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Volumn 401, Issue 1, 2007, Pages 269-277

Precise mapping of an IGF-I-binding site on the IGF-1R

Author keywords

Binding epitope; Cancer; Insulin like growth factor (IGF); Monoclonal antibody; Type 1 insulin like growth factor receptor (IGF 1R)

Indexed keywords

BINDING EPITOPE; INSULIN-LIKE GROWTH FACTOR (IGF); MONOCLONAL ANTIBODY; TYPE 1 INSULIN-LIKE GROWTH FACTOR RECEPTOR (IGF-1R);

EID: 33846332792     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060890     Document Type: Article
Times cited : (45)

References (45)
  • 2
    • 0033906634 scopus 로고    scopus 로고
    • Structure and function of the type 1 insulin-like growth factor receptor
    • Adams, T. E., Epa, V. C., Garrett, T. P. and Ward, C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell. Mol. Life Sci. 57, 1050-1093
    • (2000) Cell. Mol. Life Sci , vol.57 , pp. 1050-1093
    • Adams, T.E.1    Epa, V.C.2    Garrett, T.P.3    Ward, C.W.4
  • 3
    • 0036782071 scopus 로고    scopus 로고
    • Structural biology of insulin and IGF1 receptors: Implications for drug design
    • De Meyts, P. and Whittaker, J. (2002) Structural biology of insulin and IGF1 receptors: implications for drug design. Nat. Rev. Drug Discov. 1, 769-783
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 769-783
    • De Meyts, P.1    Whittaker, J.2
  • 4
    • 0027955344 scopus 로고
    • Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action
    • Kato, H., Faria, T. N., Stannard, B., Roberts, Jr, C. T. and Le Roith, D. (1994) Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action. Mol. Endocrinol. 8, 40-50
    • (1994) Mol. Endocrinol , vol.8 , pp. 40-50
    • Kato, H.1    Faria, T.N.2    Stannard, B.3    Roberts Jr, C.T.4    Le Roith, D.5
  • 5
    • 0346725862 scopus 로고    scopus 로고
    • Regulation of IGF-I receptor signaling in tumor cells
    • O'Connor, R. (2003) Regulation of IGF-I receptor signaling in tumor cells. Horm. Metab. Res. 35, 771-777
    • (2003) Horm. Metab. Res , vol.35 , pp. 771-777
    • O'Connor, R.1
  • 6
    • 3142690018 scopus 로고    scopus 로고
    • Signalling by the type 1 insulin-like growth factor receptor: Interplay with the epidermal growth factor receptor
    • Adams, T. E., McKern, N. M. and Ward, C. W. (2004) Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor. Growth Factors 22, 89-95
    • (2004) Growth Factors , vol.22 , pp. 89-95
    • Adams, T.E.1    McKern, N.M.2    Ward, C.W.3
  • 7
    • 33344467985 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor pathways
    • Yee, D. (2006) Targeting insulin-like growth factor pathways. Br. J. Cancer 94, 465-468
    • (2006) Br. J. Cancer , vol.94 , pp. 465-468
    • Yee, D.1
  • 8
    • 28544444712 scopus 로고    scopus 로고
    • Type I insulin-like growth factor receptor as a therapeutic target in cancer
    • Miller, B. S. and Yee, D. (2005) Type I insulin-like growth factor receptor as a therapeutic target in cancer. Cancer Res. 65, 10123-10127
    • (2005) Cancer Res , vol.65 , pp. 10123-10127
    • Miller, B.S.1    Yee, D.2
  • 10
    • 0035941231 scopus 로고    scopus 로고
    • Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site
    • Whittaker, J., Groth, A. V., Mynarcik, D. C., Pluzek, L., Gadsboll, V. L. and Whittaker, L. J. (2001) Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site. J. Biol. Chem. 276, 43980-43986
    • (2001) J. Biol. Chem , vol.276 , pp. 43980-43986
    • Whittaker, J.1    Groth, A.V.2    Mynarcik, D.C.3    Pluzek, L.4    Gadsboll, V.L.5    Whittaker, L.J.6
  • 11
    • 2342551975 scopus 로고    scopus 로고
    • Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis
    • Sorensen, H., Whittaker, L., Hinrichsen, J., Groth, A. and Whittaker, J. (2004) Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis. FEBS Lett. 565, 19-22
    • (2004) FEBS Lett , vol.565 , pp. 19-22
    • Sorensen, H.1    Whittaker, L.2    Hinrichsen, J.3    Groth, A.4    Whittaker, J.5
  • 12
    • 0034598998 scopus 로고    scopus 로고
    • Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region
    • Hoyne, P. A., Elleman, T. C., Adams, T. E., Richards, K. M. and Ward, C. W. (2000) Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region. FEBS Lett. 469, 57-60
    • (2000) FEBS Lett , vol.469 , pp. 57-60
    • Hoyne, P.A.1    Elleman, T.C.2    Adams, T.E.3    Richards, K.M.4    Ward, C.W.5
  • 13
    • 0025009815 scopus 로고
    • The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity: Evidence from receptor chimeras
    • Gustafson, T. A. and Rutter, W. J. (1990) The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity: evidence from receptor chimeras. J. Biol. Chem. 265, 18663-18667
    • (1990) J. Biol. Chem , vol.265 , pp. 18663-18667
    • Gustafson, T.A.1    Rutter, W.J.2
  • 15
    • 5044227353 scopus 로고    scopus 로고
    • Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR
    • Denley, A., Bonython, E. R., Booker, G. W., Cosgrove, L. J., Forbes, B. E., Ward, C. W. and Wallace, J. C. (2004) Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR. Mol. Endocrinol. 18, 2502-2512
    • (2004) Mol. Endocrinol , vol.18 , pp. 2502-2512
    • Denley, A.1    Bonython, E.R.2    Booker, G.W.3    Cosgrove, L.J.4    Forbes, B.E.5    Ward, C.W.6    Wallace, J.C.7
  • 16
    • 0027960567 scopus 로고
    • Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the α-subunit of the insulin receptor: Identification of a new insulin-binding domain in the insulin receptor
    • Kurose, T., Pashmforoush, M., Yoshimasa, Y., Carroll, R., Schwartz, G. P., Burke, G. T., Katsoyannis, P. G. and Steiner, D. F. (1994) Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the α-subunit of the insulin receptor: identification of a new insulin-binding domain in the insulin receptor. J. Biol. Chem. 269, 29190-29197
    • (1994) J. Biol. Chem , vol.269 , pp. 29190-29197
    • Kurose, T.1    Pashmforoush, M.2    Yoshimasa, Y.3    Carroll, R.4    Schwartz, G.P.5    Burke, G.T.6    Katsoyannis, P.G.7    Steiner, D.F.8
  • 17
    • 19944363834 scopus 로고    scopus 로고
    • Wan, Z., Xu, B., Huang, K., Chu, Y. C., Li, B., Nakagawa, S. H., Qu, Y., Hu, S. Q., Katsoyannis, P. G. and Weiss, M. A. (2004) Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry 43, 16119-16133
    • Wan, Z., Xu, B., Huang, K., Chu, Y. C., Li, B., Nakagawa, S. H., Qu, Y., Hu, S. Q., Katsoyannis, P. G. and Weiss, M. A. (2004) Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry 43, 16119-16133
  • 18
    • 3142579218 scopus 로고    scopus 로고
    • Diabetes-associated mutations in insulin: Consecutive residues in the B chain contact distinct domains of the insulin receptor
    • Xu, B., Hu, S. Q., Chu, Y. C., Huang, K., Nakagawa, S. H., Whittaker, J., Katsoyannis, P. G. and Weiss, M. A. (2004) Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor. Biochemistry 43, 8356-8372
    • (2004) Biochemistry , vol.43 , pp. 8356-8372
    • Xu, B.1    Hu, S.Q.2    Chu, Y.C.3    Huang, K.4    Nakagawa, S.H.5    Whittaker, J.6    Katsoyannis, P.G.7    Weiss, M.A.8
  • 21
    • 33751029596 scopus 로고    scopus 로고
    • Production and characterisation of monoclonal antibodies against insulin-like growth factor type 1 receptor (IGF-1R)
    • Keyhanfar, M., Forbes, B. E., Cosgrove, L. J., Wallace, J. C. and Booker, G. W. (2006) Production and characterisation of monoclonal antibodies against insulin-like growth factor type 1 receptor (IGF-1R). Hybridoma 25, 230-237
    • (2006) Hybridoma , vol.25 , pp. 230-237
    • Keyhanfar, M.1    Forbes, B.E.2    Cosgrove, L.J.3    Wallace, J.C.4    Booker, G.W.5
  • 22
    • 0027366338 scopus 로고
    • Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor
    • Sell, C., Rubini, M., Rubin, R., Liu, J. P., Efstratiadis, A. and Baserga, R. (1993) Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl. Acad. Sci. U.S.A. 90, 11217-11221
    • (1993) Proc. Natl. Acad. Sci. U.S.A , vol.90 , pp. 11217-11221
    • Sell, C.1    Rubini, M.2    Rubin, R.3    Liu, J.P.4    Efstratiadis, A.5    Baserga, R.6
  • 23
    • 0026038883 scopus 로고
    • Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors
    • Schumacher, R., Mosthaf, L., Schlessinger, J., Brandenburg, D. and Ullrich, A. (1991) Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors. J. Biol. Chem. 266, 19288-19295
    • (1991) J. Biol. Chem , vol.266 , pp. 19288-19295
    • Schumacher, R.1    Mosthaf, L.2    Schlessinger, J.3    Brandenburg, D.4    Ullrich, A.5
  • 24
    • 0027471973 scopus 로고
    • Signaling-competent receptor chimaeras allow mapping of major insulin receptor binding domain determinants
    • Schumacher, R., Soos, M. A., Schlessinger, J., Brandenburg, D., Siddle, K. and Ullrich, A. (1993) Signaling-competent receptor chimaeras allow mapping of major insulin receptor binding domain determinants. J. Biol. Chem. 268, 1087-1094
    • (1993) J. Biol. Chem , vol.268 , pp. 1087-1094
    • Schumacher, R.1    Soos, M.A.2    Schlessinger, J.3    Brandenburg, D.4    Siddle, K.5    Ullrich, A.6
  • 25
  • 26
    • 0036186637 scopus 로고    scopus 로고
    • Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis
    • Forbes, B. E., Hartfield, P. J., McNeil, K. A., Surinya, K. H., Milner, S. J., Cosgrove, L. J. and Wallace, J. C. (2002) Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis. Eur. J. Biochem. 269, 961-968
    • (2002) Eur. J. Biochem , vol.269 , pp. 961-968
    • Forbes, B.E.1    Hartfield, P.J.2    McNeil, K.A.3    Surinya, K.H.4    Milner, S.J.5    Cosgrove, L.J.6    Wallace, J.C.7
  • 27
    • 0026632363 scopus 로고
    • A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity
    • Soos, M. A., Field, C. E., Lammers, R., Ullrich, A., Zhang, B., Roth, R. A., Andersen, A. S., Kjeldsen, T. and Siddle, K. (1992) A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity. J. Biol. Chem. 267, 12955-12963
    • (1992) J. Biol. Chem , vol.267 , pp. 12955-12963
    • Soos, M.A.1    Field, C.E.2    Lammers, R.3    Ullrich, A.4    Zhang, B.5    Roth, R.A.6    Andersen, A.S.7    Kjeldsen, T.8    Siddle, K.9
  • 28
    • 0022194320 scopus 로고
    • Human IgG1 and its Fc fragment bind with different affinities to the Fc receptors on the humah U937, HL-60 and ML-1 cell lines
    • Raychaudhuri, G., McCool, D. and Painter, R. H. (1985) Human IgG1 and its Fc fragment bind with different affinities to the Fc receptors on the humah U937, HL-60 and ML-1 cell lines. Mol. Immunol. 22, 1009-1019
    • (1985) Mol. Immunol , vol.22 , pp. 1009-1019
    • Raychaudhuri, G.1    McCool, D.2    Painter, R.H.3
  • 30
    • 0030756092 scopus 로고    scopus 로고
    • Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors: Insights into mechanisms of ligand binding
    • Mynarcik, D. C., Williams, P. F., Schaffer, L., Yu, G. Q. and Whittaker, J. (1997) Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors: insights into mechanisms of ligand binding. J. Biol. Chem. 272, 18650-18655
    • (1997) J. Biol. Chem , vol.272 , pp. 18650-18655
    • Mynarcik, D.C.1    Williams, P.F.2    Schaffer, L.3    Yu, G.Q.4    Whittaker, J.5
  • 31
    • 0027499070 scopus 로고
    • The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity
    • Crouch, S. P., Kozlowski, R., Slater, K. J. and Fletcher, J. (1993) The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. J. Immunol. Methods 160, 81-88
    • (1993) J. Immunol. Methods , vol.160 , pp. 81-88
    • Crouch, S.P.1    Kozlowski, R.2    Slater, K.J.3    Fletcher, J.4
  • 33
    • 0038380346 scopus 로고    scopus 로고
    • Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells
    • Hailey, J., Maxwell, E., Koukouras, K., Bishop, W. R., Pachter, J. A. and Wang, Y. (2002) Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells. Mol. Cancer Ther. 1, 1349-1353
    • (2002) Mol. Cancer Ther , vol.1 , pp. 1349-1353
    • Hailey, J.1    Maxwell, E.2    Koukouras, K.3    Bishop, W.R.4    Pachter, J.A.5    Wang, Y.6
  • 34
    • 0029060529 scopus 로고
    • Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor
    • Ward, C. W., Hoyne, P. A. and Flegg, R. H. (1995) Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor Proteins 22, 141-153
    • (1995) Proteins , vol.22 , pp. 141-153
    • Ward, C.W.1    Hoyne, P.A.2    Flegg, R.H.3
  • 35
    • 0036420965 scopus 로고    scopus 로고
    • Molecular recognition in antibody-antigen complexes
    • Sundberg, E. J. and Mariuzza, R. A. (2002) Molecular recognition in antibody-antigen complexes. Adv. Protein Chem. 61, 119-160
    • (2002) Adv. Protein Chem , vol.61 , pp. 119-160
    • Sundberg, E.J.1    Mariuzza, R.A.2
  • 36
    • 0028342955 scopus 로고
    • Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity
    • Zhang, W., Gustafson, T. A., Rutter, W. J. and Johnson, J. D. (1994) Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity. J. Biol. Chem. 269, 10609-10613
    • (1994) J. Biol. Chem , vol.269 , pp. 10609-10613
    • Zhang, W.1    Gustafson, T.A.2    Rutter, W.J.3    Johnson, J.D.4
  • 37
    • 0032544407 scopus 로고    scopus 로고
    • The insulin-like growth factor (IGF) binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis
    • Jansson, M., Andersson, G., Uhlen, M., Nilsson, B. and Kordel, J. (1998) The insulin-like growth factor (IGF) binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis. J. Biol. Chem. 273, 24701-24707
    • (1998) J. Biol. Chem , vol.273 , pp. 24701-24707
    • Jansson, M.1    Andersson, G.2    Uhlen, M.3    Nilsson, B.4    Kordel, J.5
  • 38
    • 0025113224 scopus 로고
    • The roles of tyroslnes 24, 31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor
    • Bayne, M. L., Applebaum, J., Chicchi, G. G., Miller, R. E. and Cascieri, M. A. (1990) The roles of tyroslnes 24, 31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor. J. Biol. Chem. 265, 15648-15652
    • (1990) J. Biol. Chem , vol.265 , pp. 15648-15652
    • Bayne, M.L.1    Applebaum, J.2    Chicchi, G.G.3    Miller, R.E.4    Cascieri, M.A.5
  • 39
    • 33745929892 scopus 로고    scopus 로고
    • Model for the complex between the insulin-like growth factor I and its receptor: Towards designing antagonists for the IGF-1 receptor
    • Epa, V. C. and Ward, C. W. (2006) Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor. Protein Eng. Des. Sel. 19, 377-384
    • (2006) Protein Eng. Des. Sel , vol.19 , pp. 377-384
    • Epa, V.C.1    Ward, C.W.2
  • 40
    • 9144256621 scopus 로고    scopus 로고
    • Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody
    • Lu, D., Zhang, H., Ludwig, D., Persaud, A., Jimenez, X., Burtrum, D., Balderes, P., Liu, M., Bohlen, P., Witte, L. and Zhu, Z. (2004) Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody. J. Biol. Chem. 279, 2856-2865
    • (2004) J. Biol. Chem , vol.279 , pp. 2856-2865
    • Lu, D.1    Zhang, H.2    Ludwig, D.3    Persaud, A.4    Jimenez, X.5    Burtrum, D.6    Balderes, P.7    Liu, M.8    Bohlen, P.9    Witte, L.10    Zhu, Z.11
  • 41
    • 21244441508 scopus 로고    scopus 로고
    • A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity
    • Lu, D., Zhang, H., Koo, H., Tonra, J., Balderes, P., Prewett, M., Corcoran, E., Mangalampalli, V., Bassi, R., Anselma, D. et al. (2005) A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity. J. Biol. Chem. 280, 19665-19672
    • (2005) J. Biol. Chem , vol.280 , pp. 19665-19672
    • Lu, D.1    Zhang, H.2    Koo, H.3    Tonra, J.4    Balderes, P.5    Prewett, M.6    Corcoran, E.7    Mangalampalli, V.8    Bassi, R.9    Anselma, D.10
  • 43
    • 0037308651 scopus 로고    scopus 로고
    • A chimaeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I
    • Sachdev, D., Li, S. L., Hartell, J. S., Fujita-Yamaguchi, Y., Miller, J. S. and Yee, D. (2003) A chimaeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res. 63, 627-635
    • (2003) Cancer Res , vol.63 , pp. 627-635
    • Sachdev, D.1    Li, S.L.2    Hartell, J.S.3    Fujita-Yamaguchi, Y.4    Miller, J.S.5    Yee, D.6
  • 44
    • 10344247119 scopus 로고    scopus 로고
    • A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts
    • Goetsch, L., Gonzalez, A., Leger, O., Beck, A., Pauwels, P. J., Haeuw, J. F. and Corvaia, N. (2005) A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int. J. Cancer. 113, 316-328
    • (2005) Int. J. Cancer , vol.113 , pp. 316-328
    • Goetsch, L.1    Gonzalez, A.2    Leger, O.3    Beck, A.4    Pauwels, P.J.5    Haeuw, J.F.6    Corvaia, N.7


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