Simultaneous determination of three bufadienolides in rat plasma after intravenous administration of bufadienolides extract by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry

Analytica Chimica Acta

Volumn 610, Issue 2, 2008, Pages 224-231

  Zhang, Yu ^a   Tang, Xing ^a   Liu, Xiaoliang ^a   Li, Fang ^a   Lin, Xia ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Bufadienolides; Pharmacokinetics; Rat plasma; Ultra performance liquid chromatography tandem mass spectrometry

Indexed keywords

ACETONITRILE; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

BUFADIENOLIDES; RAT PLASMA;

PLASMAS;

ACETONITRILE; BUFADIENOLIDE; BUFALIN; BUFOGENIN; CINOBUFAGIN; DIPHENHYDRAMINE; FORMIC ACID; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALIBRATION; CHINESE MEDICINE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; FLOW RATE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PHASE SEPARATION; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY;

ANIMALS; BUFANOLIDES; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INFUSIONS, INTRAVENOUS; MALE; RATS; RATS, WISTAR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 39149134583     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aca.2008.01.029     Document Type: Article

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