Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Shimazu, Tadahiro ^a   Barjau, Joaquin ^a   Sohtome, Yoshihiro ^a   Sodeoka, Mikiko ^a   Shinkai, Yoichi ^a  

^a RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELONGATION FACTOR 1ALPHA; HEAT SHOCK PROTEIN 70; HISTONE LYSINE METHYLTRANSFERASE; HISTONE LYSINE METHYLTRANSFERASE METTL10; PROPARGYLIC SELENIUM ADENOSYLSELENOMETHIONINE; PROTEIN LYSINE METHYLTRANSFERASE METTL21A; S ADENOSYLMETHIONINE; SELENIUM; SELENOMETHIONINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALKYLATION; ANALYTIC METHOD; ARTICLE; CELL LABELING; CELL LYSATE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE SILENCING; HISTONE METHYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MAMMAL CELL; MOLECULAR PROBE; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEOMICS; QUANTITATIVE STUDY; SYNTHESIS; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; FLUORESCENCE MICROSCOPY; HEK293 CELL LINE; MASS SPECTROMETRY; METABOLISM;

ANIMALS; HEK293 CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; MICROSCOPY, FLUORESCENCE; S-ADENOSYLMETHIONINE; SELENIUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84920513122     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105394     Document Type: Article

References (45)

1. Tollervey JR, Lunyak VV (2012) Epigenetics: judge, jury and executioner of stem cell fate. Epigenetics: official journal of the DNA Methylation Society 7: 823-840.
2. Tsai HC, Baylin SB (2011) Cancer epigenetics: linking basic biology to clinical medicine. Cell research 21: 502-517.
3. Greer EL, Shi Y (2012) Histone methylation: a dynamic mark in health, disease and inheritance. Nature reviews Genetics 13: 343-357.
4. Cao XJ, Arnaudo AM, Garcia BA (2013) Large-scale global identification of protein lysine methylation in vivo. Epigenetics: official journal of the DNA Methylation Society 8: 477-485.
5. Guo A, Gu H, Zhou J, Mulhern D, Wang Y, et al. (2013) Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation. Molecular & cellular proteomics: MCP.
6. Moore KE, Carlson SM, Camp ND, Cheung P, James RG, et al. (2013) A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Molecular cell 50: 444-456.
7. Carlson SM, Moore KE, Green EM, Martin GM, Gozani O (2014) Proteomewide enrichment of proteins modified by lysine methylation. Nature protocols 9: 37-50.
8. Bothwell IR, Islam K, Chen Y, Zheng W, Blum G, et al. (2012) Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation. Journal of the American Chemical Society 134: 14905-14912.
9. Willnow S, Martin M, Luscher B, Weinhold E (2012) A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases. Chembiochem: a European journal of chemical biology 13: 1167-1173.
10. Binda O, Boyce M, Rush JS, Palaniappan KK, Bertozzi CR, et al. (2011) A chemical method for labeling lysine methyltransferase substrates. Chembiochem: a European journal of chemical biology 12: 330-334.
11. Wang R, Luo M (2013) A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells. Current opinion in chemical biology 17: 729-737.
12. Chang PV, Chen X, Smyrniotis C, Xenakis A, Hu T, et al. (2009) Metabolic labeling of sialic acids in living animals with alkynyl sugars. Angew Chem Int Ed Engl 48: 4030-4033.
13. Yang YY, Ascano JM, Hang HC (2010) Bioorthogonal chemical reporters for monitoring protein acetylation. Journal of the American Chemical Society 132: 3640-3641.
14. Martin BR, Cravatt BF (2009) Large-scale profiling of protein palmitoylation in mammalian cells. Nature methods 6: 135-138.
15. Charron G, Zhang MM, Yount JS, Wilson J, Raghavan AS, et al. (2009) Robust fluorescent detection of protein fatty-acylation with chemical reporters. Journal of the American Chemical Society 131: 4967-4975.
16. Hang HC, Wilson JP, Charron G (2011) Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking. Accounts of chemical research 44: 699-708.
17. Petrossian TC, Clarke SG (2011) Uncovering the human methyltransferasome. Molecular & cellular proteomics: MCP 10: M110 000976.
18. Clarke SG (2013) Protein methylation at the surface and buried deep: thinking outside the histone box. Trends in biochemical sciences 38: 243-252.
19. Huang J, Dorsey J, Chuikov S, Perez-Burgos L, Zhang X, et al. (2010) G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem 285: 9636-9641.
20. Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, et al. (2006) Repression of p53 activity by Smyd2-mediated methylation. Nature 444: 629-632. (Pubitemid 44864441)
21. Abu-Farha M, Lanouette S, Elisma F, Tremblay V, Butson J, et al. (2011) Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2. Journal of molecular cell biology 3: 301-308.
22. Cho HS, Shimazu T, Toyokawa G, Daigo Y, Maehara Y, et al. (2012) Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nature communications 3: 1072.
23. Kernstock S, Davydova E, Jakobsson M, Moen A, Pettersen S, et al. (2012) Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nature communications 3: 1038.
24. Cloutier P, Lavallee-Adam M, Faubert D, Blanchette M, Coulombe B (2013) A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS genetics 9: e1003210.
25. Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, et al. (2013) Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. J Biol Chem 288: 27752-27763.
26. Magnani R, Dirk LM, Trievel RC, Houtz RL (2010) Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nature communications 1: 43.
27. Lipson RS, Webb KJ, Clarke SG (2010) Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Archives of biochemistry and biophysics 500: 137-143.
28. Couttas TA, Raftery MJ, Padula MP, Herbert BR, Wilkins MR (2012) Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases. Proteomics 12: 960-972.
29. Tachibana M, Sugimoto K, Fukushima T, Shinkai Y (2001) Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J Biol Chem 276: 25309-25317.
30. Matsui T, Leung D, Miyashita H, Maksakova IA, Miyachi H, et al. (2010) Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature 464: 927-931.
31. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, et al. (2005) The transcriptional landscape of the mammalian genome. Science 309: 1559-1563.
32. Donlin LT, Andresen C, Just S, Rudensky E, Pappas CT, et al. (2012) Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes & development 26: 114-119.
33. Dever TE, Costello CE, Owens CL, Rosenberry TL, Merrick WC (1989) Location of seven post-translational modifications in rabbit elongation factor 1 alpha including dimethyllysine, trimethyllysine, and glycerylphosphorylethanolamine. J Biol Chem 264: 20518-20525. (Pubitemid 20009242)
34. Cavallius J, Zoll W, Chakraburtty K, Merrick WC (1993) Characterization of yeast EF-1 alpha: non-conservation of post-translational modifications. Biochimica et biophysica acta 1163: 75-80. (Pubitemid 23116032)
35. Grosshans H, Simos G, Hurt E (2000) Review: transport of tRNA out of the nucleus-direct channeling to the ribosome? Journal of structural biology 129: 288-294. (Pubitemid 30481370)
36. Chuang SM, Chen L, Lambertson D, Anand M, Kinzy TG, et al. (2005) Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A. Molecular and cellular biology 25: 403-413. (Pubitemid 40039829)
37. Gross SR, Kinzy TG (2007) Improper organization of the actin cytoskeleton affects protein synthesis at initiation. Molecular and cellular biology 27: 1974-1989.
38. Blackwell JL, Brinton MA (1997) Translation elongation factor-1 alpha interacts with the 3′ stem-loop region of West Nile virus genomic RNA. Journal of virology 71: 6433-6444. (Pubitemid 27355297)
39. Blumenthal T, Young RA, Brown S (1976) Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits. J Biol Chem 251: 2740-2743.
40. Brinton MA (2001) Host factors involved in West Nile virus replication. Annals of the New York Academy of Sciences 951: 207-219. (Pubitemid 34060046)
41. Nishikiori M, Dohi K, Mori M, Meshi T, Naito S, et al. (2006) Membrane-bound tomato mosaic virus replication proteins participate in RNA synthesis and are associated with host proteins in a pattern distinct from those that are not membrane bound. Journal of virology 80: 8459-8468. (Pubitemid 44384858)
42. Mateyak MK, Kinzy TG (2010) eEF1A: thinking outside the ribosome. J Biol Chem 285: 21209-21213.
43. Li Z, Gonzalez PA, Sasvari Z, Kinzy TG, Nagy PD (2014) Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants. Virology 448: 43-54.
44. Vermillion KL, Lidberg KA, Gammill LS (2014) Cytoplasmic protein methylation is essential for neural crest migration. The Journal of cell biology 204: 95-109.
45. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Molecular biology and evolution 30: 2725-2729.