Lysine methylation of VCP by a member of a novel human protein methyltransferase family

Nature Communications

Volumn 3, Issue , 2012, Pages

  Kernstock, Stefan ^a   Davydova, Erna ^a   Jakobsson, Magnus ^a   Moen, Anders ^a   Pettersen, Solveig ^b   Mælandsmo, Gunhild M ^b   Egge Jacobsen, Wolfgang ^a   Falnes, Pål O ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; HISTONE LYSINE METHYLTRANSFERASE; VALOSIN CONTAINING PROTEIN; ZINC FINGER NUCLEASE;

ARTICLE; BIOCHEMISTRY; BIOINFORMATICS; CELL INVASION; CELL LINE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GROWTH RATE; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; METASTASIS; TISSUES;

ADENOSINE TRIPHOSPHATASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; CELL LINE; HUMANS; LYSINE; METHYLATION; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; SEQUENCE ALIGNMENT;

EUKARYOTA; MAMMALIA;

EID: 84867018639     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2041     Document Type: Article

References (34)

1. Walsh, C. Posttranslational Modification Of Proteins: Expanding Nature's Inventory (Roberts and Co., 2006).
2. Petrossian, T. C. & Clarke, S. G. Uncovering the human methyltransferasome. Mol. Cell. Proteomics 10: M110000976 (2011).
3. Feng, Q. et al. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr. Biol. 12, 1052-1058 (2002). (Pubitemid 34703339)
4. Magnani, R., Dirk, L. M., Trievel, R. C. & Houtz, R. L. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nat. Commun. 1, 43 (2010).
5. Lipson, R. S., Webb, K. J. & Clarke, S. G. Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 500, 137-143 (2010).
6. Egorova, K. S., Olenkina, O. M. & Olenina, L. V. Lysine methylation of nonhistone proteins is a way to regulate their stability and function. Biochemistry 75, 535-548 (2010).
7. Chapman, E., Fry, A. N. & Kang, M. The complexities of p97 function in health and disease. Mol. Biosys. 7, 700-710 (2011).
8. DeLaBarre, B. & Brunger, A. T. Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat. Struct. Biol. 10, 856-863 (2003). (Pubitemid 37187659)
9. Yamanaka, K., Sasagawa, Y. & Ogura, T. Recent advances in p97/VCP/Cdc48 cellular functions. Biochim. Biophys. Acta 1823, 130-137 (2012).
10. Kimonis, V. E., Fulchiero, E., Vesa, J. & Watts, G. VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder. Biochim. Biophys. Acta 1782, 744-748 (2008).
11. Thiele, W. et al. Discovery of a novel tumour metastasis-promoting gene, NVM-1. J. Pathol. 225, 96-105 (2011).
12. Katz, J. E., Dlakic, M. & Clarke, S. Automated identification of putative methyltransferases from genomic open reading frames. Mol. Cell. Proteomics 2, 525-540 (2003).
13. Ye, Y., Meyer, H. H. & Rapoport, T. A. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J. Cell Biol. 162, 71-84 (2003). (Pubitemid 36859536)
14. Wang, Q., Song, C., Yang, X. & Li, C. C. D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP. J. Biol. Chem. 278, 32784-32793 (2003). (Pubitemid 37055719)
15. Frederiks, F. et al. Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states. Nat. Struct. Mol. Biol. 15, 550-557 (2008). (Pubitemid 351799139)
16. Petrossian, T. C. & Clarke, S. G. Multiple motif scanning to identify methyltransferases from the yeast proteome. Mol. Cell. Proteomics 8, 1516-1526 (2009).
17. Martin, J. L. & McMillan, F. M. SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold. Curr. Opin. Struct. Biol. 12, 783-793 (2002). (Pubitemid 36009496)
18. Bec, G., Kerjan, P. & Waller, J. P. Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. J. Biol. Chem. 269, 2086-2092 (1994).
19. Webb, K. J. et al. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. J. Biol. Chem. 285, 37598-37606 (2010).
20. Schubert, H. L., Blumenthal, R. M. & Cheng, X. Many paths to methyltransfer: a chronicle of convergence. Trends Biochem. Sci. 28, 329-335 (2003). (Pubitemid 36776296)
21. Thomas, P. D. et al. PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Nucleic Acids Res. 31, 334-341 (2003). (Pubitemid 36150398)
22. Rathert, P. et al. Protein lysine methyltransferase G9a acts on non-histone targets. Nat. Chem. Biol. 4, 344-346 (2008). (Pubitemid 351693993)
23. Frankel, A. et al. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J. Biol. Chem. 277, 3537-3543 (2002). (Pubitemid 34953224)
24. Sayegh, J., Webb, K., Cheng, D., Bedford, M. T. & Clarke, S. G. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J. Biol. Chem. 282, 36444-36453 (2007).
25. Braun, R. J. & Zischka, H. Mechanisms of Cdc48/VCP-mediated cell death: from yeast apoptosis to human disease. Biochim. Biophys. Acta 1783, 1418-1435 (2008).
26. DeLaBarre, B., Christianson, J. C., Kopito, R. R. & Brunger, A. T. Central pore residues mediate the p97/VCP activity required for ERAD. Mol. Cell 22, 451-462 (2006).
27. Ramadan, K. et al. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature 450, 1258-1262 (2007).
28. Songe-Moller, L. et al. Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. Mol. Cell. Biol. 30, 1814-1827 (2010).
29. Graslund, S. et al. Protein production and purification. Nat. Methods 5, 135-146 (2008).
30. Egge-Jacobsen, W. et al. O-linked glycosylation of the PilA Pilin protein of Francisella tularensis: identification of the endogenous protein-targeting oligosaccharyltransferase and characterization of the native oligosaccharide. J. Bacteriol. 193, 5487-5497 (2011).
31. Cox, J. & Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 26, 1367-1372 (2008).
32. Harlow, E. & Lane, D. Using Antibodies: A Laboratory Manual (Cold Spring Harbour Laboratory Press, 1999).
33. Berge, G. et al. Osteopontin-an important downstream effector of S100A4-mediated invasion and metastasis. Int. J. Cancer 129, 780-790 (2011).
34. Dignam, J. D. Preparation of extracts from higher eukaryotes. Methods Enzymol. 182, 194-203 (1990).