-
1
-
-
84871712509
-
Protein arginine methyltransferases and cancer
-
Yang Y., Bedford MT: Protein arginine methyltransferases and cancer. Nat Rev Cancer 2013, 13:37-50.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 37-50
-
-
Yang, Y.1
Bedford, MT.2
-
2
-
-
84858636152
-
Current chemical biology approaches to interrogate protein methyltransferases
-
Luo M: Current chemical biology approaches to interrogate protein methyltransferases. ACS Chem Biol 2012, 7:443-463.
-
(2012)
ACS Chem Biol
, vol.7
, pp. 443-463
-
-
Luo, M.1
-
3
-
-
69949148388
-
Protein methyltransferases as a target class for drug discovery
-
Copeland R.A., Solomon M.E., Richon VM: Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov 2009, 8:724-732.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 724-732
-
-
Copeland, R.A.1
Solomon, M.E.2
Richon, V.M.3
-
4
-
-
70349780606
-
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors
-
Spannhoff A., Hauser A.T., Heinke R., Sippl W., Jung M: The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors. Chemmedchem 2009, 4:1568-1582.
-
(2009)
Chemmedchem
, vol.4
, pp. 1568-1582
-
-
Spannhoff, A.1
Hauser, A.T.2
Heinke, R.3
Sippl, W.4
Jung, M.5
-
5
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides T: Chromatin modifications and their function. Cell 2007, 128:693-705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
6
-
-
33847032959
-
SnapShot: histone-modifying enzymes
-
Kouzarides T. SnapShot: histone-modifying enzymes. Cell 2007, 128:802-803.
-
(2007)
Cell
, vol.128
, pp. 802-803
-
-
Kouzarides, T.1
-
7
-
-
77954265666
-
Negative regulation of hypoxic responses via induced reptin methylation
-
Lee J.S., Kim Y., Kim I.S., Kim B., Choi H.J., Lee J.M., Shin H.J.R., Kim J.H., Kim J.Y., Seo S.B., et al. Negative regulation of hypoxic responses via induced reptin methylation. Mol Cell 2010, 39:71-85.
-
(2010)
Mol Cell
, vol.39
, pp. 71-85
-
-
Lee, J.S.1
Kim, Y.2
Kim, I.S.3
Kim, B.4
Choi, H.J.5
Lee, J.M.6
Shin, H.J.R.7
Kim, J.H.8
Kim, J.Y.9
Seo, S.B.10
-
8
-
-
73149099403
-
Regulation of NF-kappa B activity through lysine monomethylation of p65
-
Ea C.K., Baltimore D: Regulation of NF-kappa B activity through lysine monomethylation of p65. Proc Acad Natl Sci U S A 2009, 106:18972-18977.
-
(2009)
Proc Acad Natl Sci U S A
, vol.106
, pp. 18972-18977
-
-
Ea, C.K.1
Baltimore, D.2
-
9
-
-
55549140173
-
Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation
-
Li Y., Reddy M.A., Miao F., Shanmugam N., Yee J.K., Hawkins D., Ren B., Natarajan R: Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem 2008, 283:26771-26781.
-
(2008)
J Biol Chem
, vol.283
, pp. 26771-26781
-
-
Li, Y.1
Reddy, M.A.2
Miao, F.3
Shanmugam, N.4
Yee, J.K.5
Hawkins, D.6
Ren, B.7
Natarajan, R.8
-
10
-
-
72849152508
-
CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation
-
Wu Q., Bruce A.W., Jedrusik A., Ellis P.D., Andrews R.M., Langford C.F., Glover D.M., Zernicka-Goetz M: CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation. Stem Cells 2009, 27:2637-2645.
-
(2009)
Stem Cells
, vol.27
, pp. 2637-2645
-
-
Wu, Q.1
Bruce, A.W.2
Jedrusik, A.3
Ellis, P.D.4
Andrews, R.M.5
Langford, C.F.6
Glover, D.M.7
Zernicka-Goetz, M.8
-
11
-
-
80055026231
-
CARM1 mediates modulation of Sox2
-
Zhao H.Y., Zhang Y.J., Dai H., Zhang Y., Shen Y.F. CARM1 mediates modulation of Sox2. PLoS ONE 2011, 6:e27026.
-
(2011)
PLoS ONE
, vol.6
-
-
Zhao, H.Y.1
Zhang, Y.J.2
Dai, H.3
Zhang, Y.4
Shen, Y.F.5
-
12
-
-
84866091538
-
Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions
-
Kawabe Y.I., Wang Y.X., McKinnell I.W., Bedford M.T., Rudnicki MA: Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell 2012, 11:333-345.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 333-345
-
-
Kawabe, Y.I.1
Wang, Y.X.2
McKinnell, I.W.3
Bedford, M.T.4
Rudnicki, MA.5
-
13
-
-
78650985680
-
An assessment of histone-modification antibody quality
-
Egelhofer T.A., Minoda A., Klugman S., Lee K., Kolasinska-Zwierz P., Alekseyenko A.A., Cheung M.-S., Day D.S., Gadel S., Gorchakov A.A., et al. An assessment of histone-modification antibody quality. Nat Struct Mol Biol 2011, 18:91-94.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 91-94
-
-
Egelhofer, T.A.1
Minoda, A.2
Klugman, S.3
Lee, K.4
Kolasinska-Zwierz, P.5
Alekseyenko, A.A.6
Cheung, M.-S.7
Day, D.S.8
Gadel, S.9
Gorchakov, A.A.10
-
14
-
-
80054815567
-
A proteomic approach for the identification of novel lysine methyltransferase substrates
-
Levy D., Liu C.L., Yang Z., Newman A.M., Alizadeh A.A., Utz P.J., Gozani O: A proteomic approach for the identification of novel lysine methyltransferase substrates. Epigenet Chromatin 2011, 4:19.
-
(2011)
Epigenet Chromatin
, vol.4
, pp. 19
-
-
Levy, D.1
Liu, C.L.2
Yang, Z.3
Newman, A.M.4
Alizadeh, A.A.5
Utz, P.J.6
Gozani, O.7
-
15
-
-
74049135429
-
A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex
-
Fritsch L., Robin P., Mathieu J.R.R., Souidi M., Hinaux H., Rougeulle C., Harel-Bellan A., Ameyar-Zazoua M., Ait-Si-Ali S: A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex. Mol Cell 2010, 37:46-56.
-
(2010)
Mol Cell
, vol.37
, pp. 46-56
-
-
Fritsch, L.1
Robin, P.2
Mathieu, J.R.R.3
Souidi, M.4
Hinaux, H.5
Rougeulle, C.6
Harel-Bellan, A.7
Ameyar-Zazoua, M.8
Ait-Si-Ali, S.9
-
16
-
-
0035965747
-
Design of allele-specific protein methyltransferase inhibitors
-
Lin Q., Jiang F.Y., Schultz P.G., Gray N.S. Design of allele-specific protein methyltransferase inhibitors. J Am Chem Soc 2001, 123:11608-11613.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 11608-11613
-
-
Lin, Q.1
Jiang, F.Y.2
Schultz, P.G.3
Gray, N.S.4
-
18
-
-
0034632829
-
Regulation of chromatin structure by site-specific histone H3 methyltransferases
-
Rea S., Eisenhaber F., O'Carroll N., Strahl B.D., Sun Z.W., Schmid M., Opravil S., Mechtler K., Ponting C.P., Allis C.D., et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 2000, 406:593-599.
-
(2000)
Nature
, vol.406
, pp. 593-599
-
-
Rea, S.1
Eisenhaber, F.2
O'Carroll, N.3
Strahl, B.D.4
Sun, Z.W.5
Schmid, M.6
Opravil, S.7
Mechtler, K.8
Ponting, C.P.9
Allis, C.D.10
-
19
-
-
59449087016
-
Histone modifying enzymes: Structures, mechanisms, and specificities
-
Marmorstein R., Trievel R.C. Histone modifying enzymes: Structures, mechanisms, and specificities. BiochimBiophys Acta 2009, 1789:58-68.
-
(2009)
BiochimBiophys Acta
, vol.1789
, pp. 58-68
-
-
Marmorstein, R.1
Trievel, R.C.2
-
20
-
-
79953187310
-
Structural chemistry of the histone methyltransferases cofactor binding site
-
Campagna-Slater V., Mok M.W., Nguyen K.T., Feher M., Najmanovich R., Schapira M. Structural chemistry of the histone methyltransferases cofactor binding site. J Chem Inf Model 2011, 51:612-623.
-
(2011)
J Chem Inf Model
, vol.51
, pp. 612-623
-
-
Campagna-Slater, V.1
Mok, M.W.2
Nguyen, K.T.3
Feher, M.4
Najmanovich, R.5
Schapira, M.6
-
21
-
-
80455125845
-
Structural chemistry of human SET domain protein methyltransferases
-
Schapira M. Structural chemistry of human SET domain protein methyltransferases. Curr Chem Genomics 2011, 5:85-94.
-
(2011)
Curr Chem Genomics
, vol.5
, pp. 85-94
-
-
Schapira, M.1
-
22
-
-
33847041833
-
A new tool for biotechnology: AdoMet-dependent methyltransferases
-
Klimasauskas S., Weinhold E: A new tool for biotechnology: AdoMet-dependent methyltransferases. Trends Biotechnol 2007, 25:99-104.
-
(2007)
Trends Biotechnol
, vol.25
, pp. 99-104
-
-
Klimasauskas, S.1
Weinhold, E.2
-
23
-
-
33947274509
-
Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG)
-
Lukinavicius G., Lapiene V., Stasevskij Z., Dalhoff C., Weinhold E., Klimasauskas S: Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG). J Am Chem Soc 2007, 129:2758-2759.
-
(2007)
J Am Chem Soc
, vol.129
, pp. 2758-2759
-
-
Lukinavicius, G.1
Lapiene, V.2
Stasevskij, Z.3
Dalhoff, C.4
Weinhold, E.5
Klimasauskas, S.6
-
24
-
-
33645240950
-
Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases
-
Dalhoff C., Lukinavicius G., Klimasauskas S., Weinhold E: Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases. Nat Chem Biol 2006, 2:31-32.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 31-32
-
-
Dalhoff, C.1
Lukinavicius, G.2
Klimasauskas, S.3
Weinhold, E.4
-
25
-
-
84871255735
-
Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA
-
Lukinavicius G., Lapinaite A., Urbanaviciute G., Gerasimaite R., Klimasauskas S: Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA. Nucl Acids Res 2012, 40:11594-11602.
-
(2012)
Nucl Acids Res
, vol.40
, pp. 11594-11602
-
-
Lukinavicius, G.1
Lapinaite, A.2
Urbanaviciute, G.3
Gerasimaite, R.4
Klimasauskas, S.5
-
26
-
-
73249149241
-
Biocatalytic Friedel-Crafts alkylation using non-natural cofactors
-
Stecher H., Tengg M., Ueberbacher B.J., Remler P., Schwab H., Griengl H., Gruber-Khadjawi M. Biocatalytic Friedel-Crafts alkylation using non-natural cofactors. Angew Chem Int Ed 2009, 48:9546-9548.
-
(2009)
Angew Chem Int Ed
, vol.48
, pp. 9546-9548
-
-
Stecher, H.1
Tengg, M.2
Ueberbacher, B.J.3
Remler, P.4
Schwab, H.5
Griengl, H.6
Gruber-Khadjawi, M.7
-
27
-
-
77949831455
-
Enzyme-catalyzed transfer of a ketone group from an S-adenosylmethionine analogue: a tool for the functional analysis of methyltransferases
-
Lee B.W.K., Sun H.G., Zang T.Z., Kim B.J., Alfaro J.F., Zhou Z.S. Enzyme-catalyzed transfer of a ketone group from an S-adenosylmethionine analogue: a tool for the functional analysis of methyltransferases. J. Am. Chem. Soc. 2010, 132:3642-3643.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 3642-3643
-
-
Lee, B.W.K.1
Sun, H.G.2
Zang, T.Z.3
Kim, B.J.4
Alfaro, J.F.5
Zhou, Z.S.6
-
28
-
-
79953139279
-
Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling
-
Motorin Y., Burhenne J., Teimer R., Koynov K., Willnow S., Weinhold E., Helm M: Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling. Nucleic Acids Res 2011, 39:1943-1952.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 1943-1952
-
-
Motorin, Y.1
Burhenne, J.2
Teimer, R.3
Koynov, K.4
Willnow, S.5
Weinhold, E.6
Helm, M.7
-
29
-
-
84864957846
-
Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases
-
Tomkuviene M., Clouet-d'Orval B., Cerniauskas I., Weinhold E., Klimasauskas S: Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases. Nucleic Acids Res 2012, 40:6765-6773.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 6765-6773
-
-
Tomkuviene, M.1
Clouet-d'Orval, B.2
Cerniauskas, I.3
Weinhold, E.4
Klimasauskas, S.5
-
30
-
-
84866414211
-
Se-adenosyl-l-selenomethionine cofactor analogue as a reporter of protein methylation
-
Bothwell I.R., Islam K., Chen Y., Zheng W., Blum G., Deng H., Luo M: Se-adenosyl-l-selenomethionine cofactor analogue as a reporter of protein methylation. J Am Chem Soc 2012, 134:14905-14912.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 14905-14912
-
-
Bothwell, I.R.1
Islam, K.2
Chen, Y.3
Zheng, W.4
Blum, G.5
Deng, H.6
Luo, M.7
-
31
-
-
84859359078
-
Bioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-l-methionine
-
Islam K., Bothwell I., Chen Y., Sengelaub C., Wang R., Deng H., Luo M: Bioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-l-methionine. J Am Chem Soc 2012, 134:5909-5915.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 5909-5915
-
-
Islam, K.1
Bothwell, I.2
Chen, Y.3
Sengelaub, C.4
Wang, R.5
Deng, H.6
Luo, M.7
-
32
-
-
80055019988
-
Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies
-
Yao Y., Chen P., Diao J., Cheng G., Deng L., Anglin J.L., Prasad B.V.V., Song Y: Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies. J Am Chem Soc 2011, 133:16746-16749.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 16746-16749
-
-
Yao, Y.1
Chen, P.2
Diao, J.3
Cheng, G.4
Deng, L.5
Anglin, J.L.6
Prasad, B.V.V.7
Song, Y.8
-
33
-
-
41849105766
-
In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1
-
Osborne T., Roska R.L.W., Rajski S.R., Thompson PR: In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1. J Am Chem Soc 2008, 130:4574-4575.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 4574-4575
-
-
Osborne, T.1
Roska, R.L.W.2
Rajski, S.R.3
Thompson, PR.4
-
34
-
-
77954851029
-
Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling
-
Peters W., Willnow S., Duisken M., Kleine H., Macherey T., Duncan K.E., Litchfield D.W., Luscher B., Weinhold E: Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling. Angew Chem Int Ed 2010, 49:5170-5173.
-
(2010)
Angew Chem Int Ed
, vol.49
, pp. 5170-5173
-
-
Peters, W.1
Willnow, S.2
Duisken, M.3
Kleine, H.4
Macherey, T.5
Duncan, K.E.6
Litchfield, D.W.7
Luscher, B.8
Weinhold, E.9
-
35
-
-
80054019428
-
Formulating a fluorogenic assay to evaluate S-adenosyl-l-methionine analogues as protein methyltransferase cofactors
-
Wang R., Ibanez G., Islam K., Zheng W., Blum G., Sengelaub C., Luo M. Formulating a fluorogenic assay to evaluate S-adenosyl-l-methionine analogues as protein methyltransferase cofactors. Mol BioSyst 2011, 7:2970-2981.
-
(2011)
Mol BioSyst
, vol.7
, pp. 2970-2981
-
-
Wang, R.1
Ibanez, G.2
Islam, K.3
Zheng, W.4
Blum, G.5
Sengelaub, C.6
Luo, M.7
-
37
-
-
84887145999
-
Using azido analogue of S-adenosyl-l-methionine for bioorthogonal profiling of protein methylation (BPPM)
-
Blum G., Islam K., Luo M: Using azido analogue of S-adenosyl-l-methionine for bioorthogonal profiling of protein methylation (BPPM). Curr Protoc Chem Biol 2013, 5:45-66.
-
(2013)
Curr Protoc Chem Biol
, vol.5
, pp. 45-66
-
-
Blum, G.1
Islam, K.2
Luo, M.3
-
38
-
-
84887170134
-
Profiling protein methylation with cofactor analog containing terminal alkyne functionality
-
Blum G., Bothwell I., Islam K., Luo M: Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Curr Protoc Chem Biol 2013, 5:67-88.
-
(2013)
Curr Protoc Chem Biol
, vol.5
, pp. 67-88
-
-
Blum, G.1
Bothwell, I.2
Islam, K.3
Luo, M.4
-
39
-
-
78751622160
-
A chemical method for labeling lysine methyltransferase substrates
-
Binda O., Boyce M., Rush J.S., Palaniappan K.K., Bertozzi C.R., Gozani O: A chemical method for labeling lysine methyltransferase substrates. Chembiochem 2011, 12:330-334.
-
(2011)
Chembiochem
, vol.12
, pp. 330-334
-
-
Binda, O.1
Boyce, M.2
Rush, J.S.3
Palaniappan, K.K.4
Bertozzi, C.R.5
Gozani, O.6
-
40
-
-
84861453173
-
A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases
-
Willnow S., Martin M., Lüscher B., Weinhold E: A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases. Chembiochem 2012, 13:1167-1173.
-
(2012)
Chembiochem
, vol.13
, pp. 1167-1173
-
-
Willnow, S.1
Martin, M.2
Lüscher, B.3
Weinhold, E.4
-
41
-
-
79960367903
-
Chemogenetic analysis of human protein methyltransferases
-
Richon V.M., Johnston D., Sneeringer C.J., Jin L., Majer C.R., Elliston K., Jerva L.F., Scott M.P., Copeland RA: Chemogenetic analysis of human protein methyltransferases. Chem Biol Drug Des 2011, 78:199-210.
-
(2011)
Chem Biol Drug Des
, vol.78
, pp. 199-210
-
-
Richon, V.M.1
Johnston, D.2
Sneeringer, C.J.3
Jin, L.4
Majer, C.R.5
Elliston, K.6
Jerva, L.F.7
Scott, M.P.8
Copeland, RA.9
-
42
-
-
79957762180
-
Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-l-methionine analogues
-
Wang R., Zheng W., Yu H., Deng H., Luo M: Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-l-methionine analogues. J Am Chem Soc 2011, 133:7648-7651.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 7648-7651
-
-
Wang, R.1
Zheng, W.2
Yu, H.3
Deng, H.4
Luo, M.5
-
43
-
-
79960496067
-
Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling
-
Islam K., Zheng W., Yu H., Deng H., Luo M: Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling. ACS Chem Biol 2011, 6:679-684.
-
(2011)
ACS Chem Biol
, vol.6
, pp. 679-684
-
-
Islam, K.1
Zheng, W.2
Yu, H.3
Deng, H.4
Luo, M.5
-
44
-
-
84872784135
-
Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells
-
Wang R., Islam K., Liu Y., Zheng W., Tang H., Lailler N., Blum G., Deng H., Luo M: Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells. J Am Chem Soc 2013, 135:1048-1056.
-
(2013)
J Am Chem Soc
, vol.135
, pp. 1048-1056
-
-
Wang, R.1
Islam, K.2
Liu, Y.3
Zheng, W.4
Tang, H.5
Lailler, N.6
Blum, G.7
Deng, H.8
Luo, M.9
-
45
-
-
60149109785
-
Structure-function relationships in methionine adenosyltransferases
-
Markham G.D., Pajares MA: Structure-function relationships in methionine adenosyltransferases. Cell Mol Life Sci 2009, 66:636-648.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 636-648
-
-
Markham, G.D.1
Pajares, MA.2
-
46
-
-
80455144759
-
Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity
-
Li J., Wei H., Zhou MM: Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity. J Med Chem 2011, 54:7734-7738.
-
(2011)
J Med Chem
, vol.54
, pp. 7734-7738
-
-
Li, J.1
Wei, H.2
Zhou, MM.3
|