Novel role of the IGF-1 receptor in endothelial function and repair: Studies in endothelium-targeted IGF-1 receptor transgenic mice

Diabetes

Volumn 61, Issue 9, 2012, Pages 2359-2368

  Imrie, Helen ^a   Viswambharan, Hema ^a   Sukumar, Piruthivi ^a   Abbas, Afroze ^a   Cubbon, Richard M ^a   Yuldasheva, Nadira ^a   Gage, Matthew ^a   Smith, Jessica ^a   Galloway, Stacey ^a   Skromna, Anna ^a   Rashid, Sheik Taqweer ^a   Futers, T Simon ^a   Xuan, Shouhong ^b   Gatenby, V Kate ^a   Grant, Peter J ^a   Channon, Keith M ^c   Beech, David J ^a   Wheatcroft, Stephen B ^a   Kearney, Mark T ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b Howard Hughes Medical Institute   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ANGIOPOIETIN RECEPTOR; INSULIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIAL PRESSURE; ARTERY INJURY; ARTICLE; BIOAVAILABILITY; CELL MIGRATION; CELL REGENERATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; FEMALE; GLUCOSE HOMEOSTASIS; HOMEOSTASIS; INSULIN SENSITIVITY; MALE; METABOLIC PARAMETERS; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SYSTOLIC BLOOD PRESSURE;

ANIMALS; AORTA; BLOOD GLUCOSE; BLOOD PRESSURE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HOMEOSTASIS; HUMANS; MALE; MICE; MICE, TRANSGENIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RECEPTOR, IGF TYPE 1; VASOCONSTRICTION;

EID: 84865487544     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1494     Document Type: Article

References (37)

1. Razani B, Semenkovich CF. Getting away from glucose: stop sugarcoating diabetes. Nat Med 2009;15:372-373
2. Booth GL, Kapral MK, Fung K, Tu JV. Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet 2006;368:29-36 (Pubitemid 43947203)
3. Marso SP, Hiatt WR. Peripheral arterial disease in patients with diabetes. J Am Coll Cardiol 2006;47:921-929
4. Stegmayr B, Asplund K. Diabetes as a risk factor for stroke. A population perspective. Diabetologia 1995;38:1061-1068
5. Reiber GE, Boyko EJ, Smith DG. Lower extremity foot ulcers and amputations in diabetes. In Diabetes in America. Harris MI, Stern MP, Eds. Bethesda, Maryland, U.S. Government Printing Office, 1995, p. 409-428
6. Kempen JH, O'Colmain BJ, Leske MC, et al.; Eye Diseases Prevalence Research Group. The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol 2004;122:552-563 (Pubitemid 38456292)
7. Nakagawa T, Kosugi T, Haneda M, Rivard CJ, Long DA. Abnormal angiogenesis in diabetic nephropathy. Diabetes 2009;58:1471-1478
8. Muniyappa R, Montagnani M, Koh KK, Quon MJ. Cardiovascular actions of insulin. Endocr Rev 2007;28:463-491 (Pubitemid 47236334)
9. Wheatcroft SB, Shah AM, Li JM, et al. Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor. Diabetes 2004;53:2645-2652 (Pubitemid 39299274)
10. Kahn MB, Yuldasheva NY, Cubbon RM, et al. Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration. Diabetes 2011;60:1295-1303
11. Duncan ER, Crossey PA, Walker S, et al. Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes 2008;57:3307-3314
12. De Meyts P, Whittaker J. Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Disc 2002;1:769-783 (Pubitemid 37361561)
13. Slaaby R, Schäffer L, Lautrup-Larsen I, et al. Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. J Biol Chem 2006;281:25869-25874 (Pubitemid 44401792)
14. Gatenby V, Kearney MT. Targeting vascular IGF-1 resistance in obesity and type 2 diabetes mellitus. Expert Opin Ther Targets 2010;14:1333-1342
15. Abbas A, Imrie H, Viswambharan H, et al. The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes 2011;60:2169-2178
16. Guillot PV, Liu L, Kuivenhoven JA, Guan J, Rosenberg RD, Aird WC. Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics 2000;2:77-83
17. Minami T, Kuivenhoven JA, Evans V, Kodama T, Rosenberg RD, Aird WC. Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice. Arterioscler Thromb Vasc Biol 2003;23:2041-2047 (Pubitemid 37433198)
18. Bendall JK, Rinze R, Adlam D, et al. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circ Res 2007;100:1016-1025 (Pubitemid 46598926)
19. Li S, Ferber A, Miura M, Baserga R. Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. J Biol Chem 1994;269:32558-32564
20. Imrie H, Abbas A, Viswambharan H, et al. Vascular insulin-like growth factor-I resistance and diet-induced obesity. Endocrinology 2009;150:4575-4582
21. Rajwani A, Ezzat V, Smith J, et al. Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis. Diabetes 2012;61:915-924
22. Seddon M, Melikian N, Dworakowski R, et al. Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo. Circulation 2009;119:2656-2662
23. Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation 2004;109:2518-2523 (Pubitemid 38720550)
24. Chen J, Kuhlencordt PJ, Astern J, Gyurko R, Huang PL. Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation 2001;104:2391-2394 (Pubitemid 33108369)
25. Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399:597-601
26. Atochin DN, Wang A, Liu VW, et al. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest 2007;117:1961-1967 (Pubitemid 47036330)
27. Schleicher M, Yu J, Murata T, et al. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal 2009;2:ra41
28. Jiang ZY, Lin YW, Clemont A, et al. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 1999;104:447-457 (Pubitemid 29534329)
29. Federici M, Porzio O, Zucaro L, et al. Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients. Mol Cell Endocrinol 1997;135:41-47 (Pubitemid 28010412)
30. Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 1991;351:714-718 (Pubitemid 21896670)
31. Kubota T, Kubota N, Kumagai H, et al. Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab 2011;13:294-307
32. Vicent D, Ilany J, Kondo T, et al. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest 2003;111:1373-1380 (Pubitemid 36554708)
33. Cubbon RM, Ali N, Sengupta A, Kearney MT. Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus. Curr Vasc Pharmacol 2012;10:271-284
34. Itoh Y, Toriumi H, Yamada S, Hoshino H, Suzuki N. Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion. Arterioscler Thromb Vasc Biol 2010;30:1725-1732
35. Cubbon RM, Murgatroyd SR, Ferguson C, et al. Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men. Arterioscler Thromb Vasc Biol 2010;30:878-884
36. Thum T, Hoeber S, Froese S, et al. Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1. Circ Res 2007;100:434-443
37. Sukhanov S, Higashi Y, Shai SY, et al. IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 2007;27:2684-2690 (Pubitemid 350158923)