Significant reduction of ATP production in PHA-activated CD4+ Cells in 1-Day-Old Blood from Transplant Patients

Transplantation

Volumn 94, Issue 12, 2012, Pages 1243-1249

  Suviolahti, Elina ^a   Petrosyan, Anna ^a   Mirocha, James ^a   Ge, Shili ^a   Karasyov, Artur ^a   Thomas, David ^a   Galera, Odette ^a   Lim, Washington ^a   Jimenez, Anne Maria ^a   Czer, Lawrence S C ^a   Chaux, George ^a   De Leon, Jeffrey ^a   Pao, Andy ^a   Jordan, Stanley C ^a   Toyoda, Mieko ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

ATP levels; Blood storage; Monitoring of transplant patients; T cell immune function assay

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALEMTUZUMAB; AZATHIOPRINE; BASILIXIMAB; CD4 ANTIGEN; CYCLOSPORIN A; DACLIZUMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHYTOHEMAGGLUTININ; PREDNISONE; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; BLOOD STORAGE; BLOOD STORAGE TIME; CARDIAC GRAFT REJECTION; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; GRAFT RECIPIENT; HUMAN; KIDNEY GRAFT REJECTION; LUNG GRAFT REJECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TRANSPLANTATION;

ADENOSINE TRIPHOSPHATE; ADULT; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; BLOOD SPECIMEN COLLECTION; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; IMMUNOLOGIC TECHNIQUES; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE COUNT; MALE; ORGAN TRANSPLANTATION; PHYTOHEMAGGLUTININS; REPRODUCIBILITY OF RESULTS; TIME FACTORS; YOUNG ADULT;

EID: 84872084836     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318270f322     Document Type: Article

References (35)

1. Sawitzki B, Schlickeiser S, Reinke P, et al. Monitoring tolerance and rejection in organ transplant recipients. Biomarkers 2011; 16(Suppl 1): S42.
2. Patel J, Kobashigawa JA. Minimization of immunosuppression: transplant immunology. Transpl Immunol 2008; 20: 48.
3. Kowalski RJ, Zeevi A, Mannon RB, et al. Immunodiagnostics: evaluation of functional T-cell immunocompetence in whole blood independent of circulating cell numbers. J Immunotoxicol 2007; 4: 225.
4. Hartono C, Muthukumar T, Suthanthiran M. Noninvasive diagnosis of acute rejection of renal allografts. Curr Opin Organ Transplant 2010; 15: 35.
5. Kowalski R, Post D, Schneider MC, et al. Immune cell function testing: an adjunct to therapeutic drug monitoring in transplant patient management. Clin Transplant 2003; 17: 77.
6. Hooper E, Hawkins DM, Kowalski RJ, et al. Establishing pediatric immune response zones using the Cylex ImmuKnow assay. Clin Transplant 2005; 19: 834.
7. Batal I, Zeevi A, Heider A, et al. Measurements of global cell-mediated immunity in renal transplant recipients with BK virus reactivation. Am J Clin Pathol 2008; 129: 587.
8. Gautam A, Fischer SA, Yango AF, et al. Cell mediated immunity (CMI) and post transplant viral infectionsVrole of a functional immune assay to titrate immunosuppression. Int Immunopharmacol 2006; 6: 2023.
9. Helantera I, Koskinen P. Association of immune cell function assay with protocol biopsy findings and viral infections in well matched kidney transplant recipients. Clin Nephrol 2010; 74: 123.
10. Israeli M, Yussim A, Mor E, et al. Preceeding the rejection: in search for a comprehensive post-transplant immune monitoring platform. Transpl Immunol 2007; 18: 7.
11. Millan O, Sanchez-Fueyo A, Rimola A, et al. Is the intracellular ATP concentration of CD4+ T-Cells a predictive biomarker of immune status in stable transplant recipients? Transplantation 2009; 88(Suppl 3): S78.
12. Sampson VB, Dunn SP, Rymeski B, et al. Failure of immunosuppressive drug levels to predict T-cell reactivity in pediatric transplant patients. J Pediatr Surg 2008; 43: 1134.
13. Sanchez-Velasco P, Rodrigo E, Valero R, et al. Intracellular ATP concentrations of CD4 cells in kidney transplant patients with and without infection. Clin Transplant 2008; 22: 55.
14. Serban G, Whittaker V, Fan J, et al. Significance of immune cell function monitoring in renal transplantation after Thymoglobulin induction therapy. Hum Immunol 2009; 70: 882.
15. Israeli M, Ben-Gal T, Yaari V, et al. Individualized immune monitoring of cardiac transplant recipients by noninvasive longitudinal cellular immunity tests. Transplantation 2010; 89: 968.
16. Kobashigawa JA, Kiyosaki KK, Patel JK, et al. Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes. J Heart Lung Transplant 2010; 29: 504.
17. Bhorade SM, Janata K, Vigneswaran WT, et al. Cylex ImmuKnow assay levels are lower in lung transplant recipients with infection. J Heart Lung Transplant 2008; 27: 990.
18. Husain S, Raza K, Pilewski JM, et al. Experience with immune monitoring in lung transplant recipients: correlation of low immune function with infection. Transplantation 2009; 87: 1852.
19. Cabrera R, Ararat M, Soldevila-Pico C, et al. Using an immune functional assay to differentiate acute cellular rejection from recurrent hepatitis C in liver transplant patients. Liver Transpl 2009; 15: 216.
20. Hashimoto K, Miller C, Hirose K, et al. Measurement of CD4+ T-cell function in predicting allograft rejection and recurrent hepatitis C after liver transplantation. Clin Transplant 2010; 24: 701.
21. Lee TC, Goss JA, Rooney CM, et al. Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection. Clin Transplant 2006; 20: 689.
22. Mendler M, Kwok H, Franco E, et al. Monitoring peripheral blood CD4+ adenosine triphosphate activity in a liver transplant cohort: insight into the interplay between hepatitis C virus infection and cellular immunity. Liver Transpl 2008; 14: 1313.
23. Mizuno S, Hamada T, Nakatani K, et al. Monitoring peripheral blood CD4+ adenosine triphosphate activity after living donor liver transplantation: impact of combination assays of immune function and CYP3A5 genotype. J Hepatobiliary Pancreat Sci 2011; 18: 226.
24. Xue F, Zhang J, Han L, et al. Immune cell functional assay in monitoring of adult liver transplantation recipients with infection. Transplantation 2010; 89: 620.
25. Thai NL, Blisard D, Tom K, et al. Pancreas transplantation under alemtuzumab (Campath-1H) and tacrolimus: Correlation between low T-cell responses and infection. Transplantation 2006; 82: 1649.
26. Ben-Youssef R, Baron PW, Sahney S, et al. The impact of intercurrent EBV infection on ATP levels in CD4+ T cells of pediatric kidney transplant recipients. Pediatr Transplant 2009; 13: 851.
27. Gupta S, Mitchell JD, Markham DW, et al. Utility of the Cylex assay in cardiac transplant recipients. J Heart Lung Transplant 2008; 27: 817.
28. Rossano JW, Denfield SW, Kim JJ, et al. Assessment of the Cylex ImmuKnow cell function assay in pediatric heart transplant patients. J Heart Lung Transplant 2009; 28: 26.
29. Huskey J, Gralla J, Wiseman AC. Single time point immune function assay (ImmuKnow) testing does not aid in the prediction of future opportunistic infections or acute rejection. Clin J Am Soc Nephrol 2011; 6: 423.
30. Bennett WM, Meyer L, Ridenour J, et al. Surveillance and modification of immunosuppression minimizes BK virus nephropathy. Am J Nephrol 2010; 32: 10.
31. Dong JY, Yin H, Li RD, et al. The relationship between adenosine triphosphate within CD4(+) T lymphocytes and acute rejection after liver transplantation. Clin Transplant 2011; 25: E292.
32. Kowalski RJ, Post DR, Mannon RB, et al. Assessing relative risks of infection and rejection: a meta-analysis using an immune function assay. Transplantation 2006; 82: 663.
33. Kabengera S, Hom D, Jackson B. Effect of specimen storage on absolute CD4 counts. Clin Diagn Lab Immunol 1994; 1: 232.
34. Belloni P, Meschini R, Palitti F. Effects of storage conditions of human whole blood on the viability of lymphocytes. Int J Radiat Biol 2008; 84: 613.
35. Ge S, Pao A, Vo A, et al. Immunologic parameters and viral infections in patients desensitized with intravenous immunoglobulin and rituximab. Transpl Immunol 2011; 24: 142.