Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components

Chemico-Biological Interactions

Volumn 195, Issue 2, 2012, Pages 105-113

  Jiang, Bo ^a   Cai, Fei ^a   Gao, Shouhong ^a   Meng, Liyuan ^b   Liang, Fengying ^a   Dai, Xiao ^a   Xu, Wen ^a   Chen, Wansheng ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bufalin; Cinobufagin; CYP3A; Induction; Shexiang Baoxin Pill

Indexed keywords

BORNEOL; BUFALIN; BUFOGENIN; CHINESE DRUG; CINNAMALDEHYDE; CINOBUFAGIN; CYTOCHROME P450 3A; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; DEXAMETHASONE; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; KETOCONAZOLE; MESSENGER RNA; RIFAMPICIN; SHEXIANG BAOXIN PILL; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVITY; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TRADITIONAL MEDICINE;

ANIMALS; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME INDUCTION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HEPATOBLASTOMA; HUMANS; MALE; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION;

ANGINA; RATTUS;

EID: 84455174007     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.12.001     Document Type: Article

References (47)

1. S. Rendic Summary of information on human CYP enzymes: human P450 metabolism data Drug Metab. Rev. 34 2002 83 448 (Pubitemid 34311090)
2. S.A. Wrighton, E.G. Schuetz, K.E. Thummel, D.D. Shen, K.R. Korzekwa, and P.B. Watkins The human CYP3A subfamily: practical considerations Drug Metab. Rev. 32 2000 339 361 (Pubitemid 32001911)
3. D. Pekthong, N. Blanchard, C. Abadie, A. Bonet, B. Heyd, G. Mantion, A. Berthelot, L. Richert, and H. Martin Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures Chem. Biol. Interact. 179 2009 247 255
4. M. Zhu, K. Chan, L. Ng, Q. Chang, S. Chang, and R. Li Possible influences of ginseng on the pharmacokinetics and pharmacodynamics of warfarin in rats J. Pharm. Pharmacol. 51 1999 175 180 (Pubitemid 29131310)
5. Y. Deng, H.C. Bi, L.Z. Zhao, X.D. Wang, J. Chen, Z.M. Ou, L. Ding, L.J. Xu, S. Guan, X. Chen, S.F. Zhou, and M. Huang Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes Drug Metab. Lett. 2 2008 60 66 (Pubitemid 351411264)
6. L. Wang, F. Li, J. Lu, G. Li, D. Li, X.B. Zhong, G.L. Guo, and X. Ma The Chinese herbal medicine Sophora flavescens activates pregnane X receptor Drug Metab. Dispos. 38 2010 2226 2231
7. H. Ye, J. Du, D. Shen, S. Shi, T. Huang, Z. Hong, Y. Mao, F. Li, and L. Zhou Effect of shexiang baoxin pill on the function of vascular endothelium in patients with diabetes mellitus type 2 complicated with angina pectoris Chin. J. Integr. Tradit. West. Med. 24 2004 1077 1079
8. S. Wang, R. Dai, and C. Jin Clinical observation on artificial shexiang baoxin pill in treating 112 patients of coronary heart disease with angina pectoris Chin. J. Integr. Tradit. West. Med. 18 1998 204 207
9. Chinese Pharmacopoeia Commission, Pharmacopoeia of the People's Republic of China, Shexiang Baoxin Pills, People's Medical Publishing House, Beijing, 2005, pp. 624-625.
10. Y. Hong, H. Wu, and P. Zhao Effects of shexiang baoxin pill on carotid atheromatous plaque Chin. J. Integr. Tradit. West. Med. 26 2006 780 783
11. L.J. Wang, X.P. Luo, and Y. Wang Evaluation on tolerability and safety of long-term administration with shexiang baoxin pill in patients with coronary heart disease of stable angina pectoris Chin. J. Integr. Tradit. West. Med. 28 2008 399 401
12. G.J. Wu Joint betaloc treatment shexiangbaoxin pill clinical effects of 120 angina pectoris Chin. J. Med. Guide. 11 2009 972 973
13. E. Tanaka, N. Kurata, M. Kohno, T. Yoshida, and Y. Kuroiwa Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats Biochem. Pharmacol. 36 1987 4263 4267 (Pubitemid 18016179)
14. E. Tanaka, Y. Funae, S. Imaoka, and S. Misawa Characterization of liver microsomal cytochrome P450 from rats treated with muscone (3- methylcyclopentadecanone) Biochem. Pharmacol. 41 1991 472 473
15. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63 (Pubitemid 14203433)
16. S. Wilkening, F. Stahl, and A. Bader Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties Drug Metab. Dispos. 31 2003 1035 1042 (Pubitemid 36975674)
17. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
18. X. Decleves, S. Bihorel, M. Debray, S. Yousif, G. Camenisch, and J.M. Scherrmann ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells Pharmacol. Res. 57 2008 214 222
19. S.J. Baldwin, J.L. Bramhall, C.A. Ashby, L. Yue, P.R. Murdock, S.R. Hood, A.D. Ayrton, and S.E. Clarke Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan) Drug Metab. Dispos. 34 2006 1063 1069 (Pubitemid 43763766)
20. W. Xu, H. Luo, Y. Zhang, L. Shan, H. Li, M. Yang, R. Liu, and W. Zhang Simultaneous determination of five main active bufadienolides of Chan Su in rat plasma by liquid chromatography tandem mass spectrometry J. Chromatogr. B 859 2007 157 163 (Pubitemid 350046447)
21. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408 (Pubitemid 34164012)
22. F.J. Gonzalez, D.W. Nebert, J.P. Hardwick, and C.B. Kasper Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family J. Biol. Chem. 260 1985 7435 7441 (Pubitemid 15063019)
23. K. Kraft Complementary/alternative medicine in the context of prevention of disease and maintenance of health Prev. Med. 49 2009 88 92
24. N.C. Brazier, and M.A. Levine Drug-herb interaction among commonly used conventional medicines: a compendium for health care professionals Am. J. Ther. 10 2003 163 169
25. J.P. Kelly, D.W. Kaufman, K. Kelley, L. Rosenberg, T.E. Anderson, and A.A. Mitchell Recent trends in use of herbal and other natural products Arch. Intern. Med. 165 2005 281 286 (Pubitemid 40216279)
26. H. Kim, K.B. Kim, H.Y. Ku, S.J. Park, H. Choi, J.K. Moon, B.S. Park, J.H. Kim, S.S. Yea, C.H. Lee, H.S. Lee, J.G. Shin, and K.H. Liu Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China Drug Metab. Dispos. 36 2008 1010 1015 (Pubitemid 351717457)
27. N.J. Hewitt, M.J. Lechon, J.B. Houston, D. Hallifax, H.S. Brown, P. Maurel, J.G. Kenna, L. Gustavsson, C. Lohmann, and C. Skonberg Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies Drug Metab. Rev. 39 2007 159 234
28. E.F. Brandon, C.D. Raap, I. Meijerman, J.H. Beijnen, and J.H. Schellens An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons Toxicol. Appl. Pharmacol. 189 2003 233 246 (Pubitemid 36677534)
29. O. Pelkonen, M. Turpeinen, J. Hakkola, P. Honkakoski, J. Hukkanen, and H. Raunio Inhibition and induction of human cytochrome P450 enzymes: current status Arch. Toxicol. 82 2008 667 715
30. W.M. Westerink, and W.G. Schoonen Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells Toxicol. In Vitro 21 2007 1581 1591 (Pubitemid 350103536)
31. G. Elizondo, and I.M. Medina-Diaz Induction of CYP3A4 by 1alpha, 25-dyhydroxyvitamin D3 in HepG2 cells Life Sci. 73 2003 141 149 (Pubitemid 36555934)
32. T. Usui, Y. Saitoh, and F. Komada Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor Biol. Pharm. Bull. 26 2003 510 517 (Pubitemid 39663598)
33. I.M. Medina-Diaz, and G. Elizondo Transcriptional induction of CYP3A4 by o, p′-DDT in HepG2 cells Toxicol. Lett. 157 2005 41 47 (Pubitemid 40410611)
34. M. Sinz, S. Kim, Z. Zhu, T. Chen, M. Anthony, K. Dickinson, and A.D. Rodrigues Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions Curr. Drug Metab. 7 2006 375 388
35. L. Li, J.D. Stanton, A.H. Tolson, Y. Luo, and H. Wang Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways Pharm. Res. 26 2009 872 882
36. N.J. Hewitt, and P. Hewitt Phase I and II enzyme characterization of two sources of HepG2 cell lines Xenobiotica 34 2004 243 256 (Pubitemid 38478893)
37. T. Matsubara, H.J. Kim, M. Miyata, M. Shimada, K. Nagata, and Y. Yamazoe Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat J. Pharmacol. Exp. Ther. 309 2004 1282 1290 (Pubitemid 38669720)
38. D.F.V. Lewis Cytochrome P450: Structure, Function and Mechanism 1996 Taylor & Francis London pp. 123
39. Y.J. Moon, A.K. Lee, H.C. Chung, E.J. Kim, S.H. Kim, D.C. Lee, I. Lee, S.G. Kim, and M.G. Lee Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats Drug Metab. Dispos. 31 2003 776 784 (Pubitemid 36617668)
40. Food and Drug Administration/Center for Drug Evaluation and Research (FDA/CDER), Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers, Rockville, MD, 2005, pp. 6-9.
41. S.K. Yan, W.D. Zhang, R.H. Liu, and Y.C. Zhan Chemical fingerprinting of Shexiang Baoxin Pill and simultaneous determination of its major constituents by HPLC with evaporative light scattering detection and electrospray mass spectrometric detection Chem. Pharm. Bull. (Tokyo) 54 2006 1058 1062
42. P. Jiang, R. Liu, S. Dou, L. Liu, W. Zhang, Z. Chen, R. Xu, and J. Ding Analysis of the constituents in rat plasma after oral administration of Shexiang Baoxin pill by HPLC-ESI-MS/MS Biomed. Chromatogr. 23 2009 1333 1343
43. X. Xia, H. Jin, S. Yan, and W. Zhang Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection J. Pharm. Biomed. 53 2010 646 654
44. R. Peng, X.Y. Zhu, and C.S. Yang Induction of rat liver microsomal cytochrome P-450 by muscone (3-methylcyclopentadecanone) Biochem. Pharmacol. 35 1986 1391 1394 (Pubitemid 16037051)
45. H. Li, W. Xu, X. Zhang, W. Zhang, and L. Hu Bufalin inhibits CYP3A4 activity in vitro and in vivo Acta Pharmacol. Sin. 30 2009 646 652
46. R.W. Nims, R.A. Prough, C.R. Jones, D.L. Stockus, K.H. Dragnev, P.E. Thomas, and R.A. Lubet In vivo induction and in vitro inhibition of hepatic cytochrome P450 activity by the benzodiazepine anticonvulsants clonazepam and diazepam Drug Metab. Dispos. 25 1997 750 756 (Pubitemid 27259976)
47. J. Sahi, C.B. Black, G.A. Hamilton, X. Zheng, S. Jolley, K.A. Rose, D. Gilbert, E.L. LeCluyse, and M.W. Sinz Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition Drug Metab. Dispos. 31 2003 439 446 (Pubitemid 36378521)