Res. 2008 ; 64 (4). 375-380
21. Sadowitz PD, Hubbard BA, Dabrowiak JC, et al. Kinetics of cisplatin binding to cellular DNA and modulations by thiol-blocking agents and thiol drugs. Drug Metab Dispos. 2002 ; 30 (2). 183-190
22. Doerge DR, Niemczura WP. Suicide inactivation of lactoperoxidase by 3-amino-1,2,4-triazole. Chem Res Toxicol. 1989 ; 2 (2). 100-103
23. Bandyopadhyay U, Bhattacharyya DK, Chatterjee R, Banerjee RK. Irreversible inactivation of lactoperoxidase by mercaptomethylimidazole through generation of a thiyl radical: its use as a probe to study the active site. Biochem J. 1995 ; 306 (Pt 3). 751-757
24. Michot JL, Nunez J, Johnson ML, Irace G, Edelhoch H. Iodide binding and regulation of lactoperoxidase activity toward thyroid goitrogens. J Biol Chem. 1979 ; 254 (7). 2205-2209
25. Shin K, Tomita M, Lonnerdal B. Identification of lactoperoxidase in mature human milk. J Nutr Biochem. 2000 ; 11 (2). 94-102
26. Pelletier MM, Kleinbongard P, Ringwood L, et al. The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. Free Radic Biol Med. 2006 ; 41 (4). 541-548
27. Stevens CR, Millar TM, Clinch JG, Kanczler JM, Bodamyali T, Blake DR. Antibacterial properties of xanthine oxidase in human milk. Lancet. 2000 ; 356 (9232). 829-830
28. Gothefors L, Marklund S. Lactoperoxidase activity in human milk and in saliva of newborn infants. Infect Immun. 1975 ; 11 (6). 1210-1215
29. Ostdal H, Bjerrum MJ, Pedersen JA, Andersen HJ. Lactoperoxidase-induced protein oxidation in milk. J Agric Food Chem. 2000 ; 48 (9). 3939-3944
30. van der Vliet A, Eiserich JP, Halliwell B, Cross CE. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicity. J Biol Chem. 1997 ; 272 (12). 7617-7625
31. Ustundag B, Yilmaz E, Dogan Y, et al. Levels of cytokines (IL-1beta, IL-2, IL-6, IL-8, TNF-alpha) and trace elements (Zn, Cu) in breast milk from mothers of preterm and term infants. Mediators Inflamm. 2005 ; 2005 (6). 331-336
32. Molinari CE, Casadio YS, Hartmann BT, Arthur PG, Hartmann PE. Longitudinal analysis of protein glycosylation and beta-casein phosphorylation in term and preterm human milk during the first 2 months of lactation. Br J Nutr. 2012 ;: 1-11
33. Wight NE. Donor human milk for preterm infants. J Perinatol. 2001 ; 21 (4). 249-254
34. Kulski JK, Hartmann PE. Changes in human milk composition during the initiation of lactation. Aust J Exp Biol Med Sci. 1981 ; 59 (1). 101-114
35. Hancock JT, Salisbury V, Ovejero-Boglione MC, et al. Antimicrobial properties of milk: dependence on presence of xanthine oxidase and nitrite. Antimicrob Agents Chemother. 2002 ; 46 (10). 3308-3310
36. Li H, Cui H, Kundu TK, Alzawahra W, Zweier JL. Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase. J Biol Chem. 2008 ; 283 (26). 17855-17863
37. Silanikove N, Shapiro F, Shamay A, Leitner G. Role of xanthine oxidase, lactoperoxidase, and NO in the innate immune system of mammary secretion during active involution in dairy cows: Manipulation with casein hydrolyzates. Free Radic Biol Med. 2005 ; 38: 1139-1151
38. Pennington JAT. Dietary exposure models for nitrates and nitrites. Food Control. 1998 ; 9 (6). 385-395
39. Bryan NS, Calvert JW, Gundewar S, Lefer DJ. Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice. Free Radic Biol Med. 2008 ; 45 (4). 468-474
40. Raat NJ, Noguchi AC, Liu VB, et al. Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response. Free Radic Biol Med. 2009 ; 47 (5). 510-517
41. Milkowski A, Garg HK, Coughlin JR, Bryan NS. Nutritional epidemiology in the context of nitric oxide biology: a risk-benefit evaluation for dietary nitrite and nitrate. Nitric Oxide. 2010 ; 22 (2). 110-119
42. Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009 ; 90 (1). 1-10
43. Power GG, Bragg SL, Oshiro BT, Dejam A, Hunter CJ, Blood AB. A novel method of measuring reduction of nitrite-induced methemoglobin applied to fetal and adult blood of humans and sheep. J Appl Physiol. 2007 ; 103 (4). 1359-1365
44. Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011 ; 364 (3). 255-264
45. Bjorne HH, Petersson J, Phillipson M, Weitzberg E, Holm L, Lundberg JO. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest. 2004 ; 113 (1). 106-114
46. Dykhuizen RS, Frazer R, Duncan C, et al. Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense. Antimicrob Agents Chemother. 1996 ; 40 (6). 1422-1425
47. Yazji I, Sodhi CP, Lee EK, et al. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A. 2013 ; 110: 9451-9456
48. Weitzberg E, Lundberg JO. Novel aspects of dietary nitrate and human health. Annu Rev Nutr. :
49. Dezfulian C, Raat N, Shiva S, Gladwin MT. Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. Cardiovasc Res. 2007 ; 75 (2). 327-338
50. Blood AB, Tiso M, Verma ST, et al. Increased nitrite reductase activity of fetal versus adult ovine hemoglobin. Am J Physiol Heart Circ Physiol. 2009 ; 296 (2). H237-246