MTORC2 regulates renal tubule sodium uptake by promoting ENaC activity

Journal of Clinical Investigation

Volumn 125, Issue 1, 2015, Pages 117-128

  Gleason, Catherine E ^a   Frindt, Gustavo ^b   Cheng, Chih Jen ^c,e   Ng, Michael ^a   Kidwai, Atif ^a,f   Rashmi, Priyanka ^a   Lang, Florian ^d   Baum, Michel ^c   Palmer, Lawrence G ^b   Pearce, David ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^f TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; AMILORIDE; AZD 8055; EPITHELIAL SODIUM CHANNEL; HYDROCHLOROTHIAZIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; RAPAMYCIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; ESCRT PROTEIN; IMMEDIATE EARLY PROTEIN; INDOLE DERIVATIVE; MTOR PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; NEDD4 UBIQUITIN PROTEIN LIGASES; PROTEIN SERINE THREONINE KINASE; PURINE DERIVATIVE; SERUM-GLUCOCORTICOID REGULATED KINASE; SODIUM; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTROLYTE URINE LEVEL; FEMALE; HOMEOSTASIS; IN VITRO STUDY; KIDNEY COLLECTING TUBULE; KIDNEY PERFUSION; MALE; MOUSE; NATRIURESIS; NONHUMAN; PATCH CLAMP TECHNIQUE; PHARMACOLOGICAL BLOCKING; POTASSIUM EXCRETION; POTASSIUM TRANSPORT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SODIUM ABSORPTION; SODIUM BALANCE; SODIUM EXCRETION; SODIUM RETENTION; SODIUM TRANSPORT; URINE VOLUME; 129 MOUSE; ANIMAL; C57BL MOUSE; KIDNEY DISTAL TUBULE; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

AMILORIDE; ANIMALS; BIOLOGICAL TRANSPORT; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EPITHELIAL SODIUM CHANNELS; FEMALE; IMMEDIATE-EARLY PROTEINS; INDOLES; KIDNEY TUBULES, DISTAL; MALE; MEMBRANE POTENTIALS; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PURINES; RATS, SPRAGUE-DAWLEY; SIROLIMUS; SODIUM; TOR SERINE-THREONINE KINASES; UBIQUITIN-PROTEIN LIGASES;

EID: 84920380185     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI73935     Document Type: Article

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