Toxicity Studies on Secretio Bufonis: A Traditional Supplement in Asia

JAMS Journal of Acupuncture and Meridian Studies

Volumn 2, Issue 2, 2009, Pages 159-164

  Yoo, Won Seung ^a   Kim, Jungsun ^a   Lee, Yeon Weol ^a   Yoon, Dae Hwan ^b   Cho, Chong Kwan ^a   Yoo, Hwa Seung ^a  

^a Daejeon University   (South Korea)

^b Dongshin University   (South Korea)

Author keywords

amphibian venoms; in vivo; no observed adverse effect level; Secretio Bufonis; toxicity

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CREATININE; NITROGEN; SECRETIO BUFONIS; UNCLASSIFIED DRUG; UREA; VENOM; BIOLOGICAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BRAIN WEIGHT; CARDIOTOXICITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; HEART WEIGHT; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; TOXICITY TESTING; TRADITIONAL MEDICINE; UREA NITROGEN BLOOD LEVEL; ANATOMY AND HISTOLOGY; ANIMAL; ASIA; BLOOD; BUFONIDAE; CHINESE MEDICINE; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; KIDNEY; LIVER; ORGAN SIZE; URINE;

ANIMALS; ASIA; BIOLOGICAL PRODUCTS; BUFONIDAE; KIDNEY; LIVER; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, INBRED ICR; ORGAN SIZE;

EID: 67651085417     PISSN: 20052901     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2005-2901(09)60049-2     Document Type: Article

References (11)

1. Chen K.K., and Kovarikove A. Pharmacology and toxicology of toad venom. J Pharm Sci 56 (1967) 1535-1541
2. Daly J.W., Noimai N., Kongkathip B., Kongkgthip N., Wilham J.M., and Garraffo H.M. Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand. Toxicon 44 (2004) 805-815
3. Wu W., Chai X., Li G., Zhang H., Long S., Xue X., et al. Preliminary results of combination therapy with Chinese herbs and Vinorelbine in elderly advanced non-small cell lung cancer. Journal of US-China Medical Science 3 (2006) 72-77
4. Zhao Y., Luo X., Ming Y., Chen L., and Li Y. Rapid separation and determination of resibufogenin and cinobufagin in toad venom and Liushen tablet by β-cyclodextrin modified micellar electrokinetic chromatography. J Pharm Biomed Anal 41 (2006) 124-128
5. Gowda R.M., Cohen R.A., and Khan I.A. Toad venom poisoning: resemblance to digoxin toxicity and therapeutic implications. Heart 89 (2003) e14
6. Ko R.J., Greenwald M.S., Loscutoff S.M., AU A.M., Appel B.R., Kreutzer R., et al. Lethal ingestion of Chinese herbal tea containing Ch'an Su. West J Med 164 (1996) 71-75
7. Das M., Auddy B., and Gomes A. Pharmacological study of the toad skin extract on experimental animals. Indian Journal of Pharmacology 28 (1996) 72-76
8. He X., Tang J., Qiao A., Wang G., Jiang M., Liu R.H., et al. Cytotoxic biotransformed products from cinobufagin by Mucor spinosus and Aspergillus Niger. Steroids 71 (2006) 392-402
9. Tortora G.J., Graqbowski S.R., and Roesch B. Blood test. Principles of anatomy and physiology. 9th ed (2000), John Wiley & Son, New York 943
10. Cui Y.A., Zuo X.D., and Qin S.K. Clinical trial of Huachansu injection for anti-cancer efficacy. Jiangsu Journal of Clinical Medicine 6 (2002) 505-508
11. Wu W.Y., Chen C.Y., and Zhang H.B. Huachansu injection in treating 48 patients with stage IIIb/IV non-small cell lung cancer and SCLC. Chinese Journal of Current Practical Medicine 3 (2004) 38-40