Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation

Journal of Biological Chemistry

Volumn 290, Issue 1, 2015, Pages 467-477

  Cho, Young Lai ^a   Hur, Sung Mo ^a   Kim, Ji Yoon ^a   Kim, Ji Hee ^a   Lee, Dong Keon ^a   Choe, Jongeon ^a   Won, Moo Ho ^a   Ha, Kwon Soo ^a   Jeoung, Dooil ^a   Han, Sanghwa ^a   Ryoo, Sungwoo ^a   Lee, Hansoo ^a   Min, Jeong Ki ^b,d   Kwon, Young Guen ^b   Kim, Dong Hyun ^c   Kim, Young Myeong ^a  

^a Kangwon National University   (South Korea)

^b Yonsei University   (South Korea)

^c Kyung Hee University   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; ENDOTHELIAL CELLS; INSULIN; MAMMALS; NITRIC OXIDE;

ENDOTHELIAL FUNCTION; ENDOTHELIAL NITRIC-OXIDE SYNTHASE (ENOS); HUMAN ENDOTHELIAL CELLS; INSULIN-LIKE GROWTH FACTOR-1 RECEPTORS; NEO-VASCULARIZATION; PHOSPHOLIPASE C; STEAMING PROCESS; VASODILATIVE ACTIVITIES;

BIOACTIVITY;

FOCAL ADHESION KINASE; GINSENOSIDE RG5; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE C; PROTEIN KINASE B; SAPONIN; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; ANGIOGENIC FACTOR; APOLIPOPROTEIN E; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FOCAL ADHESION KINASE 1; GINSENOSIDE; INSULIN-LIKE GROWTH FACTOR-1, MOUSE; NOS3 PROTEIN, MOUSE; PTK2 PROTEIN, MOUSE; SMALL INTERFERING RNA; SOMATOMEDIN C;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD VESSEL PERMEABILITY; CALCIUM MOBILIZATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIMB ISCHEMIA; MALE; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VASCULITIS; VASODILATATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HINDLIMB; ISCHEMIA; METABOLISM; PATHOLOGY; TISSUE CULTURE TECHNIQUE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

MUS; PANAX GINSENG;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; AORTA; APOLIPOPROTEINS E; ENDOTHELIUM, VASCULAR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION; GINSENOSIDES; HINDLIMB; HUMANS; INSULIN-LIKE GROWTH FACTOR I; ISCHEMIA; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; TYPE C PHOSPHOLIPASES; VASODILATION;

EID: 84920540542     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.603142     Document Type: Article

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