Piroxicam Treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria

Inflammatory Bowel Diseases

Volumn 11, Issue 12, 2005, Pages 1060-1069

  Hale, Laura P ^a   Gottfried, Marcia R ^a   Swidsinski, Alexander ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Fluorescence in situ hybridization; Inflammatory bowel disease; Intestinal flora; Nonsteroidal anti inflammatory drugs

Indexed keywords

INTERLEUKIN 10; PIROXICAM; RIBOSOME RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ADHERENCE; CELL LINE; CELL PROLIFERATION; COLON MUCOSA; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG EXPOSURE; EPITHELIUM CELL; FEMALE; FLUORESCENCE ANALYSIS; GENE DELETION; GENETIC SUSCEPTIBILITY; HYPOTHESIS; IN SITU HYBRIDIZATION; INTESTINE FLORA; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CELLS, CULTURED; COLITIS; COLON; COLORIMETRY; EPITHELIUM; FEMALE; IN SITU HYBRIDIZATION, FLUORESCENCE; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; PIROXICAM;

EID: 27944447984     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/01.MIB.0000187582.90423.bc     Document Type: Article

References (36)

1. Boismenu R, Chen Y. Insights from mouse models of colitis. J Leukoc Biol. 2000;67:267-278.
2. Wirtz S, Neurath MF. Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease. Int J Colorectal Dis. 2000;15:144-160.
3. Hibi T, Ogata H, Sakuraba A. Animal models of inflammatory bowel disease. J Gastroenterol. 2002;37:409-417.
4. Strober WS, Fuss IJ, Blumberg RS. Immunology of mucosal models of inflammation. Annu Rev Immunol. 2002;20:495-549.
5. + Th1-like responses. J Clin Invest. 1996;98:1010-1020.
6. Davidson NJ, Hudak SA, Lesley RE, et al. IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J Immunol. 1998;161:3143-3149.
7. Wittig BM, Johansson B, Zoller M, et al. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J Exp Med. 2000;191:2053-2064.
8. Berg DJ, Zhang J, Weinstock JV, et al. Rapid development of colitis in NSAID-treated IL-10-deficient mice. Gastroenterol. 2002;123:1527-1542.
9. Matsuo K, Ota H, Akamatsu T, et al. Histochemistry of the surface mucous gel layer of the human colon. Gut. 1997;40:782-789.
10. Burich A, Hershberg R, Waggie K, et al. Helicobacter-induced inflammatory bowel disease in IL-10 and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2001;281:G764-G778.
11. Amann R, Krumholz L, Stahl DA. Fluorescent-oligonucleotide probing of whole cells for determinative, phylogenetic, and environmental studies in microbiology. J Bacteriol. 1990;172:762-770.
12. Harmsen HJ, Raangs GC, He T, et al. Extensive set of 16S rRNA-based probes for detection of bacteria in human feces. Appl Environ Microbiol. 2002;68:2982-2990.
13. Franks AH, Harmsen HJ, Raangs GC, et al. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol. 1998;64:3336-3345.
14. Maiden L, Thjodleifsson B, Theodors A, et al. A quantitative analysis of NSAID-induced small bowel pathology by capsule endoscopy. Gastroenterol. 2005;128:1172-1178.
15. Ito K, Takaishi H, Jin Y, et al. Staphylococcal enterotoxin B stimulates expansion of autoreactive T cells that induce apoptosis in intestinal epithelial cells: regulation of autoreactive responses by IL-10. J Immunol. 2000;164:2994-3001.
16. Denning TL, Campbell NA, Song F, et al. Expression of IL-10 receptors on epithelial cells from the murine small and large intestine. Int Immunol. 2000;12:133-139.
17. Stassi G, Di Liberto D, Todaro M, et al. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Nat Immunol. 2000;1:483-488.
18. Stassi G, De Maria R. Autoimmune thyroid disease: new models of cell death in autoimmunity. Nat Rev Immunol. 2002;2:195-204.
19. Stassi G, Todaro M, Zerilli M, et al. Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10. Cancer Res. 2003;63:6784-6790.
20. Rath HC, Herfarth HH, Ikeda JS, et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 1996;98:945-953.
21. Rath HC, Wilson KH, Sartor RB. Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. Infect Immun. 1999;67:2969-2974.
22. Duchmann R, May E, Heike M, et al. T cell specificity and cross reactivity towards enterobacteria, bacteroides, Bifidobacterium, and antigens from the resident intestinal flora in humans. Gut. 1999;44:812-818.
23. Wei B, Dalwadi H, Gordon LK, et al. Molecular cloning of a Bacteroides caccae TonB-linked outer membrane protein identified by an inflammatory bowel disease marker antibody. Infect Immun. 2001;69:6044-6054.
24. Saitoh S, Noda S, Aiba Y, et al. Bacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease. Clin Diagn Lab Immunol. 2002;9:54-59.
25. Swidsinski A, Ladhoff A, Pernthaler A, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology. 2002;122:44-54.
26. Orii S, Yamaguchi T, Anzai H, et al. Chemoprevention for colorectal tumorigenesis associated with chronic colitis in mice via apoptosis. J Exp Clin Cancer Res. 2003;22:41-46.
27. Brock TG, McNish RW, Peters-Golden M. Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J Biol Chem. 1999;274:11660-11666.
28. Jabbour HN, Kelly RW, Boddy SC. Autocrine/paracrine regulation of apoptosis in epithelial cells by prostaglandin E2. Prostaglandins Leukot Essent Fatty Acids. 2002;67:357-363.
29. Subbaramaiah K, Altorki N, Chung WJ, et al. Inhibition of cyclo-oxygenase-2 gene expression by p53. J Biol Chem. 1999;274:10911-10915.
30. Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995;83:493-501.
31. Gleeson MH, Davis JM. Non-steroidal anti-inflammatory drugs, aspirin and newly diagnosed colitis: a case-control study. Aliment Pharmacol Ther. 2003;17:817-825.
32. Reinisch W, Miehsler W, Dejaco C, et al. An open label trial of the selective cyclo-oxygenase-2 inhibitor, rofecoxib, in inflammatory bowel disease-associated peripheral arthritis and arthralgia. Aliment Pharmacol Ther. 2003;17:1371-1380.
33. Smale S, Sigthorsson G, Foster R, et al. NSAIDs and relapse of IBD. Gastroenterology. 2002;122:A23.
34. Matuk R, Crawford J, Abreu MT, et al. The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004;10:352-356.
35. Eaden J. Review article: the data supporting a role for aminosalicylates in the chemoprevention of colorectal cancer in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2003;18:15-21.
36. Reinacher-Schick A, Schoeneck A, Graeven U, et al. Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells. Carcinogenesis. 2003;24:443-451.