Neurodevelopmental origins of depressive disorders (DOI:10.1016/j.coph.2006.11.006);Neurodevelopmental origins of depressive disorders

Current Opinion in Pharmacology

Volumn 7, Issue 1, 2007, Pages 8-17

  Ansorge, Mark S ^a   Hen, René ^a   Gingrich, Jay A ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DNA; GLUCOCORTICOID; MONOAMINE; NORADRENALIN; SCATTER FACTOR RECEPTOR; SEROTONIN; SEROTONIN 1A RECEPTOR; STEROID RECEPTOR; TRYPTOPHAN HYDROXYLASE;

ANXIETY DISORDER; BRAIN CELL; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CELL MATURATION; DEPRESSION; DIAGNOSTIC PROCEDURE; EMOTION; ENVIRONMENTAL FACTOR; EPIGENETICS; HEREDITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MATERNAL DEPRIVATION; NEUROPSYCHIATRY; NEUROTROPISM; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN FUNCTION; PSYCHOTRAUMA; REVIEW; RISK ASSESSMENT; SIGNAL TRANSDUCTION; THALAMUS MIDLINE NUCLEUS;

EID: 33846902654     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2007.02.002     Document Type: Erratum

References (73)

1. Mann J.J., and Currier D. Effects of genes and stress on the neurobiology of depression. Int Rev Neurobiol 73 (2006) 153-189
2. Leonardo E.D., and Hen R. Genetics of affective and anxiety disorders. Annu Rev Psychol 57 (2006) 117-137
3. Nutt D.J. The neuropharmacology of serotonin and noradrenaline in depression. Int Clin Psychopharmacol 17 Suppl 1 (2002) S1-S12
4. Leonard B.E. Evidence for a biochemical lesion in depression. J Clin Psychiatry 61 Suppl 6 (2000) 12-17
5. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., and Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
6. Collier D.A., Stober G., Li T., Heils A., Catalano M., Di Bella D., Arranz M.J., Murray R.M., Vallada H.P., Bengel D., et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1 (1996) 453-460
7. Gutierrez B., Pintor L., Gasto C., Rosa A., Bertranpetit J., Vieta E., and Fananas L. Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Hum Genet 103 (1998) 319-322
8. Levinson D.F. The genetics of depression: a review. Biol Psychiatry 60 (2006) 84-92
9. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
10. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., and Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry 62 (2005) 529-535
11. Holmes A., Lit Q., Murphy D.L., Gold E., and Crawley J.N. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav 2 (2003) 365-380
12. Lira A., Zhou M., Castanon N., Ansorge M.S., Gordon J.A., Francis J.H., Bradley-Moore M., Lira J., Underwood M.D., Arango V., et al. Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry 54 (2003) 960-971
13. Haydon P.G., McCobb D.P., and Kater S.B. The regulation of neurite outgrowth, growth cone motility, and electrical synaptogenesis by serotonin. J Neurobiol 18 (1987) 197-215
14. Haydon P.G., McCobb D.P., and Kater S.B. Serotonin selectively inhibits growth cone motility and synaptogenesis of specific identified neurons. Science 226 (1984) 561-564
15. Gaspar P., Cases O., and Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4 (2003) 1002-1012
16. Lauder J.M. Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Ann N Y Acad Sci 600 (1990) 297-313 discussion 314
17. Ansorge M.S., Zhou M., Lira A., Hen R., and Gingrich J.A. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306 (2004) 879-881
18. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., Egan M.F., and Weinberger D.R. Serotonin transporter genetic variation and the response of the human amygdala. Science 297 (2002) 400-403
19. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., Egan M.F., Mattay V.S., Hariri A.R., and Weinberger D.R. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8 (2005) 828-834. A human study combining genetics, neuroimaging and psychological assessment to investigate the role of the 5HTTLPR polymorphism in modulating brain function and emotional behavior. This study demonstrates that the 5HTTLPR polymorphism impacts the functional coupling of the amygdala and the anterior cingulate. Furthermore, this study demonstrates that the degree of functional coupling of the amygdala and the anterior cingulate is a predictor of temperamental anxiety.
20. Blier P. The pharmacology of putative early-onset antidepressant strategies. Eur Neuropsychopharmacol 13 (2003) 57-66
21. Kinney G.G., Vogel G.W., and Feng P. Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression. Brain Res 756 (1997) 68-75
22. Lemonde S., Du L., Bakish D., Hrdina P., and Albert P.R. Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. Int J Neuropsychopharmacol 7 (2004) 501-506
23. Strobel A., Gutknecht L., Rothe C., Reif A., Mossner R., Zeng Y., Brocke B., and Lesch K.P. Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm 110 (2003) 1445-1453
24. 1A promoter polymorphism. This study demonstrates differential effects of the polymorphism on pre- versus post-synaptic htr1a transcription and how these effects are mediated.
25. Parks C.L., Robinson P.S., Sibille E., Shenk T., and Toth M. Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci USA 95 (1998) 10734-10739
26. Ramboz S., Oosting R., Amara D.A., Kung H.F., Blier P., Mendelsohn M., Mann J.J., Brunner D., and Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci USA 95 (1998) 14476-14481
27. Gross C., Zhuang X., Stark K., Ramboz S., Oosting R., Kirby L., Santarelli L., Beck S., and Hen R. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416 (2002) 396-400
28. Zhang X., Gainetdinov R.R., Beaulieu J.M., Sotnikova T.D., Burch L.H., Williams R.B., Schwartz D.A., Krishnan K.R., and Caron M.G. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45 (2005) 11-16. This study identified the human G(1463)A TPH2 polymorphism, which leads to a coding missense loss-of-function mutation, and found an association with unipolar major depression. Subsequent studies demonstrated that this mutation has a very low frequency.
29. Zill P., Baghai T.C., Zwanzger P., Schule C., Eser D., Rupprecht R., Moller H.J., Bondy B., and Ackenheil M. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry 9 (2004) 1030-1036
30. Gizatullin R., Zaboli G., Jonsson E.G., Asberg M., and Leopardi R. Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Biol Psychiatry 59 (2006) 295-300
31. Zhang X., Beaulieu J.M., Sotnikova T.D., Gainetdinov R.R., and Caron M.G. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305 (2004) 217
32. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., and Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
33. Nakamura K., Sugawara Y., Sawabe K., Ohashi A., Tsurui H., Xiu Y., Ohtsuji M., Lin Q.S., Nishimura H., Hasegawa H., et al. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci 26 (2006) 530-534
34. Nakamura K., Koyama Y., Takahashi K., Tsurui H., Xiu Y., Ohtsuji M., Lin Q.S., Sugawara Y., Sawabe K., Ohashi A., et al. Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating. J Mol Biol 363 (2006) 345-354. This study investigates the role of TPH activity during development in modulating sensorimotor gating, deficits of which are seen in schizophrenia, obsessive compulsive disorder, panic disorder, and bipolar disorder.
35. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23 (2000) 477-501
36. Pariante C.M. Depression, stress and the adrenal axis. J Neuroendocrinol 15 (2003) 811-812
37. Chapman D.P., Whitfield C.L., Felitti V.J., Dube S.R., Edwards V.J., and Anda R.F. Adverse childhood experiences and the risk of depressive disorders in adulthood. J Affect Disord 82 (2004) 217-225
38. McCauley J., Kern D.E., Kolodner K., Dill L., Schroeder A.F., DeChant H.K., Ryden J., Derogatis L.R., and Bass E.B. Clinical characteristics of women with a history of childhood abuse: unhealed wounds. JAMA 277 (1997) 1362-1368
39. Heim C., Newport D.J., Wagner D., Wilcox M.M., Miller A.H., and Nemeroff C.B. The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety 15 (2002) 117-125
40. Gorman J.M., Mathew S., and Coplan J. Neurobiology of early life stress: nonhuman primate models. Semin Clin Neuropsychiatry 7 (2002) 96-103
41. Francis D.D., and Meaney M.J. Maternal care and the development of stress responses. Curr Opin Neurobiol 9 (1999) 128-134
42. Caldji C., Diorio J., and Meaney M.J. Variations in maternal care in infancy regulate the development of stress reactivity. Biol Psychiatry 48 (2000) 1164-1174
43. Meaney M.J. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci 24 (2001) 1161-1192
44. Ladd C.O., Owens M.J., and Nemeroff C.B. Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation. Endocrinology 137 (1996) 1212-1218
45. Maciag C.M., Dent G., Gilligan P., He L., Dowling K., Ko T., Levine S., and Smith M.A. Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation. Neuropsychopharmacology 26 (2002) 574-582
46. Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H., Chen R., Marchuk Y., Hauser C., Bentley C.A., et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20 (1998) 1093-1102
47. Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M., Stalla G.K., Blanquet V., Steckler T., Holsboer F., and Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 19 (1998) 162-166
48. Muller M.B., Zimmermann S., Sillaber I., Hagemeyer T.P., Deussing J.M., Timpl P., Kormann M.S., Droste S.K., Kuhn R., Reul J.M., et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 6 (2003) 1100-1107
49. Ladd C.O., Huot R.L., Thrivikraman K.V., Nemeroff C.B., and Plotsky P.M. Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biol Psychiatry 55 (2004) 367-375
50. Vazquez D.M., Van Oers H., Levine S., and Akil H. Regulation of glucocorticoid and mineralocorticoid receptor mRNAs in the hippocampus of the maternally deprived infant rat. Brain Res 731 (1996) 79-90
51. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., and Meaney M.J. Epigenetic programming by maternal behavior. Nat Neurosci 7 (2004) 847-854
52. Champagne F.A., Weaver I.C., Diorio J., Dymov S., Szyf M., and Meaney M.J. Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring. Endocrinology 147 (2006) 2909-2915
53. Champagne F.A., Weaver I.C., Diorio J., Sharma S., and Meaney M.J. Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area. Endocrinology 144 (2003) 4720-4724
54. Duman R.S., and Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59 (2006) 1116-1127
55. Turner C.A., Akil H., Watson S.J., and Evans S.J. The fibroblast growth factor system and mood disorders. Biol Psychiatry 59 (2006) 1128-1135
56. Liu Q.R., Lu L., Zhu X.G., Gong J.P., Shaham Y., and Uhl G.R. Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res 1067 (2006) 1-12
57. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., Zaitsev E., Gold B., Goldman D., Dean M., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
58. Schule C., Zill P., Baghai T.C., Eser D., Zwanzger P., Wenig N., Rupprecht R., and Bondy B. Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology 31 (2006) 1019-1025
59. Chen Z.Y., Jing D., Bath K.G., Ieraci A., Khan T., Siao C.J., Herrera D.G., Toth M., Yang C., McEwen B.S., et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314 (2006) 140-143. A study using genetically modified mice to investigate the role of a common human bdnf polymorphism in depression and anxiety. The first study to demonstrate neuroanatomical and behavioral consequences of the (Val66Met) BDNF mutation in mice.
60. Liu I.Y., Lyons W.E., Mamounas L.A., and Thompson R.F. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. J Neurosci 24 (2004) 7958-7963
61. •].
62. •].
63. Chan J.P., Unger T.J., Byrnes J., and Rios M. Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice. Neuroscience 142 (2006) 49-58. These three studies apply state-of-the-art technology to conditionally manipulate bdnf expression in mice and use this approach to address questions about the tissue specific role of BDNF signaling in emotional behavior. The studies demonstrate that BDNF signaling differentially affects depression-like behavior, depending upon the brain are in which signaling is modulated
64. Videbech P., and Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 161 (2004) 1957-1966
65. MacQueen G.M., Campbell S., McEwen B.S., Macdonald K., Amano S., Joffe R.T., Nahmias C., and Young L.T. Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci USA 100 (2003) 1387-1392
66. Kjelstrup K.G., Tuvnes F.A., Steffenach H.A., Murison R., Moser E.I., and Moser M.B. Reduced fear expression after lesions of the ventral hippocampus. Proc Natl Acad Sci USA 99 (2002) 10825-10830
67. McEwen B.S. Plasticity of the hippocampus: adaptation to chronic stress and allostatic load. Ann N Y Acad Sci 933 (2001) 265-277
68. Dranovsky A., and Hen R. Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry 59 (2006) 1136-1143
69. Duman R.S. Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism. Neurobiol Aging 26 Suppl 1 (2005) 88-93
70. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301 (2003) 805-809
71. Sairanen M., Lucas G., Ernfors P., Castren M., and Castren E. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci 25 (2005) 1089-1094
72. Bredy T.W., Grant R.J., Champagne D.L., and Meaney M.J. Maternal care influences neuronal survival in the hippocampus of the rat. Eur J Neurosci 18 (2003) 2903-2909
73. Mirescu C., Peters J.D., and Gould E. Early life experience alters response of adult neurogenesis to stress. Nat Neurosci 7 (2004) 841-846